Symptoms and General Pathology

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Skin and Connective Tissue Diseases

Hemorrhage

Myoma

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Neoplasms by Histologic Type

Neoplasms, Connective Tissue

Connective Tissue Diseases

Gastrointestinal Agents

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All Drugs and Chemicals

Misoprostol

Antacids

Anti-Ulcer Agents

misoprostol group ( study group ) ( 25 patient): who will receive 400 microgram (tablet 200mcg X 2) misoprostol rectally one hour before operation

( 25 patient): who will receive placebo . two rectal placebo tablet of the same size and shape as the misoprostol.

( 25 patient): who will receive 400 microgram (tablet 200mcg X 2) misoprostol rectally one hour before operation

( 25 patient): who will receive placebo . two rectal placebo tablet of the same size and shape as the misoprostol

Placebos

dina yahia mansour, MD

aziza mohamed, master

abd el fatah soaod, professor

sabry sayed, professor

assess the effect of using misoprostol in abdominal myomectomy operations on blood loss, duration of the operation and possible operative complications. Research question Does pre-operative misoprostol affect on intra-operative blood loss during and after myomectomy operation ?. Research hypothesis Pre-operative misoprostol may reduce intra-operative blood loss during and after myomectomy operation .

. Type of Study : Prospective double blind randomized placebo controlled clinical trial.

* Study Setting : This study will be conducted in Ain Shams University Maternity hospital.
* Study Period : 6 months
* Study Population : Patients will be recruited in this study those attending gynecology ward at Ain Shams University Maternity hospital who are 25-50 years old with symptomatic uterine myoma

Methodology

All women will be subjected to:

History taking:

It includes name, age, occupation, marriage and special habits,last menstrual period, menstrual history, history of present illness ( symptoms related to myoma ), any medical disorders and any previous surgeries.

Examination

General examination:

It includes blood pressure, heart rate and body temperature, body mass index, head\& neck examination Bilateral lower limb examination.

Abdominal examination:

It includes:

1. Inspection : pelvi-abdominal swelling
2. Palpation : smooth or irregular surface - mobility - consistency - size - tenderness
3. Auscultation : soufflé ( increased vascularity )
4. Percussion : dullness

Local examination:

Vaginal examnation will be done to detect uterine swelling with transmitted movement to the cervix . if movement not transmitted to cervix , it revealed extra-uterine swelling , also examination of adnexa Investigations Ultrasonography ( abdominal / vaginal ), (hysteroscopy , MRI , D\&C if indicated ) Pre-operative investigation ( Complete blood picture, blood group , RH, hematocrite , Kidney Function Test , Liver Function Test , random Blood Sugar , urine analysis Intervention

All women will be randomly assigned to either:

Group A ( study group ) ( 25 patient): who will receive placebo . two rectal placebo tablet of the same size and shape as the misoprostol.

Group B (control group ) ( 25 patient): who will receive 400 microgram (tablet 200mcg X 2) misoprostol rectally one hour before operation

In all operations, the abdomen is entered by a Pfannenstiel incision. The operations are performed by the same team to avoid any bias related to surgical skills. The total volume of intra-operative blood loss is estimated by measuring the amount of blood accumulated in the suction container and the amount of blood on the surgical gauze by gauze weighting, the surgical gauzes are weighted before and after surgery using a scale accurate to 1 gram and the weight difference was calculated. The weight of 1 gram is taken as 1 ml blood.

Vital data during operation and the duration of the operation are recorded (time from opening of the peritoneum until its closure). The postoperative haemoglobin level is measured for each participant 24 h after the operation. Records are kept for any intra-operative or postoperative blood transfusion. Any postoperative adverse events, including any febrile episode (increase to or over 38.5°C in body temperature within 24 h following surgery) are documented. Also post operative vital data will be recorded

Intervention

All women will be randomly assigned to either:

Group A ( study group ) ( 25 patient): who will receive placebo . two rectal placebo tablet of the same size and shape as the misoprostol.

Group B (control group ) ( 25 patient): who will receive 400 microgram (tablet 200mcg X 2) misoprostol rectally one hour before operation

the Effect of Misoprostol on Intra-operative Blood Loss During Myomectomy Operation

reduce intra operative blood loss during myomectomy

ahmed nagy shaker ramadan

resident of obstetric and gynecology

Natriuretic Agents

Vasoconstrictor Agents

Coagulants

Vasopressins

Arginine Vasopressin

Use of laparoscopic injection of diluted vasopressin (20units in 100mL 0.9NS) prior to incision throughout the myomectomy.

Use of laparoscopic injection of diluted vasopressin (20units in 100mL 0.9NS) prior to incision throughout the myomectomy. 400mcg of misoprostol placed in the vagina at HUMI/foley placement .

20 units diluted in 100mL of Normal Saline injected laparoscopic needle

Standard

20 units diluted in 100mL of Normal Saline injected laparoscopic needle and misoprostol 400 mcg

Standard-vaginal misoprostol

Pedram Bral, M.D.

Injection of Vasopressin into the uterine tissue surrounding fibroids constricts blood vessels, and has been found to be beneficial by decreasing blood flow to fibroids, and thereby resulting in less bleeding with removal. Additionally, Misoprostol has been looked at as an additional method to decrease operative blood loss given its ability to increase uterine muscle tone, which therefore constricts the amount of blood flow to the uterus.

Uterine fibroids are common benign tumors affecting women, and produce symptoms severe enough to warrant treatment in 20-50% of reproductive age women, including abnormal uterine bleeding, pelvic pain, and infertility. While hysterectomy with removal of the uterus is standard of care for symptomatic uterine fibroids, women desiring future child bearing require removal of the fibroids alone via uterine myomectomy, with re-construction of the uterus after removal. A well established risk to such a procedure is the operative blood loss, which can be quite significant due to the increased blood supply fibroids accumulate. Several interventions have been looked at as potential methods to help decrease operative blood loss. Injection of Vasopressin into the uterine tissue surrounding fibroids constricts blood vessels, and has been found to be beneficial by decreasing blood flow to fibroids, and thereby resulting in less bleeding with removal. A known potential side effect of vasopressin is cardiovascular compromise, which can be catastrophic if vasopressin is inadvertently injected into the large vessels of the uterus. This limits the amount that can be safely used in surgery. Additionally, Misoprostol has been looked at as an additional method to decrease operative blood loss given its ability to increase uterine muscle tone, which therefore constricts the amount of blood flow to the uterus. While Vasopressin is more commonly used during surgery, the associated potential risks limit the amount that can be safely administered. However, the addition Misoprostol, with a relatively safe side effect profile, can further improve control of the blood supply and decrease operative blood loss. Misoprostol can be administered orally, sublingually, or as vaginal or rectal suppositories. While the systemic absorption of vaginal Misoprostol is slower in onset than the oral or sublingual routes, the effect is maintained for a longer period of time, and is more conducive to use during laparoscopic or robotic assisted myomectomies given the prolonged operative time associated with minimally invasive techniques when compared to traditional open approaches. This study aims to determine whether using vaginal Misoprostol in combination with Vasopressin is more effective at decreasing operative blood loss during robotic assisted laparoscopic myomectomy than Vasopressin alone.

Combined Vaginal Misoprostol and Perivascular Vasopressin

A Randomized Control Trial of Combined Vaginal Misoprostol and Perivascular Vasopressin During Robotic Myomectomy

The difference in hemoglobin levels between pre surgery and post surgery

Antonios Likourezos

Research Administration Director

Use of laparoscopic injection of diluted vasopressin (20units in 100mL 0.9NS) prior to incision throughout the myomectomy.

Standard-vaginal misoprostol: 20 units diluted in 100mL of Normal Saline injected laparoscopic needle and misoprostol 400 mcg

Use of laparoscopic injection of diluted vasopressin (20units in 100mL 0.9NS) prior to incision throughout the myomectomy. 400mcg of misoprostol placed in the vagina at HUMI/foley placement .

Standard: 20 units diluted in 100mL of Normal Saline injected laparoscopic needle

Standard-vaginal misoprostol: 20 units diluted in 100mL of Normal Saline injected laparoscopic needle and misoprostol 400 mcg

Standard-Vaginal Misoprostol

Total

Age, Continuous

Sex: Female, Male

Race and Ethnicity were not collected from any participant.

Race and Ethnicity Not Collected

United States

Region of Enrollment

Pedram Bral, MD

Hemoglobin Levels Difference Between Pre and Post Surgery.

Overall Study

Blood Loss, Surgical

25 patients undergoing myomectomy operation will receive two tablets of misoprostol (400 mcg) rectally two hours before the operation.

Include 25 patients undergoing myomectomy operation will not receive misoprostol before the operation.

25 patients undergoing myomectomy operation will receive two tablets of misoprostol (400 mcg) rectally two hours before the operation

Placebo( for misoprostol)

Abd El Mgeed I. Abd El Mgeed, Professor

Mohamed S. Ali, Professor

Mohamed A. Abdel-Hafeez, Lecturer

Mina A. Yacoup, Fellow

Ahmed M. Elnaggar, Lecturer

The aim of this research work is to assess the effect of using single preoperative dose of rectal misoprostol in abdominal myomectomy operations on blood loss, duration of the operation and possible operative complications

This study is a randomized, double-blind, controlled study that will be conducted in Ain Shams University Maternity Hospital.

A total of 50 women scheduled to undergo myomectomy for symptomatic uterine myoma will be included in this study after taking their consent for this clinical trial after full explanation of the trial.

The total of 50 included patients will be divided into two groups: Group A (Study group;): will Include 25 patients undergoing myomectomy operation will receive two tablets of misoprostol (400 mcg) rectally two hours before the operation.Group B (Control group): will Include 25 patients undergoing myomectomy operation will not receive misoprostol before the operation.

Impact of Misoprostol on Blood Loss In Myomectomy Operations

Phase 1 Study of Misoprostol in Reducing Intraoperative Bleeding in Myomectomy Operations

Ain Shams University

Micronutrients

Hematinics

Vitamins

Vitamin B 6

Pyridoxal

Pyridoxine

Vitamin B Complex

Trace Elements

Folic Acid

Vitamin B6

Folate

Vitamin B9

25 patients undergoing abdominal myomectomy operation will receive two tablets of misoprostol (400 mcg) buccally one hour before the operation.

25 patients undergoing abdominal myomectomy operation will receive two tablets of Vitamin B6 (100mg) buccally one hour before the operation.

Placebo

Magdy Milad, MD

The aim of this research work is to assess the impact of a single preoperative dose of buccal misoprostol in reducing blood loss during abdominal fibroid surgery.

This is a trial of women undergoing fibroid surgery at a university-affiliated tertiary care center. Eligible participants will be randomized to receive preoperative 400ucg buccal (under the tongue) misoprostol or placebo on the basis of total fibroid volume, location, parity. Intra-operative blood loss will be compared between groups.

Misoprostol for Reduction of Blood Loss During Fibroid Surgery

Buccal Misoprostol Prior to Abdominal Myomectomy for Reduction of Intraoperative Blood Loss: A Randomized Placebo-Controlled Trial

Estimate of blood loss occurring during the surgical procedure as determined by anesthesia staff and documented by anesthesia, nursing and surgical staff as per hospital protocol.

Participants will be followed for the duration of their stay, defined as the number of days of post-operative inpatient hospitalization, an expected average of 3 days.

Whether or not a patient receives a post-operative blood transfusion, defined as a transfusion occurring in the immediate post-operative period (during post-operative inpatient hospitalization).

Northwestern University

Professor in Obstetrics and Gynecology, Reproductive Endo & Infertility

25 patients undergoing abdominal myomectomy operation will receive two tablets of misoprostol (400 mcg) buccally one hour before the operation.

Misoprostol: 25 patients undergoing abdominal myomectomy operation will receive two tablets of misoprostol (400 mcg) buccally one hour before the operation.

25 patients undergoing abdominal myomectomy operation will receive two tablets of Vitamin B6 (100mg) buccally one hour before the operation.

Placebo: 25 patients undergoing abdominal myomectomy operation will receive two tablets of Vitamin B6 (100mg) buccally one hour before the operation.

Age, Categorical

Dr. Magdy Milad

Estimated Intra-operative Blood Loss

13 patients undergoing abdominal myomectomy operation will receive two tablets of misoprostol (400 mcg) buccally one hour before the operation.

Misoprostol: 13 patients undergoing abdominal myomectomy operation will receive two tablets of misoprostol (400 mcg) buccally one hour before the operation.

26 patients undergoing abdominal myomectomy operation will receive two tablets of Vitamin B6 (100mg) buccally one hour before the operation.

Placebo: 26 patients undergoing abdominal myomectomy operation will receive two tablets of Vitamin B6 (100mg) buccally one hour before the operation.

Duration of Procedure

Length of Inpatient Hospitalization

Post-operative Blood Transfusion

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Infertility

Polyps

Uterine Neoplasms

Pathological Conditions, Anatomical

Genital Diseases

Urogenital Diseases

Genital Neoplasms, Female

Urogenital Neoplasms

Uterine Diseases

Genital Diseases, Female

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

HENRY A MATEO-SÁNEZ, MD

Endometrial polyps are one of the main causes of infertility in women. In this work we propose an alternative, effective, economical and safe treatment: the use of misoprostol

The prevalence of uterine polyps has been estimated in the general population at 10-15%, while in infertile patients it ranges from 6-32%. Its etiology is considered as multifactorial. Polyps induce a local inflammatory response in the endometrial cavity, causing infertility. The treatment of choice considered "gold standard" is the excision by hysteroscopy, however, improvement has been shown in patients with conservative management due to the regression rate of 27%. There are no recommended drugs to provide a definitive treatment for uterine polyps. Misoprostol is a synthetic analogue derived from prostaglandin E1 that has stimulating effects on the smooth muscle fibers of the uterus, causing contractions of the myometrium, which cause endouterine evacuation. The present study shows a possible utility of misoprostol for the conservative treatment of uterine polyps.

Misoprostol as a Treatment for Endometrial Polyps in Infertile Patients

Misoprotol as a Treatment for Endometrial Polyps in Infertile Patients

Henry Aristoteles Mate-Sánez

Principal Investigator

Central Nervous System Depressants

Anesthetics

Oxytocin

receiving a preoperative rectal dose of 800 ug of misoprostol half an hour before surgery

After the induction of general anaesthesia (GA), an infusion of 40 IU oxytocin in 500 ml normal saline was started at the rate of 250 ml/hour

Misoprostol 200mcg Tab

after the induction of general anaesthesia (GA), an infusion of 40 IU oxytocin in 500 ml normal saline was started at the rate of 250 ml/hour

waleed M El-khayat, MD

mona s Moghazy, MD

Mohammad A Taymour, MD

Waleed M Elkhyat

Tarek N Anees, MD

Uterine leiomyomas, or fibroids, are common benign tumors among women, especially those over 35 years old. They can cause various issues, including heavy menstrual bleeding, anemia, pelvic pain, and pressure symptoms. Surgery is often necessary for symptomatic fibroids, with hysterectomy recommended for women over 40 and myomectomy for those wishing to preserve their uterus. Myomectomy can be performed using different surgical approaches but can be associated with significant morbidity, particularly major blood loss, especially in abdominal myomectomy, where up to 20% of women may require blood transfusion.

Various interventions have been introduced to reduce bleeding during myomectomy, such as tourniquets, bupivacaine plus epinephrine infiltration, vasopressin injection, preoperative GnRH agonist administration, and preoperative ascorbic acid injection. However, these strategies may have complications, be ineffective, expensive, or require extra steps.

Oxytocin, primarily secreted from the pituitary gland, is crucial for uterine contraction during labor and delivery, and is used to prevent postpartum uterine atony and bleeding. However, caution is needed in its use, especially in women with heart disease or hypovolemia.

Misoprostol, a prostaglandin E1 analogue, can reduce bleeding during myomectomy by promoting myometrial contractions and reducing uterine artery blood flow. It can be administered via multiple routes, with rectal administration showing advantages in maintaining high plasma concentrations during surgery. Studies have investigated the effectiveness of single preoperative rectal doses of misoprostol versus preoperative oxytocin in reducing bleeding during abdominal myomectomy.

20-48 years old with symptomatic uterine myoma indicating operative management, abnormal uterine bleeding or bulk-related symptoms, females with infertility or recurrent pregnancy loss, pressure symptoms, and large myoma(s).

Misoprostol Versus Oxytocin Infusion On Reducing Blood Loss During Abdominal Myomectomy

The Efficacy Of Misoprostol Versus Oxytocin Infusion On Reducing Blood Loss During Abdominal Myomectomy

which was measured at the end of surgery by calculating the sum of blood in the suction bottle and the blood absorbed in the sponges. Dry sponges were weighed before the surgery and the blood-soaked sponges were weighed at the end of the surgery

Cairo University

lecturer

Intraoperative Complications

In study group, 400ug misoprostol will be administered through rectal route, 1 hour before surgery.

In control group no dose will be administered

400ug misoprostol will be administered through rectal route, 1 hour before surgery to assess its effect on intra-operative blood loss during myomectomy

Salma Nisar

A total of 200 women for elective abdominal myomectomy were randomly allocated into two groups.

100 women in experimental group were administered 400ug Misoprostol (2 tablets of Prosotec®) through the rectal route prior to surgery and 100 were in control group, in which no drug was administered.

After getting approval from hospital's ethical committee, patients eligible for the study were recruited in the study according to the selection criteria. Before surgery, after taking informed written consent, patient's detailed history including demographics, parity \& BMI was recorded. Uterine size was assessed by bimanual pelvic examination. Patients undergoing myomectomy were randomly divided into 2 groups using lottery method. In experimental group Misoprostol 400ug was administered per rectally prior to surgery. In control group, no drug was administered.

The surgical procedural elements, the surgeon or surgeons performing the procedure and the use of antibiotics as well as anesthetic agents was standardized to remove any bias. Intraoperative blood loss was recorded by a single trained doctor and calculated using visual scale for the abdominal sponges and chest swabs/gauzes used during surgery and blood collected in suction bottle.

There will be a single trained person who calculated the intra-operative blood loss and was blinded to the randomization of the patients and the use of medication.

Effect of Rectal Misoprostol in Reducing Intra-operative Blood Loss During Myomectomy

Effect of Rectal Misoprostol in Reducing Intra-operative Blood Loss During Myomectomy A Randomized Control Trial

Intraoperative blood loss will be recorded by a trained doctor and calculated using visual scale for the abdominal sponges and chest swabs/gauzes used during surgery and blood collected in suction bottle.

Pak Emirates Military Hospital

Resident OBGYN

Dinoprostone

Will receive 20 mg of Dinoprostone vaginally 2 hrs. preoperatively.

will receive 400 μg of Misoprostol vaginally 2 hrs. preoperatively.

received a placebo vaginally 2 hrs. preoperatively.

Beni-Suef University

Aim and objectives; To compare the efficacy of preoperative administration of dinoprostone 20 mg versus 400 ug misoprostol vaginally in decreasing the amount of bleeding during abdominal myomectomy

Background; Myomectomy is a curative interventional option for many kinds of uterine fibroids, but considerable intraoperative haemorrhage and the necessities for transfusions of blood are still the main challenge for abdomen myomectomy.

Aim and objectives; To compare the efficacy of preoperative administration of dinoprostone 20 mg versus 400 ug misoprostol vaginally in decreasing the amount of bleeding during abdominal myomectomy Subjects and methods; This was a prospective randomized double-blind controlled study that included 90 patients complaining of uterine myoma and indicated for myomectomy selected from the outpatient clinic at Beni-suef university hospital

Preoperative Vaginal Dinoprostone Versus Misoprostone in Abdominal Myomectomy

Preoperative Vaginal Dinoprostone Versus Misoprostone to Decrease Bleeding During Abdominal Myomectomy

quantity of blood collected in the aspiration apparatus and the quantity of blood on the operative gauze.

Lecturer of Gynecology and obstetrics Faculty of medicine Beni-Suef University

Pharmaceutical Solutions

Vasodilator Agents

Platelet Aggregation Inhibitors

Urological Agents

Amino Acids

Alprostadil

Hemostatics

Arginine

20 cases received 400 microgram prostaglandin E1 analogue, misoprostol, (Misotac®, 200 microgram, by SIGMA pharmaceutical industries, Alexandria, Egypt), intra-vaginally, 2 hr before operation.

20 patients who had hysteroscopic guided intralesional vasopressin injection before hysteroscopic myomectomy

prostaglandin E1 analogue vaginally inserted two hours before hystertsopic myomectomy to evaluate intraoperative blood loss and operative time needed for completion of myomectomy

one ampoule of vasopressin was diluted to 50 ml of normal saline, and 10 ml (4 units of vasopressin) was withdrawn in a syringe. Needle was inserted through the working channel of the hysteroscope until its tip was seen. The needle tip was pointed to the site of injection under hysteroscopic guidance during the whole injection technique. Aspiration was done first to avoid intravascular injection of vasopressin. The diluted solution was injected into the surface, especially to parts with dilated vasculature till they blanch.

Vasopressin

A prospective randomized study designed to compare the efficacy of transcervical vasopressin injection versus vaginal misoprostol in reducing intra -operative blood loss during hysteroscopic mymectomy .

This was a prospective, randomized, study on forty women with symptomatic submucous myoma presented mostly with bleeding and/or infertility scheduled for hysteroscopic myomectomy were randomized to groups (group A) 20 patients transcervical intramyoma vasopressin injection and (group B) 20patients with vaginal misoprostol is used .

Yes: Eligibility is based on gender, As the subject of the study is hysterscopic myomectomy so the the clinical trial is based on female gender

Vasopressin Injection Versus Misoprostol During Hysteroscopic Myomectomy In Reducing Blood Loss And Operation Time.

Efficacy of Transcervical Vasopressin Injection VersusVaginal Misoprostol During Hysteroscopic Myomectomy in Reducing Operative Blood Loss and Operation Time: A Randomized Trial.

subjective assessment of bleeding by the surgeon.

time needed for completion of myomectomy procedure

haemoglobin and hematocrit values before and after myomectomy

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
the Effect of Misoprostol on Intra-operative Blood Loss During Myomectomy Operation	NCT03483142	Myoma;Uterus Blood Loss	Misoprostol Placebos	25 Years - 50 Years	Ain Shams Maternity Hospital
Combined Vaginal Misoprostol and Perivascular Vasopressin	NCT03815344	Leiomyoma Laparoscopy Uterine Myomect...	Standard Standard-vagina...	18 Years - 55 Years	Maimonides Medical Center
Impact of Misoprostol on Blood Loss In Myomectomy Operations	NCT02061657	Leiomyoma	Misoprostol Placebo( for mi...	35 Years - 50 Years	Ain Shams University
Misoprostol for Reduction of Blood Loss During Fibroid Surgery	NCT02209545	Fibroids	Misoprostol Placebo	18 Years - 50 Years	Northwestern University
Combined Vaginal Misoprostol and Perivascular Vasopressin	NCT03815344	Leiomyoma Laparoscopy Uterine Myomect...	Standard Standard-vagina...	18 Years - 55 Years	Maimonides Medical Center
Misoprostol as a Treatment for Endometrial Polyps in Infertile Patients	NCT04270994	Endometrial Pol...	Misoprostol	18 Years - 45 Years	Mateo-Sánez, Henry A.
Misoprostol Versus Oxytocin Infusion On Reducing Blood Loss During Abdominal Myomectomy	NCT06325501	Myoma;Uterus	Misoprostol 200... Oxytocin	20 Years - 48 Years	Cairo University
Effect of Rectal Misoprostol in Reducing Intra-operative Blood Loss During Myomectomy	NCT05108597	Blood Loss, Sur... Uterine Myoma	Misoprostol	18 Years - 50 Years	Pak Emirates Military Hospital
Impact of Misoprostol on Blood Loss In Myomectomy Operations	NCT02061657	Leiomyoma	Misoprostol Placebo( for mi...	35 Years - 50 Years	Ain Shams University
Misoprostol as a Treatment for Endometrial Polyps in Infertile Patients	NCT04270994	Endometrial Pol...	Misoprostol	18 Years - 45 Years	Mateo-Sánez, Henry A.
the Effect of Misoprostol on Intra-operative Blood Loss During Myomectomy Operation	NCT03483142	Myoma;Uterus Blood Loss	Misoprostol Placebos	25 Years - 50 Years	Ain Shams Maternity Hospital
Preoperative Vaginal Dinoprostone Versus Misoprostone in Abdominal Myomectomy	NCT05761418	Myoma;Uterus	Dinoprostone Misoprostol	30 Years - 50 Years	Beni-Suef University
Vasopressin Injection Versus Misoprostol During Hysteroscopic Myomectomy In Reducing Blood Loss And Operation Time.	NCT03930069	Submucous Leiom...	Misoprostol Vasopressin	18 Years - 40 Years	Zagazig University
Misoprostol Versus Oxytocin Infusion On Reducing Blood Loss During Abdominal Myomectomy	NCT06325501	Myoma;Uterus	Misoprostol 200... Oxytocin	20 Years - 48 Years	Cairo University

Spots Global Cancer Trial Database for misoprostol

Every month we try and update this database with for misoprostol cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for misoprostol

Every month we try and update this database with for misoprostol cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for misoprostol cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.