Symptoms and General Pathology

All Conditions

Mouth and Tooth Diseases

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Gland and Hormone Related Diseases

Rare Diseases

Syndrome

Periodontitis

Polycystic Ovary Syndrome

Chronic Periodontitis

Periodontal Diseases

Mouth Diseases

Stomatognathic Diseases

Cysts

Ovarian Cysts

Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Gonadal Disorders

Endocrine System Diseases

Chronic Disease

Disease Attributes

Chronic Graft Versus Host Disease

Oculocerebral Syndrome With Hypopigmentation

All Drugs and Chemicals

Antioxidants

systemically and periodontally healthy participants

systemically healthy participants with CP

PCOS participants with periodontally healthy

no intervention provided

Nesrin Saruhan, PhD

Cenk Fatih Çanakcı, Prof

Saime Ozbek Sebin, Dr

Humeyra Canakcı, Dr

Metin İngeç, Prof

Ufuk Sezer, Phd

Ebru Saglam, PhD

Background: The aim of this study was to investigate the levels of malondialdehyde (MDA), total antioxidant status (TAS), 8-hydroxy-2´- deoxyguanosine (8-OHdG) in blood serum and saliva samples in female patients with chronic periodontitis (CP) and to compared healthy individuals.

Materials and Methods: A total of 88 women were into four groups each which were consisted of twenty-two subjects. Groups were designed as periodontally and systemically healthy women (PCOS-CP-); periodontally healthy women with polycystic ovary syndrome (PCOS) (PCOS+CP-), systemically healthy women with CP (PCOS-,CP+) and women with PCOS and CP (PCOS+CP+). Serum and salivary samples were obtained, clinical periodontal parameters were recorded. MDA, TAS, 8-OHdG levels were measured as biochemically.

RESULTS:

Salivary 8-OHdG levels in the PCOSCP and CP groups were statistically higher than those in both the PCOSPH and the PH groups (P \< 0.05). There was no statistical difference between the PCOSCP, CP, and PCOSPH groups with regard to salivary MDA and TAS levels (P \> 0.05). Highest serum 8-OHdG and MDA levels and lowest serum TAS levels were seen in the PCOSCP group (P \< 0.05). Serum 8-OHdG and MDA levels in the PCOSPH group were higher than those in both systemically healthy groups (PH and CP) (P \< 0.05). Salivary TAS levels were highest (P \< 0.05) in the PH group. There was no statistical difference between the CP and PCOSPH groups, but serum TAS levels were lower than those in the PH group (P \< 0.05).

CONCLUSIONS:

CP, which led to an increase in serum and salivary 8-OHdG and MDA levels and a decrease in serum TAS levels in patients with PCOS, contributed to increased OS. This effect was more prominent in serum levels than in salivary levels.

Serum and saliva samples were obtained and stored until biochemical analyses

Chronic Periodontitis and Polycystic Ovary Syndrome

Evaluation Of Lipid Peroxidation, Oxidative DNA Damage And Total Antioxidant Status In Patients With Periodontitis And Polycystic Ovary Syndrome: A Cross Sectional Study

by measuring the distance between the cementoenamel junction and the periodontal pocket base

distance between free gingival margin and periodontal pocket base by usin periodontal probe

Bezmialem Vakif University

Skin and Connective Tissue Diseases

Keratosis, Actinic

Keratosis

Lichen Planus, Oral

Lichen Planus

Mouth Neoplasms

Leukoplakia

Leukoplakia, Oral

Skin Diseases

Precancerous Conditions

Lichenoid Eruptions

Exanthema

Skin Diseases, Papulosquamous

Head and Neck Neoplasms

Pathological Conditions, Anatomical

Oral Cancer

Lip and Oral Cavity Cancer

Oral Leukoplakia

Analgesics

Central Nervous System Depressants

Vasodilator Agents

Respiratory System Agents

Nitrous Oxide

Nitric Oxide

salivary biomarker

weam Elbattawy, Phd

investigating the level of malondialdehyde (MDA) \& nitric oxide (NO) in saliva in oral premalignant and malignant lesions in order to determine their diagnostic value for the malignant and potentially malignant lesions.

Being a detrimental disease, cancer development is a very complicated process that requires many sequential steps and depends on a various number of genetic alterations and factors(1). Among these factors are the free radicals which are derived either from endogenous or exogenous sources (5). Free radicals result in an oxidative stress of the affected cells generating a body imbalance between oxidants and antioxidants (6).

In this regard, saliva has been currently used to assess this possible oxidative imbalance through various salivary biomarkers including nitric oxide (NO) and malondialdehyde (MDA). Saliva could be used as a very interesting rich medium, known for its role in diagnosis, prognosis and treatment that has become more prominent in oral diseases (6).

Nitric oxide (NO) is an intercellular messenger molecule having many important biological functions. The levels of nitric oxide in salivary secretions could be used to monitor the severity of many underlying disease processes. Moreover, malondialdehyde (MDA) has been the most frequently used biomarker of oxidative stress in many pathological conditions such as cancer. It resulted from reactive oxygen species lipid degradation and induced toxic stress in affected cells, making both biomarkers a point of focus in monitoring clinical progress of suspected lesions

Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions

all the data will shared once the work is published

The MDA level in saliva measured using ELISA kit provided by My BioSource, USA.

The nitric oxide level in saliva measured using ELISA kit provided by My BioSource, USA.

Beni-Suef University

principle investigator

Digestive System Diseases

Respiratory Tract (Lung and Bronchial) Diseases

Diseases and Abnormalities at or Before Birth

Inflammation

Alpha 1-Antitrypsin Deficiency

Alpha-1 Antitrypsin Deficiency

Micronutrients

Reproductive Control Agents

Antineoplastic Agents

Vitamins

Fluorodeoxyglucose F18

Tocopherols

Vitamin E

Tocotrienols

alpha-Tocopherol

Dinoprost

Dinoprost tromethamine

Vitamin A

Retinol palmitate

Catalase

Alpha 1-Antitrypsin

Protein C Inhibitor

Tocopherol

Tocotrienol

Retinol

Oncological patients: lymphomas (Hodgkin's, DLBCL), breast and ovarian cancers, brain gliomas.

The number at most half as large as the patients' group, composed of healthy people at similar age and the same sex as patients.

The FDG PET/CT imaging will be performed as part of typical medical procedures related to the diagnosis and monitoring of cancers at the Oncology Center in Bydgoszcz, Poland

Patients

Paweł Sutkowy, PhD

The research aims to determine the parameters of oxidative stress and inflammatory processes and compare these parameters with the image obtained using positron emission tomography (PET) with 2-deoxy-2-\[fluorine-18\]fluoro- D-glucose (18F-FDG) integrated with computed tomography (CT) in the group of oncological patients.

FDG PET/CT is very sensitive imaging tool for the detection of neoplasms. Neoplasm tissue is characterized by a much higher level of metabolism than healthy tissues, therefore a 95% cases of use the method regard oncology. Fluorodeoxyglucose (FDG) is absorbed by patients' organism as glucose but it does not undergo metabolism. The increased degree of FDG accumulation in tissue means its higher metabolic activity. FDG accumulates in the tumor tissue and radiates enabling its detection but the substance has not been shown to be harmful to patient at doses used in the diagnostics.

Tumor formation is a multi-stage process in which the phases of initiation, promotion and progression are distinguished. Neoplastic transformation of healthy cells is associated with disturbances of the cell cycle caused by mutations of proto-oncogenes (activation of cell division) and/or suppressor genes (blocking cell division) and mutator genes (protecting the DNA against damage or its repairing) under the influence of various factors. Increasing data indicate that one of the most important factors initiating neoplasm are reactive oxygen species (ROS) and oxidative stress. Mechanisms responsible for induction of oxidative stress in cancer cells are not fully explained. It is known that they are closely related to inflammation, as well as intense cellular metabolism associated with continuous proliferation, mutations in the genetic material and dysfunctions in the mitochondrial respiratory chain.

In this study a number of markers of oxidative stress and inflammation are planned to be determined including: the activities of antioxidant and lysosomal enzymes, as well as concentrations of lipid peroxidation products and low molecular weight antioxidants. The PET/CT imaging will be performed as part of standard medical procedures related to the diagnosis and monitoring of cancer diseases at the Oncology Center in Bydgoszcz, Poland.

Venous blood collected from the basilic vein from the study participants into two vacuum test tubes only once (from patients during FDG PET-CT diagnosis): for full blood (K2EDTA) and blood serum (clot activator and gel separator).

Oxidoreductive Balance and Lysosomal Activity in Cancer Patients.

Oxidative Stress and Inflammatory Processes in Selected Neoplasms in the Group of Oncological Patients Examined With the FDG PET/CT Method.

There is no the individual participant data (IPD) sharing plan.

Total antioxidant potential of blood serum in the participant

Positron emission tomography with 2-deoxy-2-\[fluorine-18\]fluoro- D-glucose integrated with computed tomography

Nicolaus Copernicus University

Assistant professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Chronic Periodontitis and Polycystic Ovary Syndrome	NCT02954120	Polycystic Ovar... Chronic Periodo...	no intervention...	18 Years - 40 Years	Bezmialem Vakif University
Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions	NCT04267419	Oral Lichen Pla... Oral Cancer Leukoplakia Oral Keratoses	salivary biomar...	18 Years - 70 Years	Beni-Suef University
Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions	NCT04267419	Oral Lichen Pla... Oral Cancer Leukoplakia Oral Keratoses	salivary biomar...	18 Years - 70 Years	Beni-Suef University
Oxidoreductive Balance and Lysosomal Activity in Cancer Patients.	NCT03470857	Neoplasms Antioxidants Oxidative Stres... Lipid Peroxidat... Inflammation Lysosome Altera...	Patients	18 Years -	Nicolaus Copernicus University

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