Behaviors and Mental Disorders

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Genital Diseases

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Mineralocorticoids

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Hormone Antagonists

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Contraceptive Agents, Hormonal

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Lifestyle intervention, oral contraceptive pills and metformin will be given to improve the symptoms of PCOS patients, such as obesity, hyperandrogegism, and insulin resistance, and to compare the different psychological status in PCOS.

One of the three medications like ethinylestradiol (35 μg) and cyproterone acetate, drospirenone and ethinylestradiol tablets (I) and (Ⅱ) will be used as an antiandrogen.

Oral Contraceptives, Combined

Metformin is used to lower insulin resistance or to modulate hyperinsulinism.

Metformin Pill

Weight control including calorie restriction and moderate exercise will be recommended to obese PCOS patients

lifestyle intervention

Hexia Xia, Doctor

Wei Zhang, Doctor

Haiyun Guan, Doctor

Rongmin Wang, Master

Zhijing Tang, PhD student

The current study intends to establish a prediction method and evaluation system for polycystic ovary syndrome (PCOS) complicated with affective disorder, such as depression and anxiety, through the epidemiological investigation. Randomized controlled studies on the efficacy of various intervention methods should be carried out to develop early intervention measures and methods in order to reduce the harm of psychological disorders, to facilitate the mental health of PCOS patients, and thus to improve the quality of life.

PCOS is one of the most common reproductive endocrine and metabolic diseases in women of adolescence and childbearing age. The prevalence of PCOS in reproductive women is as high as 5-10%, about 50-80% of whom are infertile and need ovulation induction or in vitro fertilization-embryo transfer (IVF-ET). Ovulation/anovulation and hyperandrogenemia are two main features of PCOS. Moreover, about 50-60% of PCOS patients present insulin resistance/hyperinsulinemia. The probability of miscarriage in PCOS is also higher than that of control women. Pregnancy complications in PCOS patients, such as gestational diabetes, preeclampsia, etc., and long-term complications of metabolic syndrome and endometrial cancer are more likely to happen. These not only greatly affect women's reproductive health, but also seriously endanger their psychological status. A large sample of data has shown that the risk of depression in women with PCOS is 3.78 times higher than that of the control women, 5.62 times for anxiety, and 1.78 times for bipolar disorder. With the economic development, more and more attention is paid to the quality of life including their mental health. However, there is few data on the risk factors of depression, anxiety and other psychological disorders in women with PCOS. There is a lack of effective evaluation and prediction systems. It is urgent to establish a risk assessment system for PCOS complicated with psychological diseases through scientific and systematic research, to formulate comprehensive intervention measures to improve the quality of life of women with PCOS and to reduce the incidence of affective disorders.

Research on Risk Factors and Interventions of Polycystic Ovary Syndrome Complicated With Depression and Anxiety

Research on Risk Factors and Comprehensive Intervention Measures of Polycystic Ovary Syndrome Complicated With Mental Diseases Such as Depression and Anxiety

The self-rating depression scale(SDS) is assessed before and after intervention. The SDS score multiplied by 1.25 is a standard score, which is between 25-100. A score no less than 50 is consider as depression.

The self-rating anxiety scale(SAS) is assessed before and after intervention. The SAS score multiplied by 1.25 is a standard score, which is between 25-100. A score no less than 50 is consider as anxiety.

The scores of Health Related Quality of Life Questionnaire are assessed before and after treatment, which range from 30 to 210. Higher scores indicate higher quality of life of PCOS patients with less influence from PCOS.

Fudan University

professor

Nutritional and Metabolic Diseases

Obesity

laparoscopic sleeve gastrectomy

Shen Qu, Dr

Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with a prevalence of 5% to 15% in premenopausal women. Patients with PCOS presents as abnormal menstruation, ovulation disorders and/or hyperandrogenemia, and often accompanied by insulin resistance and other metabolic abnormalities. Sleeve gastrectomy was an effective threapy for severe obesity patients. This study will evaluate the clinical efficacy of sleeve gastrectomy for obese patients with PCOS. Mealwhile, the specific mechanism of sleeve gastrectomy for improving obese patients with PCOS will be explored through multi-group analysis.

Treating Obese PCOS Patients With LSG vs. Met

Comparison of the Clinical Efficacy of Laparoscopic Sleeve Gastrectomy and Metformin in the Treatment of Obese Patients With Polycystic Ovary Syndrome

The investigators will perform metabolites to identify the changes that may give rise to the disease.

The investigators will perform transcriptome profile to identify the changes that may give rise to the disease.

The investigators will perform Microbiome to identify the changes that may give rise to the disease.

total testosterone (nmol/L), testosterone (nmol/L)

high-density lipoprotein cholesterol (mmol/L)

low-density lipoprotein cholesterol (mmol/L)

Shanghai 10th People's Hospital

Department of Endocrinology & Metabolism

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Research on Risk Factors and Interventions of Polycystic Ovary Syndrome Complicated With Depression and Anxiety	NCT04984070	PCOS (Polycysti... Depression, Anx...	Oral Contracept... Metformin Pill lifestyle inter...	18 Years - 40 Years	Fudan University
Treating Obese PCOS Patients With LSG vs. Met	NCT04508634	Polycystic Ovar...	laparoscopic sl... Metformin Pill	18 Years - 45 Years	Shanghai 10th People's Hospital

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