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Nasopharyngeal Neoplasms

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The participant who is found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy in Sun Yat-Sen University Cancer Center. The physicians in Sun Yat-Sen University Cancer Center consider it necessary to perform an endoscopic image-guided biopsy.

The participant who is found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy in Guangdong Provincial People's Hospital. The physicians in Guangdong Provincial People's Hospital consider it necessary to perform an endoscopic image-guided biopsy.

The participant who is found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy in Nanfang Hospital. The physicians in Nanfang Hospital consider it necessary to perform an endoscopic image-guided biopsy.

The participant who is found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy in Fujian Provincial Cancer Hospital. The physicians in Fujian Provincial Cancer Hospital consider it necessary to perform an endoscopic image-guided biopsy.

The participant who is found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy in Hainan Provincial People's Hospital. The physicians in Hainan Provincial People's Hospital consider it necessary to perform an endoscopic image-guided biopsy.

For each participant presenting with a suspicious nasopharyngeal lesion, the attending physician will assess the lesion and determine the appropriate biopsy approach. The physician may decide on multiple biopsies from the lesion area, including one sample from within the lesion itself, another from 5-8 mm outside the lesion, and a third from 8-10 mm beyond the lesion. Alternatively, a single biopsy may be deemed sufficient based on the clinical judgment. Each of these specimens will undergo pathological examination to confirm whether they are carcinomatous or non-carcinomatous.

Nasopharyngeal Endoscopy image-guided Biopsy

Di Dong, Ph.D

Yali Zang, ph.D

Sufang Qiu

Zhongming Lu

Xiong Liu

Linglong Tang

Feng Chen

Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperplasia, the positive rate for nasopharyngeal carcinoma identification during biopsy is low, thus leading to delayed or missed diagnosis for nasopharyngeal carcinoma upon initial attempt. Here, we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies and guide biopsy under endoscopic examination based on deep learning.

For each participant exhibiting suspicious lesions during a nasopharyngeal endoscopy examination, the attending physician will determine the appropriate biopsy strategy based on the specific conditions of the lesion. The physician may opt for a single biopsy, taking a sample directly from within the lesion, or multiple biopsies, which would include one sample from inside the lesion, another from 5-8 mm outside the lesion, and a third from 8-10 mm outside the lesion. This decision will be grounded in clinical judgment and a comprehensive consideration of optimal diagnostic outcomes and patient safety.

Detection and Biopsy Guidance of Nasopharyngeal Carcinoma Based on Artificial Intelligence and Endoscopic Images

Detection and Biopsy Guidance of Nasopharyngeal Carcinoma Based on Artificial Intelligence and Endoscopic Images：a Multi-center Prospective Study

Statistical significance (P value) of DFS (time from diagnosis to disease progression or death from any cause) in nasopharyngeal carcinoma patients between high-risk and low-risk group identified by deep learning-based model.

AUC of an deep learning-based model in discriminating nasopharyngeal carcinoma from bengin lesion.

The agreement between the deep learning-based model and the histopathological diagnosis of the three biopsy specimens (inside the lesion, 5-8 mm outside the lesion, and 8-10 mm outside the lesion).

Sun Yat-sen University

Guangdong Provincial People's Hospital

Nanfang Hospital, Southern Medical University

Fujian Cancer Hospital

Hainan People's Hospital

Chinese Academy of Sciences

Professor

Mouth Neoplasms

Mouth Diseases

Oral Cancer

Lip and Oral Cavity Cancer

Low-cost, flexible scope prototype will compared to standard of care scope used as standard of care.

Nasopharyngoscope

Walter Lee, MD

This study aims to develop and evaluate a low-cost, portable, flexible nasopharyngeal scope (FNS) used to assess head and neck cancers (HNC) in low resource settings. The FNS will be compared to an endoscope that is used as standard of care (SOC) in terms of ease of use, image quality, and perceived pain. The ultimate goal is to compare the ease of use between the FNS to what is used in SOC.

Low-Cost, Portable Flexible Nasopharyngoscope in Head & Neck Cancers in Low Resource Settings - Optimization Phase

Partnership to Establish a Practice Based Network to Assess for Head and Neck Cancers Using a Low-Cost Portable Flexible Nasopharyngoscope - Optimization Phase

Measured using a 5 point scale, with 1 = Very hard, 2=Harder, 3 = Same, 4= Easier and 5 = very easy

Measured using 5 point scale, with 1 being poor and 5 being excellent

Comparison using a 3 point scale, with 1 being much more and 3 being much less

measured by a provider questionnaire following completion of flexible scope exam

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Detection and Biopsy Guidance of Nasopharyngeal Carcinoma Based on Artificial Intelligence and Endoscopic Images	NCT05202626	Nasopharyngeal ... Image-Guided Bi...	Nasopharyngeal ...	18 Years -	Chinese Academy of Sciences
Detection and Biopsy Guidance of Nasopharyngeal Carcinoma Based on Artificial Intelligence and Endoscopic Images	NCT05202626	Nasopharyngeal ... Image-Guided Bi...	Nasopharyngeal ...	18 Years -	Chinese Academy of Sciences
Low-Cost, Portable Flexible Nasopharyngoscope in Head & Neck Cancers in Low Resource Settings - Optimization Phase	NCT04905134	Head and Neck C... Oral Cancer	Nasopharyngosco...	18 Years -	Duke University

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