Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Rare Diseases

Melanoma

Neuroendocrine Tumors

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Neoplasms, Nerve Tissue

Nevus, Pigmented

Nevus

Nevi and Melanomas

Skin Neoplasms

Skin Diseases

Neuroendocrine Tumor

Neuroepithelioma

All Drugs and Chemicals

Antineoplastic Agents

Anti-Infective Agents

Antibodies

Immunomodulating Agents

Nivolumab

Atezolizumab

Ipilimumab

Immunoglobulins

Nitrofurazone

Antineoplastic Agents, Immunological

Immune Checkpoint Inhibitors

This cohort will consist of 1000 healthy volunteers from Poland.

This cohort will consist of 160 patients with melanoma.

Patients receiving routine treatment (immunotherapy using anti-PD1 / anti-PDL1 and / or anti CTLA4 antibodies), financed by the Polish National Health Fund (NFZ).

Collection of stool samples

Anna Philips, PhD

Emilia Strycharz-Angrecka

Jan Majta

Knowledge about the correlations between the composition of the gut microbiome and a wide range of diseases has substantially increased in recent years. Nonetheless, there is no reference set of information about the microbiome in Poland. The development of such a reference will allow polish scientists conducting research in the field of interaction between gut flora components and such characteristics as lifestyle, certain diseases or patient's responses for treatment. Following the example of such countries as the United States, investigators propose to build a unique set of scientific processed information describing the variability of the polish population microbiome (Polish Microbiome Map). The investigators will provide a reliable dataset that will characterize the gut microbiomes and their diversity in the polish population. Additionally, thanks to the creation of the standard protocol for microbiome data collection the research conducted by the MMP users will be comparable with the information deposited in MMP.

Polish Microbiome Map

Microbial DNA - stool samples sequenced by next-generation sequencing platform.

It includes questions about healthy volunteers' and patients' eating habits that may relate to their health.

The Institute of Bioorganic Chemistry, Polish Academy of Sciences

National Center for Research and Development, Poland

Ardigen

Respiratory Tract (Lung and Bronchial) Diseases

Carcinoma, Non-Small-Cell Lung

Lung Neoplasms

Carcinoma

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Carcinoma, Bronchogenic

Bronchial Neoplasms

Dermatologic Agents

Coal Tar

This cohort will consist of 100 patients with non-small cell lung cancer (NSCLC).

This cohort will consist of 30 patients with melanoma (MEL).

Collection of stool, blood (PBMC) and biopsy (FFPE)

Martyna Balawejder

Bozena Augustyn

Michal Warchol, PhD

The goal of the project is to develop and validate the BioForte technology. Its main functionality should be to in silico determine candidates for novel microbiome-based therapeutics and diagnostics. Key challenge to be solved using the technology is to detect the differences in gut microbiome between oncology patients who respond to immunotherapies and the ones who do not respond to this treatment.

This technology employs machine learning methods to replace the laboratory procedure for finding valuable genomic features. Such features can be crucial to identify differences between the two populations (e.g. responders vs non-responders) to target specific strains.

The samples and data collected in this clinical study will be used for clinical validation of BioForte technology. For all patients treated with immunotherapy, stool collection will be performed per patient (one stool collection before setting up immunotherapy using anti-PD1 / anti-PDL1 and / or anti CTLA4 antibodies). Samples will be sequenced by long-read sequencing technology. In parallel, we will also collect samples of peripheral blood samples (PBMC) and biopsy (FFPE).

stool, biopsy (FFPE) and peripheral blood samples (PBMC)

BioForte Technology for in Silico Identification of Candidates for a New Microbiome-based Therapeutics and Diagnostics

Development of BioForte Technology for in Silico Identification of Valuable Genomic Features That Are Candidates for Microbiome-based Therapeutics and Diagnostics.

Microbila DNA - stool samples sequenced by long-read sequencing technology.

Standard follow-up care after cancer treatment.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Polish Microbiome Map	NCT04169867	Melanoma Healthy Volunte... Microbiome Metagenome Immunotherapy	Collection of s...	18 Years -	Ardigen
BioForte Technology for in Silico Identification of Candidates for a New Microbiome-based Therapeutics and Diagnostics	NCT04136470	Non Small Cell ... Microbiome Metagenome Immunotherapy Melanoma	Collection of s...	18 Years -	Ardigen
BioForte Technology for in Silico Identification of Candidates for a New Microbiome-based Therapeutics and Diagnostics	NCT04136470	Non Small Cell ... Microbiome Metagenome Immunotherapy Melanoma	Collection of s...	18 Years -	Ardigen

Spots Global Cancer Trial Database for metagenome

Every month we try and update this database with for metagenome cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for metagenome

Every month we try and update this database with for metagenome cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for metagenome cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.