Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Infections

Symptoms and General Pathology

Rare Diseases

Lung Neoplasms

Carcinoma, Non-Small-Cell Lung

Pleural Effusion

Virus Diseases

Measles

Carcinoma

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Carcinoma, Bronchogenic

Bronchial Neoplasms

Communicable Diseases

Paramyxoviridae Infections

Mononegavirales Infections

RNA Virus Infections

All Drugs and Chemicals

Vaccines

4-week apart, two vaccines starting 4 weeks after last chemotherapy

attenuated measles vaccine

Samuel Ariad, MD

The objectives of the study are to assess the efficacy and safety of live, attenuated measles vaccine as consolidation therapy in patients with measles-positive, non-small cell lung cancer with locally-advanced (stage 3B with pleural effusion) or metastatic (stage 4) tumors in remission.

This is a single-institution, non-randomized phase 1/2 study in patients with locally-advanced or metastatic NSCLC in remission after receiving standard systemic chemotherapy of four cycles of combination chemotherapy consisting of four cycles of cisplatin combined with vinorelbine.

Measles Vaccine in Patients With Measles Virus-Positive, Advanced Non-Small Cell Lung Cancer

A Single-Institution, Open-Label, Single-Arm phase1/2 Study of Measles Vaccine as Consolidation in Patients With Measles Virus-Positive, Stage 3B/4 Non-Small Cell Lung Cancer

Soroka University Medical Center

Prof. Samuel Ariad

Blood and Lymph Conditions

Immune System Diseases

Leukemia

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Leukemia, Lymphoid

Herpes Zoster

Chickenpox

Lymphoma

Neoplasms by Histologic Type

Hematologic Diseases

Lymphoproliferative Disorders

Lymphatic Diseases

Immunoproliferative Disorders

Acute Lymphoblastic Leukemia

Lymphoblastic Lymphoma

Acute Graft Versus Host Disease

Childhood Acute Lymphoblastic Leukemia

Lymphosarcoma

Antibodies

Immunoglobulins

Heptavalent Pneumococcal Conjugate Vaccine

This cohort of participants who recently completed leukemia therapy will be assessed for infection incidence during the year following treatment and give blood samples to be measured for antibodies to vaccine-preventable diseases. A small subset will also have their blood samples tested for B and T cell recovery.

Blood samples will be tested to measure antibodies to vaccine-preventable diseases and immune recovery

Observational only

Brian T Fisher, DO MSCE MPH

This observational study aims to assess recovery of the immune system and immunity to vaccine-preventable diseases in children and adolescents who recently completed treatment for acute lymphoblastic leukemia (ALL). Several children's hospitals in the United States are participating in the study, which will enroll approximately 75 pediatric participants. The study is intended to determine the rate of infection after leukemia treatment and to inform future studies and recommendations about whether children and adolescents who have leukemia should receive additional vaccine doses or boosters after treatment.

Serum, peripheral blood mononuclear cells

Vaccine Immune Recovery After Leukemia

A Prospective Cohort Study to Define Infectious Burden, the Seroprevalence of Vaccine Preventable Pathogens and Immune Recovery in the First Year Following Completion of Therapy in Patients With Acute Lymphoblastic Leukemia (ALL)

Infections will include both clinical and/or microbiologically confirmed infections. All unique infections for a given subject will be captured and included in the final infection rate per person time estimate. Infections will also be reported in subsets of infections such as microbiologically confirmed or clinically defined infections. The total number of unique infections identified within the first year after completing chemotherapy will be reported as a rate per 1000 follow-up days. This rate will be reported for the entire cohort, by study site, and by demographics. This outcome will also be reported within subsets of infection type reported as a rate per 1000 follow-up days for the entire cohort, by study site and by specific demographic variables. All infection rates will be reported as a post estimate with 95 percent confidence intervals. Patients will be censored at time of lost to follow-up or death.

The seroprevalence proportions for measles antibodies will be determined for the entire cohort and by demographics at each study follow-up time point (3, 6, and 12 months). Additionally, seroprevalence at each time point will be described for participants who had and had not completed their primary vaccine series before starting chemotherapy.

The seroprevalence proportions for varicella antibodies will be determined for the entire cohort and by demographics at each study follow-up time point (3, 6, and 12 months). Additionally, seroprevalence at each time point will be described for participants who had and had not completed their primary vaccine series before starting chemotherapy.

The seroprevalence proportions for pneumococcal antibodies (23 serotypes) will be determined for the entire cohort and by demographics at each study follow-up time point (3, 6, and 12 months). Additionally, seroprevalence at each time point will be described for participants who had and had not completed their primary vaccine series before starting chemotherapy.

B lymphocyte subsets will be measured for a subset of the 75 enrolled subjects. These measurements will be reported for each subject at approximately 3, 6, and 12 months. The trajectory of these measurements will be displayed graphically across the three timepoints of interest to assess relative recovery of lymphocyte quantities after completion of ALL chemotherapy.

T lymphocyte subsets will be measured for a subset of the 75 enrolled subjects. These measurements will be reported for each subject at approximately 3, 6, and 12 months. The trajectory of these measurements will be displayed graphically across the three timepoints of interest to assess relative recovery of lymphocyte quantities after completion of ALL chemotherapy.

Merck Sharp & Dohme LLC

Children's Hospital of Philadelphia

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Measles Vaccine in Patients With Measles Virus-Positive, Advanced Non-Small Cell Lung Cancer	NCT00828022	Non-Small Cell ... Measles	attenuated meas...	18 Years - 80 Years	Soroka University Medical Center
Vaccine Immune Recovery After Leukemia	NCT05622682	Acute Lymphobla...	Observational o...	3 Years - 31 Years	Children's Hospital of Philadelphia

Spots Global Cancer Trial Database for measles vaccine