Symptoms and General Pathology

All Conditions

Diseases and Abnormalities at or Before Birth

Nervous System Diseases

Heart and Blood Diseases

Neoplasms

Blood and Lymph Conditions

Rare Diseases

Hemorrhage

Congenital Abnormalities

Cerebral Hemorrhage

Hemangioma, Cavernous, Central Nervous System

Hemangioma

Hemangioma, Cavernous

Intracranial Hemorrhages

Cerebrovascular Disorders

Brain Diseases

Central Nervous System Diseases

Vascular Diseases

Neoplasms, Vascular Tissue

Neoplasms by Histologic Type

Syndrome

Vascular Malformations

Central Nervous System Vascular Malformations

Nervous System Malformations

Cardiovascular Abnormalities

Hemostatic Disorders

Blood Coagulation Disorders

Hemorrhagic Disorders

Hematologic Diseases

Familial Cerebral Cavernous Malformation

Patients with newly diagnosed, cerebral cavernous malformation who will visit one of the study centers during the period from June 2016 to December 2017. Patients would be eligible for enrollment if they were 18 years of age or older and had at least 1 cavernous malformation. All patients who would visit a study center during the enrollment period and meet these criteria will be asked to join the study. The cohort will consists of patients who agree to participate. Target population of this study is 228 patients.

JeongEun Kim, MD. PhD.

The aim of this prospective study is to reveal the natural history of symptomatic hemorrhage in adult patients with cerebral cavernous malformation with the goal of informing the treatment plan.

Cerebral cavernous malformation Patients with newly diagnosed, cerebral cavernous malformation who will visit one of the study centers during the period from June 2016 to December 2017. Patients would be eligible for enrollment if they were 18 years of age or older and had at least 1 cerebral cavernous malformation. If the patient had multiple cavernous malformations, index cavernous malformation would be enrolled. Index lesion will be determined according to the criteria.

* Index lesion decision criteria I. Symptomatic II. Asymptomatic (priorities are as follows)

  1. Previous bleed
  2. Brain stem location
  3. Deep nuclei (thalamus, caudate, basal ggl, hypothalamus)
  4. Periventricular
  5. Largest

All patients who would visit a study center during the enrollment period and meet these criteria will be asked to join the study. The cohort will consists of patients who agree to participate. Target population of this study is 228 patients.

CoHOrt of Cerebral CavernOus maLformATion: multicEnter Prospective Observational Study

A Prospective Study for the Natural History and the Risk Factors of Prospective Symptomatic Hemorrhage in Adult Patients With Cerebral Cavernous Malformation

hemorrhage due to rupture of cavernous malformation

Asan Medical Center

KangWon National University Hospital

Jeju National University Hospital

Chuncheon Sacred Heart Hospital

SMG-SNU Boramae Medical Center

Gyeongsang National University Hospital

Soonchunhyang University Hospital

Johannes Gutenberg University Mainz

First Affiliated Hospital of Suzhou Medical College

Seoul National University Hospital

Professor

Wounds and Injuries

Subarachnoid Hemorrhage

Brain Neoplasms

Stroke

Ischemic Stroke

Ischemia

Hydrocephalus

Craniocerebral Trauma

Trauma, Nervous System

Neurocritical patients including those sustaining head injury, cerebrovascular events (such as intracerebral hemorrhage, subarachnoid hemorrhage, etc.), brain tumor, or hydrocephalus.

Yi-Hsin Tsai, M.D.

The purpose of this study is to use transcranial Doppler (TCD) to predict intracranial pressure (ICP) and clinical outcome of neurocritical patients.

Transcranial Doppler (TCD) and Transcranial color-coded duplex sonography (TCCS) play an important part in neurocritical monitoring systems. Currently there are studies using flow velocities and pulsatility index (PI) to predict intracranial pressure (ICP) and clinical outcome. But the use of B-mode in such prediction is not yet investigated. The purposes of this study are to establish the correlation among clinical data, CT findings and information collected by TCCS, and to predict ICP and neurological outcome using such information. The focus would be on 3rd ventricle size, midline shift and anteroposterior-transverse ration of midbrain (midbrain index) obtained by B-mode of TCCS. This study is a prospective clinical study targeting on 30 neurocritical patients admitted to intensive care units in one year. The timing of performance of TCCS will be (1) within 6 hours after admission, (2) within 6 hours after each CT examination, and (3) when ICP is higher than 20 mmHg for more than 5 minutes. Glasgow coma scale (GCS), heart rate, blood pressure (systolic, diastolic, and mean), body temperature, central venous pressure (CVP), brain temperature, ICP, cerebral perfusion pressure (CPP), mean velocity (MV) of bilateral middle cerebral arteries (MCAs), PI, midline shift, 3rd ventricular dimension, anteroposterior to transverse ratio of midbrain (midbrain index, MI) are recorded. The latter three parameters are also obtained from CT scans, and compared with those obtained from TCCS. Outcome is evaluated with extended Glasgow outcome scale (GOSE), and analyzed with previous records. This study is going to prove that TCCS is a safe, convenient, real-time and cheap tool in clinical care for neurocritical patients. It also provides prediction of ICP and clinical outcome.

The Prediction of Intracranial Pressure and Clinical Outcome by Transcranial Doppler in Neurocritical Patients

National Science Council, Taiwan

National Taiwan University Hospital

Tsai, Yi-Hsin

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
CoHOrt of Cerebral CavernOus maLformATion: multicEnter Prospective Observational Study	NCT02946866	Cerebral Cavern... Intracerebral H...		18 Years - 80 Years	Seoul National University Hospital
The Prediction of Intracranial Pressure and Clinical Outcome by Transcranial Doppler in Neurocritical Patients	NCT00886054	Head Injury Intracerebral H... Ischemic Stroke Subarachnoid He... Brain Tumor Hydrocephalus		16 Years - 80 Years	National Taiwan University Hospital

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