Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Rare Diseases

Lung Neoplasms

Adenocarcinoma

Adenocarcinoma of Lung

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Lung Adenocarcinoma

Randomly assigned patients whose small pulmonary nodules are inflated with the diluted OCT medium (2:3) used for frozen section, and then detected under microscope for their histopathological characteristics, by immunostaining for specific protein expression, by NGS (next-generation sequencing) for driver mutations.

Randomly assigned patients whose small pulmonary nodules are uninflated with OCT used for frozen section, and then detected under microscope for their histopathological characteristics, by immunostaining for specific protein expression, by NGS for driver mutations.

Detection of of histopathological characteristics of OCT treatment or OCT free samples from patients .

microscope

Detection of CD31/CD34, D2-40, Ki67 and p53 immunostaining of OCT treatment or OCT free samples from patients .

immunostaining

The investigators used the device to detect the gene mutations of OCT treatment or OCT free samples obtained from part of the patients.

Jie Zhang, MD, MS

Keke Yu, MD, PhD

Jie Zhang, MD, MS.

The purpose of this study is:

1. To establish a set of diagnostic criteria of intraoperative frozen section of early stage lung adenocarcinoma, including clinicopathologic and molecular characteristics.
2. To assess its clinical usefulness in guiding surgical procedure for early stage lung adenocarcinoma.

The detection rate of small pulmonary nodules is increasing due to the widespread use of high-resolution computed tomography (CT) screening in clinical practice. These minute pulmonary nodules are suggestive of atypical adenomatous hyperplasia (AHH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma. Hence, the precision diagnosis of intraoperative frozen section is particularly imperative for its fundamental role in assess indeterminate lung lesions and guide the extent of subsequent surgical procedure.

However, it is still difficult for the surgical pathologist to apply the various features according to the newly revised WHO classification of lung adenocarcinoma (2015) to guide surgical management due to their unascertained accuracy or heterogeneity of lung cancer or technique problem. Therefore, the establishment and assessment for a set of diagnostic criteria of intraoperative frozen section of early stage lung adenocarcinoma are our primary aim in this study.

Precision Diagnosis for Intraoperative Frozen Section of Early Stage Lung Cancer

Establishment and Evaluation for Pathological Diagnostic Criteria of Intraoperative Frozen Section of Early Stage Lung Cancer

Shanghai Chest Hospital

Chief Physician

Digestive System Diseases

Liver Diseases

Liver Neoplasms

Hepatic Insufficiency

Liver Failure

Gastrointestinal Diseases

Gastrointestinal Neoplasms

Digestive System Neoplasms

Hematinics

All Drugs and Chemicals

Liver Extracts

In this group , patients will undergo biliary reconstruction using surgical loupe

In this group , patients will undergo biliary reconstruction using microscope

Biliary reconstruction will be performed using surgical loupe

Surgical Loupes

Biliary reconstruction will be performed using microscope

Microscope

Comparison of biliary complications in right lobe living donor liver transplantation patients undergoing biliary reconstructions using microscope versus surgical loupes .

Liver transplantation (LT) is the most effective treatment modality in patients with end-stage liver disease and it is also established as a viable treatment option in the field of oncology. Living donor liver transplantation (LDLT) using the right lobe (RL) is a major achievement despite its technical challenges, which has created a significant increase in graft supply. While a secure bile duct anastomosis is one of the basic principles of a successful liver transplant procedure, biliary reconstruction remains the Achilles' heel of LDLT because of the high incidence of posttransplant biliary complications associated with significant recipient morbidity and mortality. Some of these complications are related to technical difficulties due to multiple small biliary orifices, particularly in right lobe grafts. In our center, we have been using microsurgical reconstruction technique for duct-to-duct biliary anastomosis in such grafts. The routine use of this technique has been shown to significantly decrease biliary complications in single-center retrospective studies. However, prospective controlled studies comparing microsurgical and standard biliary reconstruction techniques are lacking. In this study, our objective is to compare posttransplant complications of the two techniques of biliary reconstruction in RL LDLT.

40 patients will be included in the study. They will be randomly allocated in the equal groups.İn group 1 biliary anastomosis will be performed using surgical loupes and İn group 2 biliary anastomosis will be performed using microscope. The patients will be followed for one year after the transplant to compare biliary complications.

The patients will be randomly allocated in the equal groups.İn group 1 biliary anastomosis will be performed using surgical loupes and İn group 2 biliary anastomosis will be performed using microscope.

Biliary Anastomosis Using Surgical Loupe Versus Microscope in Living Donor Liver Transplantation

Prospective Randomized Single-center Trial Comparing Biliary Anastomosis Using Surgical Loupe Versus Microscope in Living Donor Liver Transplantation

Incidence of biliary complications after living donor liver transplantation

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Precision Diagnosis for Intraoperative Frozen Section of Early Stage Lung Cancer	NCT02941003	Lung Cancer	microscope immunostaining NGS	40 Years - 70 Years	Shanghai Chest Hospital
Biliary Anastomosis Using Surgical Loupe Versus Microscope in Living Donor Liver Transplantation	NCT04618692	Liver Failure Liver Diseases Liver Cancer Liver Neoplasms Liver Dysfuncti...	Surgical Loupes Microscope	18 Years - 75 Years	Istanbul Medipol University Hospital
Biliary Anastomosis Using Surgical Loupe Versus Microscope in Living Donor Liver Transplantation	NCT04618692	Liver Failure Liver Diseases Liver Cancer Liver Neoplasms Liver Dysfuncti...	Surgical Loupes Microscope	18 Years - 75 Years	Istanbul Medipol University Hospital

Spots Global Cancer Trial Database for microscope

Every month we try and update this database with for microscope cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for microscope

Every month we try and update this database with for microscope cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for microscope cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.