Neoplasms

Nervous System Diseases

All Conditions

Nutritional and Metabolic Diseases

Symptoms and General Pathology

Brain Neoplasms

Hyperlactatemia

Central Nervous System Neoplasms

Nervous System Neoplasms

Brain Diseases

Central Nervous System Diseases

Metabolic Diseases

Central Nervous System Depressants

All Drugs and Chemicals

Anesthetics

Fatma Özkan Sipahioglu

The investigators aimed to research the incidence of hyperlactatemia in craniotomy cases, the relationship of lactate elevation with tumor type and other factors that may be related, and whether the general anesthesia method applied (inhalation anesthesia or total ıntravenous anesthesia) affects lactate level.

Lactate level is one of the easy-to-measure parameters that are frequently used in anesthesia and intensive care clinical practice, especially to evaluate the severity of disease and the response to treatment. In patients with high lactate levels, the first considerations are hypoperfusion and sepsis. However, many causes such as trauma, seizures, ischemia, diabetic ketoacidosis, thiamine deficiency, malignancies, liver dysfunction, genetic disorders, toxins, drugs, etc. can be associated with increased lactate. Many tissues in the body can produce lactate. 25% of production is from muscle, 25% skin, 20% brain, 20% RBC and 10% bowel cells. Some malignancies, especially hematological cancers, have also been associated with increased lactate. In recent years, it has been reported that serum lactate levels are associated with the degree of glial tumor malignancy, and that lactate can even be used as a non-invasive malignancy biomarker in brain tumors. In a recent study, it was reported that the type of 'glioblastoma multiforme' among patients who underwent craniotomy with the diagnosis of intracranial brain tumor was an independent influencer factor for preoperative and postoperative hyperlactatemia. Anesthesia is one of the factors that can affect lactate levels due to its effect on systemic perfusion and the hepatic effects of anesthetic drugs. It looks like that there is no study in the literature on the effect of anesthesia technique on hyperlactatemia in patients who underwent craniotomy. Therefore the investigators aimed to research the incidence of hyperlactatemia in craniotomy cases, the relationship of lactate elevation with tumor type and other factors that may be related, and whether the general anesthesia method applied (inhalation anesthesia or total ıntravenous anesthesia) affects lactate level.

The Relationship of Anesthesia Method With Serum Lactate Level in Craniotomies

basal lactate level via arterial blood gas at the beginning of surgery

lactate level via arterial blood gas at one hour after the beginning of surgery

lactate level via arterial blood gas at three hour after the beginning of surgery

lactate level via arterial blood gas at the end of the surgery

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
The Relationship of Anesthesia Method With Serum Lactate Level in Craniotomies	NCT05145049	Intracranial Ne... Hyperlactatemia Brain Tumor Hypoperfusion		18 Years -	Ankara Diskapi Training and Research Hospital
The Relationship of Anesthesia Method With Serum Lactate Level in Craniotomies	NCT05145049	Intracranial Ne... Hyperlactatemia Brain Tumor Hypoperfusion		18 Years -	Ankara Diskapi Training and Research Hospital

Spots Global Cancer Trial Database for hyperlactatemia