Symptoms and General Pathology

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Cushing Syndrome

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Cushing's Syndrome

ACTH-secreting Pituitary Adenoma

Hyperadrenalism

Vasoconstrictor Agents

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All Drugs and Chemicals

Cocaine

Cushing's QoL is a validated disease specific questionnaire consisting of 12 questions on a five-point Likert scale ranging from always to never. The total score ranges from 12 to 60, with a lower score indicating a greater negative impact on health related QoL. This is converted to a 0-100 scale, 0 indicating the worst and 100 indicating the best QoL

Cushing's QoL (Quality of Life Questionnaire)

NHP is used in patients to assess general health and quality of life. This assessment consists of 38 yes/no questions that are subdivided into six scales assessing impairments: pain (eight items), energy level (three items), sleep (five items), emotional reactions (nine items), social isolation (five items) and physical mobility (eight items). A higher score indicates more impairment

Nottingham Health Profile (NHP)

HADS consists of 14 items pertaining to anxiety and depression, with each item measured on a four-point scale. Total scores for the anxiety and depression subscales range from 0 to 21. A higher score indicates greater symptomatology

Hospital Anxiety and Depression Scale (HADS)

The PSS predicts both objective biological markers of stress and increased risk of disease in patients with higher stress levels.

Perceived Stress Scale (PSS)

BDI and BIS in combination have demonstrated that depression and/or binge eating may be mediating factors for the outcome of obesity

Barratt's Impulsivity Scale (BIS)

Beck Depression Inventory (BDI)

The STAI provides data to help distinguish between anxiety and depression.

State-Trait Anxiety Inventory (STAI)

The FCQ-S consists of 15 items assessing: desire to eat, anticipation of positive reinforcement from eating, anticipation of negative reinforcement (reduction of negative affect) from eating, lack of control over eating, and (physiological) hunger; higher scores reflect stronger food craving. Participants respond, using a Likert-type scale, how much each item is true of them right now.

State Food Craving Questionnaire-State (FCQ-S)

Trait food craving will be assessed with the Food Craving Questionnaire-Trait (FCQ-T). The FCQ-T consists of 39 items assessing: intentions/plans to eat, anticipation of positive reinforcement from eating, anticipation of negative reinforcement from eating, lack of control over eating, preoccupation with food, (physiological) hunger, emotions preceding or following food cravings or eating, environmental cues that may elicit food cravings, negative emotions including guilt experienced as a consequence of food cravings, and/or indulging such cravings; higher scores again indicate higher trait craving. Individuals are asked to respond, using a Likert-type scale, how much each item is true of them in general.

Trait Food Craving Questionnaire-Trait (FCQ-T)

A validated visual analogue scale (VAS) questionnaire will be completed in the fasting state. The VAS consists of 100-mm lines with words anchored at each end describing extreme sensations of hunger, prospective consumption ("How much do you think you can eat?"), fullness, and satisfaction, as well as craving (sweet, salty, fatty or savory). Patients will be asked to make a vertical mark across the line corresponding to their feelings. Quantification will performed by measuring the distance from the left end of the line to the mark.

Visual Analogue Scale (VAS)

A validated questionnaire that assesses perceived subjective value attributed to expected/hypothetical foods and other primary reinforcers will be administered. This variant of this questionnaire was initially developed by Dr. Goldstein to assess 'liking' and 'wanting' of expected drug rewards for patients with cocaine addiction. The current assessment uses a modified version to assess 'liking' and 'wanting' for food.

Sensitivity to Reinforcement of Addictive and other Primary Rewards (STRAP-R) food variant

Eliza Geer, MD

Marc Cohen, MD

The purpose of this study is to follow participants with Cushing's syndrome during the course of their routine care and to form a data registry to study long term participant outcomes.

Collecting Information About Treatment Results for Patients With Cushing's Syndrome

Treatment Outcomes for Patients With Cushing's Syndrome: a Prospective Data Collection Study

Memorial Sloan Kettering Cancer Center

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Collecting Information About Treatment Results for Patients With Cushing's Syndrome	NCT03364803	Cushing's Disea... Cushing Syndrom... Cushing Disease	Cushing's QoL (... Nottingham Heal... Hospital Anxiet... Perceived Stres... Barratt's Impul... Beck Depression... State-Trait Anx... State Food Crav... Trait Food Crav... Visual Analogue... Sensitivity to ...	14 Years -	Memorial Sloan Kettering Cancer Center
Collecting Information About Treatment Results for Patients With Cushing's Syndrome	NCT03364803	Cushing's Disea... Cushing Syndrom... Cushing Disease	Cushing's QoL (... Nottingham Heal... Hospital Anxiet... Perceived Stres... Barratt's Impul... Beck Depression... State-Trait Anx... State Food Crav... Trait Food Crav... Visual Analogue... Sensitivity to ...	14 Years -	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for visual analogue scale (vas)