Adjuvants, Anesthesia

Central Nervous System Depressants

Psychotropic Drugs

All Drugs and Chemicals

Anti-Infective Agents

Anti-Arrhythmia Agents

Cardiotonic Agents

Lipid Regulating Agents

Analgesics

Antitussive Agents

Respiratory System Agents

Bone Density Conservation Agents

Anti-Obesity Agents

Vasoconstrictor Agents

Midazolam

Itraconazole

Digoxin

Rosuvastatin Calcium

Levomethorphan

Dextromethorphan

Rifampin

Hydroxyitraconazole

Calcium

Calcium, Dietary

Anesthetics

Hypnotics and Sedatives

Anti-Anxiety Agents

Anesthetics, Intravenous

Anesthetics, General

GABA Modulators

Neurotransmitter Agents

Anticholesteremic Agents

Hypolipidemic Agents

Antimetabolites

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Enzyme Inhibitors

Clotrimazole

Miconazole

Antifungal Agents

Cytochrome P-450 Enzyme Inhibitors

Hormones

Hormone Antagonists

Cytochrome P-450 CYP3A Inhibitors

Anti-Bacterial Agents

Antibiotics, Antitubercular

Antitubercular Agents

Protective Agents

Phenylpropanolamine

Guaifenesin

Chlorpheniramine, phenylpropanolamine drug combination

Excitatory Amino Acid Antagonists

Analgesics, Opioid

Narcotics

Enrolled subjects were treated with JMKX001899 on Day 1. Itraconazole was administered orally once daily after a standardized meal from Day 4 to Day 6. JMKX001899 and itraconazole were administered simultaneously after a standardized meal on Day 7. On Day 8 to Day 9, itraconazole was orally administered once after a standard meal

Enrolled subjects were treated with JMKX001899 after high fat meal on Day 1 and an empty stomach on Day 4. Rifampin was administered orally once daily on an empty stomac from Day 7 to Day 15, Day 17and Day 18. JMKX001899 and Rigampin were administered simultaneously on an empty stomach on Day 16.

Enrolled subjects were treated with Cocktail substrate (Midazolam, dextromethorphan, Rosuvastatin and digoxin) on an empty stomach on Day 1. JMKX001899 was administered orally once daily after a standardized meal from Day 9 to Day 20 and Day 22. Cocktail and JMKX001899 were administered simultaneously on an empty stomach on Day 8 and Day 21.

JMKX001899

dextromethorphan

Rosuvastatin

digoxin

JING XU

This is an open-label, non-randomized, clinical study to evaluate the drug interaction between itraconazole, rifampin or Cocktail and JMKX001899 in healthy subjects. A total of three cohorts of 72 healthy subjects were planned to be enrolled in each cohort.

Study to Evaluate the Drug-drug Interaction of JMKX001899 in Healthy Subjects

a Single-center, Non-randomized, Open-label, Self-controlled Phase 1 Clinical Study to Evaluate Drug-drug Interactions of JMKX001899 Tablets in Healthy Subjects

Jemincare

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Study to Evaluate the Drug-drug Interaction of JMKX001899 in Healthy Subjects	NCT06348290	Solid Tumor, Ad...	JMKX001899 Itraconazole Midazolam Rifampin dextromethorpha... Rosuvastatin digoxin	18 Years - 45 Years	Jemincare
Study to Evaluate the Drug-drug Interaction of JMKX001899 in Healthy Subjects	NCT06348290	Solid Tumor, Ad...	JMKX001899 Itraconazole Midazolam Rifampin dextromethorpha... Rosuvastatin digoxin	18 Years - 45 Years	Jemincare

Spots Global Cancer Trial Database for jmkx001899

Every month we try and update this database with for jmkx001899 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for jmkx001899

Every month we try and update this database with for jmkx001899 cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for jmkx001899 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.