Spots Global Cancer Trial Database for Methotrexate and Temozolomide Versus Methotrexate, Procarbazine, Vincristine and Cytarabine
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Trial Identification
Brief Title: Methotrexate and Temozolomide Versus Methotrexate, Procarbazine, Vincristine and Cytarabine
Official Title: Multicenter Randomized Phase II Study of Methotrexate (MTX) and Temozolomide Versus MTX, Procarbazine, Vincristine and Cytarabine for Primary CNS Lymphoma (PCNSL) in the Elderly
Study ID: NCT00503594
Conditions
Study Description
Brief Summary: The purpose of this study is to evaluate two types of chemotherapy for primary central nervous system lymphoma in the elderly (age older than 60) : * Methotrexate, procarbazine, vincristine and cytarabine * Methotrexate and temozolomide
Detailed Description: The aim of the study is to evaluate efficacy and toxicity associated with both protocols in this population, without radiotherapy. Patients will be randomized to receive one of the two regimens in one of the participating centers. Neuropsychological evaluation will be performed in all patients. Patients will be followed with serial MRIs.
Eligibility
Minimum Age: 60 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Groupe hospitalier la Pitié Salpétrière, Paris, , France
Contact Details
Name: Antonio OMURO, MD,
Affiliation: Assistance Publique - Hôpitaux de Paris
Role: PRINCIPAL_INVESTIGATOR
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