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R-MT followed by auto-HSCT Rituximab 375 mg/m2 d1 MTX 3.5g/m2 d2(0.5g/m2 15min,3g/m2 3h） TMZ 100 mg/m2 d2-6 Q21d\*4cycles

Auto-HSCT conditioning regimen:

BCNU 400mg/m2 d1; Thiotepa 5mg/kg q12h，d2-3

Four cycles of Induction therapy: Rituximab 375mg/m2 d1; Methotrexate 3.5g/m2 d2;Temozolomide 100mg/m2 d2-6; for patients who reach a CR, PR, or SD, will proceed to autologous stem cell transplantation: Carmustine 400mg/m2 d1; Thiotepa 5mg/kg q12h, d2-3.

R-MT followed by auto-HSCT

lijuan deng, MD

Yuqin Song, MD

Lijuan Deng, MD

Jun Zhu, MD

The purpose of this study is to evaluate the efficacy and safety of chemotherapy with MT-R followed by autologous stem cells transplantation in newly-diagnosed primary central nervous system lymphoma.

It's a single center, single arm, prospective clinical trial. Patients younger than 65 years old with primary central nervous system lymphoma will received four cycles of chemotherapy with rituximab plus high-dose methotrexate and temozolomide as induction therapy, and then received consolidation therapy with autologous stem cell transplant for which the conditioning regimen is Carmustine plus thiotepa.

MT-R Followed by Autologous Stem Cells Transplantation in Newly-diagnosed Primary Central Nervous System Lymphoma

using a battery of cognitive and quality-of-life (QoL) measures

Jun Zhu

Chief of the department of lymphoma

Anti-Infective Agents

Cytarabine

Vincristine

Procarbazine

Antiviral Agents

Tubulin Modulators

Antimitotic Agents

Comparative evaluation of the efficiency of a new protocol of the primitive LYMPHOME of the central nervous system ( LPSNC) to the old subject, associating Methotrexate and Temozolomide with regard to a standard protocol associating Methotrexate, Procarbazine, Vincristine and Cytarabine.

Methotrexate and temozolomide

Methotrexate , procarbazine ,vincristine ,cytarabine

Antonio OMURO, MD,PhD

Antonio OMURO, MD,

The purpose of this study is to evaluate two types of chemotherapy for primary central nervous system lymphoma in the elderly (age older than 60) :

* Methotrexate, procarbazine, vincristine and cytarabine
* Methotrexate and temozolomide

The aim of the study is to evaluate efficacy and toxicity associated with both protocols in this population, without radiotherapy.

Patients will be randomized to receive one of the two regimens in one of the participating centers. Neuropsychological evaluation will be performed in all patients. Patients will be followed with serial MRIs.

Methotrexate and Temozolomide Versus Methotrexate, Procarbazine, Vincristine and Cytarabine

Multicenter Randomized Phase II Study of Methotrexate (MTX) and Temozolomide Versus MTX, Procarbazine, Vincristine and Cytarabine for Primary CNS Lymphoma (PCNSL) in the Elderly

French Innovative Leukemia Organisation

Assistance Publique - Hôpitaux de Paris

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
MT-R Followed by Autologous Stem Cells Transplantation in Newly-diagnosed Primary Central Nervous System Lymphoma	NCT02399189	Primary Central...	R-MT followed b...	18 Years - 65 Years	Peking University
Methotrexate and Temozolomide Versus Methotrexate, Procarbazine, Vincristine and Cytarabine	NCT00503594	Lymphoma	Methotrexate an... Methotrexate , ...	60 Years -	Assistance Publique - Hôpitaux de Paris
Methotrexate and Temozolomide Versus Methotrexate, Procarbazine, Vincristine and Cytarabine	NCT00503594	Lymphoma	Methotrexate an... Methotrexate , ...	60 Years -	Assistance Publique - Hôpitaux de Paris
MT-R Followed by Autologous Stem Cells Transplantation in Newly-diagnosed Primary Central Nervous System Lymphoma	NCT02399189	Primary Central...	R-MT followed b...	18 Years - 65 Years	Peking University

Spots Global Cancer Trial Database for methotrexate and temozolomide