Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Blood and Lymph Conditions

Immune System Diseases

Skin and Connective Tissue Diseases

Rare Diseases

Lung Neoplasms

Lymphoma

Melanoma

Head and Neck Neoplasms

Lymphosarcoma

After undergoing standard PET/CT, patients undergo PET/MRI.

University Hospitals Seidman Cancer Center \[SCC\] will house the Philips Ingenuity TF PET/MR, which is a hybrid scanner that merges magnetic resonance imaging with positron emission tomography scanning. University Hospitals is one of only five hospitals in the world with this technology. The PET/MRI system consists of two imaging scanners used sequentially as in PET/CT. The 3Tesla MRI component provides the high resolution that is necessary for soft tissue contrast and functional information on perfusion, diffusion, or metabolism. PET provides information about cellular metabolism and receptor status.

magnetic resonance imaging with positron emission tomography scanning

Peter Faulhaber

This clinical trial studies positron emission tomography (PET)/magnetic resonance imaging (MRI) in patients undergoing PET/computed tomography (CT). Diagnostic procedures, such as PET/MRI, may help doctors diagnose cancer or help doctors predict a patient's response to treatment

PRIMARY OBJECTIVES:

I. To acquire PET/MRI scans of 100 patients which will be compared with PET/CT scans of the same subjects. The PET/CT scans will be used to provide the gold standard for evaluating the image quality and quantitative performance of the PET/MRI scans. After comparison and evaluation of the imaging capabilities and performance of the sequential PET/MRI imaging system for these 100 subjects, a second cohort of hundred consecutive subjects may be necessary and again comparisons made to the current standard of PET imaging, PET/CT. This validation of the attenuation correction methods and quantitative accuracy of the PET/MRI device compared to PET/CT will be a continuous iterative process that will result in optimized performance of the PET/MRI and will be a key step in its becoming available to other clinical research projects both within the Seidman Cancer Center as well as in other institutions.

OUTLINE:

After undergoing standard PET/CT, patients undergo PET/MRI.

Positron Emission Tomography/Magnetic Resonance Imaging in Patients

Evaluating Attenuation Correction Methods Applied to PET/MRI

SUVs for various normal tissues such as liver, cardiac blood pool, and bone will be used. Selected lesions will be assessed as well. Maximum and mean SUVs will be measured for each imaging device. The SUVs and tumor/background ratios will be measured.

A Likert five point scale will be used. Quality scores will be compared using a Wilcoxon signed rank test.

National Cancer Institute (NCI)

Case Comprehensive Cancer Center

No adverse events were documented for this study

After undergoing standard PET/CT, patients undergo PET/MRI.

magnetic resonance imaging with positron emission tomography scanning: University Hospitals Seidman Cancer Center \[SCC\] will house the Philips Ingenuity TF PET/MR, which is a hybrid scanner that merges magnetic resonance imaging with positron emission tomography scanning. University Hospitals is one of only five hospitals in the world with this technology. The PET/MRI system consists of two imaging scanners used sequentially as in PET/CT. The 3Tesla MRI component provides the high resolution that is necessary for soft tissue contrast and functional information on perfusion, diffusion, or metabolism. PET provides information about cellular metabolism and receptor status.

Diagnostic (PET/MRI)

20-29 years

30-39 years

40-49 years

50-59 years

60-69 years

70-79 years

80-89 years

90-99

Age, Customized

Gender

Sex/Gender, Customized

Ethnicity (NIH/OMB)

Race (NIH/OMB)

United States

Region of Enrollment

Philipp Frank Graner

Not available because SUV data not collected.

Standardized Uptake Value (SUV) on PET/CT Compared to PET/MRI

Not available because data not collected.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Positron Emission Tomography/Magnetic Resonance Imaging in Patients	NCT01557881	Colon Cancer Head and Neck C... Lung Cancer Lymphoma Malignant Neopl... Melanoma Unspecified Adu... Unspecified Chi...	magnetic resona...	-	Case Comprehensive Cancer Center
Positron Emission Tomography/Magnetic Resonance Imaging in Patients	NCT01557881	Colon Cancer Head and Neck C... Lung Cancer Lymphoma Malignant Neopl... Melanoma Unspecified Adu... Unspecified Chi...	magnetic resona...	-	Case Comprehensive Cancer Center
Positron Emission Tomography/Magnetic Resonance Imaging in Patients	NCT01557881	Colon Cancer Head and Neck C... Lung Cancer Lymphoma Malignant Neopl... Melanoma Unspecified Adu... Unspecified Chi...	magnetic resona...	-	Case Comprehensive Cancer Center

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