Neoplasms

Digestive System Diseases

All Conditions

Rectal Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Intestinal Diseases

Rectal Diseases

Loop protective ileostomy as a defunction mean after low anterior resection with D3 lymphnode dissection

Loop protective transverse colostomy as a defunction mean after low anterior resection with D3 lymphnode dissection

Nerve-sparing paraaortic lymph node dissection is performed. The inferior mesenteric artery is divided at 1-2 cm from its origin from the aorta or right below left colic artery. Nerve-sparing total mesorectal excision is performed. Side-to-end sigmoido-rectal anastomosis is created. A loop defunctioning ileostomy is performed.

Low anterior resection with protective loop ileostomy

Nerve-sparing paraaortic lymph node dissection is performed. The inferior mesenteric artery is divided at 1-2 cm from its origin from the aorta or right below left colic artery. Nerve-sparing total mesorectal excision is performed. Side-to-end sigmoido-rectal anastomosis is created. A loop defunctioning transverse colostomy is performed.

Low anterior resection with protective loop transverse colostomy

Petr Tsarkov

Inna Tulina

The type of preventive intestinal stoma (colostomy/ileostomy) after low anterior rectal resection rectum is still a debate.

This study purpose is to demonstrate that preventive loop ileostomy is characterized by a higher readmission rate caused by dehydration, in comparison with the loop colostomy.

Modern surgery for the rectal cancer is featured by sphincter-preserving operations. It is proved that colorectal anastomosis leakage is severe and, in some cases, lethal complication that reduces quality of life of patients and increases the risk of disease reccurence.

The presence of preventive stoma is an effective way to avoid this complication that is why it's included to treatment protocols for the middle and low ampullary rectal cancers is undisputed by the most of surgeons. However, the type of preventive stoma is under discussion yet and remains to be an urgent issue.

The majority of large meta-analyzes demonstrates that preventive ileostomy is used more often for the protection of low colorectal anastomoses. In the western countries the preferred method is double barreled ileostomy due to more rapid formation and closure, as well as due to lower rate of stoma-related morbidity.

In Russia and CIS countries the double-barreled transverse colostomy is a preferred method of defuction of low colorectal anastomosis due to lower rate of electrolytic disorders and related hospital admissions, along with series of unproven advantages.

Presented study will allow to reveal the early and late postoperative morbidity rate and the related hospital re-admissions in real-life clinical practice of Russia from the standpoints of evidence- based medicine, to define indications and contraindications for each type of "low" colorectal anastomosis protection with the least risk for the patient.

PReventive cOlostomy vs Ileostomy in Low anTErior reCTal Resection

Multi-center, Randomized, Parallel-group, Superiority Study to Compare Outcomes of Protective Double-Barrelled Colostomy Versus Protective Double-Barrelled Ileostomy in Low Anterior Resection for Rectal Cancer

The percentage of patients who were readmitted to the hospital due to dehydration, that could not be managed in outhospital setting

The rate of all postoperative complications in early postoperative period after resectional surgery

The rate of all postoperative complications

Assessed with patient-reported questionnaire SF-36. A total score in each of 8 sections will be calculated and transformed into a 0-100 scale with a score of zero equivalent to maximum disability and a score of 100 equivalent to no disability

The period of time between initial resectional procedure and closure of protetctive stoma only in patients who had their intestinal stoma reversed

The rate of early postoperative complications after stoma closure operation

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
PReventive cOlostomy vs Ileostomy in Low anTErior reCTal Resection	NCT04357171	Rectal Cancer	Low anterior re... Low anterior re...	18 Years - 85 Years	Russian Society of Colorectal Surgeons
PReventive cOlostomy vs Ileostomy in Low anTErior reCTal Resection	NCT04357171	Rectal Cancer	Low anterior re... Low anterior re...	18 Years - 85 Years	Russian Society of Colorectal Surgeons

Spots Global Cancer Trial Database for low anterior resection with protective loop ileostomy