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Hypopharyngeal Cancer

Neck dissection followed by radiotherapy(50Gy) according to risk factors

Definitive radiotherapy

Yuansheng Duan, MD

Ze Zhang, MD

Xudong Wang, Ph.D

At the time of diagnosis, approximately 60%-80% of patients with hypopharyngeal cancer are found with cervical lymph node metastasis. Cervical nodal metastasis is an important prognostic factor in hypopharyngeal cancer. Induction chemotherapy is frequently used in advanced hypopharynx cancer. However, sometimes CR was obtained at the tumor's primary site but not in the palpable lymph nodes in the neck, the large cervical lymph node metastasis poorly responded to induction chemotherapy in a considerable percentage of patients. At present, patients with primary tumor achieved CR preferred to receive definitive radiotherapy no matter cervical lymph node metastasis SD or progression. But, radiotherapy was poor effective to the big cervical lymph node metastasis, because the inner of big cervical lymph node metastasis was hypoxic and necrosis. The investigators conducted a prospective, randomised trial to compare neck dissection with definitive radiotherapy for advanced hypopharyngeal cancer cervical lymph node metastasis with poor response to induction chemotherapy.

Neck Dissection vs Radiotherapy for Cervical Metastases in Advanced Hypopharyngeal Cancer

Neck Dissection Versus Radiotherapy for Cervical Lymph Node Metastasis in Advanced Hypopharyngeal Carcinoma With Poor Response to Induction Chemotherapy : A Randomized Controlled Prospective Study

The percentage of patients without cervical lymph node metastasis

The proportion of patients did not find clear evidence of recurrence or metastasis

Evaluated by the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30

Evaluated by the European Organization for Research and Treatment of Cancer(EORTC) QLQ-HN35

Tianjin Medical University Second Hospital

Tianjin Medical University General Hospital

Tianjin Medical University Cancer Institute and Hospital

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Neck Dissection vs Radiotherapy for Cervical Metastases in Advanced Hypopharyngeal Cancer	NCT03367884	Hypopharyngeal ...	Neck dissection... Definitive radi...	18 Years - 75 Years	Tianjin Medical University Cancer Institute and Hospital
Neck Dissection vs Radiotherapy for Cervical Metastases in Advanced Hypopharyngeal Cancer	NCT03367884	Hypopharyngeal ...	Neck dissection... Definitive radi...	18 Years - 75 Years	Tianjin Medical University Cancer Institute and Hospital

Spots Global Cancer Trial Database for neck dissection followed by radiotherapy(50gy) according to risk factors