Neoplasms

Nervous System Diseases

All Conditions

Rare Diseases

Brain Neoplasms

Central Nervous System Neoplasms

Nervous System Neoplasms

Brain Diseases

Central Nervous System Diseases

Brain Tumor, Childhood

Ependymoma, craniopharyngioma, low-grade glioma

External Beam Radiation Therapy: 54Gy administered at 1.8Gy per day for low-grade glioma, craniopharyngioma and selected ependymoma.

Radiation Therapy

External Beam Radiation Therapy: 59.4Gy administered at 1.8Gy per day for high-grade glioma and selected ependymoma.

Thomas E. Merchant, D.O., Ph.D.

The purpose of the study was to determine if treating a limited volume of normal tissue surrounding the tumor or tumor bed using conformal radiation therapy would achieve similar rates of disease control compared to standard radiation therapy. The study was also conducted to examine the effect of irradiation on neurological, endocrine and cognitive function.

Radiation therapy is commonly used to treat a variety of brain tumors in children including ependymoma, craniopharyngioma and low- and high-grade glioma. The ability of the therapy to control brain tumors in children is known to depend on the tumor type, extent of resection and other clinical factors. Children who received radiation therapy on this study were evaluated for treatment failure at 12 months. In addition to the primary objective, the study was designed to explore the association between radiation dose and volume and a variety of neurological, endocrine and cognitive deficits up to 5 years after treatment.

A Study for Image-Guided Radiation Therapy in Pediatric Brain Tumors and Side Effects

A Phase II Study of Image-Guided Radiation Therapy for Pediatric CNS Tumors and Quantification of Radiation-Related CNS Effects

Local tumor control was determined by Magnetic Resonance Imaging (MRI) of the brain and spine performed after radiation therapy. Imaging studies were performed every 3-4 months during the first three years and then every 6 months through five years. Imaging studies demonstrating tumor progression were electronically registered to the imaging data used to plan therapy. Local failure included tumor progression within the volume that received the prescribed dose of irradiation.

St. Jude Children's Research Hospital

Patients with Ependymoma in the 1cm clinical target volume margin group.

1cm Clinical Target Volume Margin - Ependymoma

Patients with Low-grade Glioma in the 1cm clinical target volume margin group.

1cm Clinical Target Volume Margin - Low-grade Glioma

Patients with Craniopharyngioma in the 1cm clinical target volume margin group.

1cm Clinical Target Volume Margin - Craniopharyngioma

Remaining patients in the 1cm clinical target volume margin group.

1cm Clinical Target Volume Margin - Other

Patients with High-grade glioma in the 2cm clinical target volume margin group.

2cm Clinical Target Volume Margin - High-grade Glioma

Patients with Low-grade Glioma in the 2cm clinical target volume margin group.

2cm Clinical Target Volume Margin - Low-grade Glioma

Total

Age, Categorical

Sex: Female, Male

Thomas E. Merchant, DO, PhD

Patients with Ependymoma, Craniopharyngioma, Low-grade Glioma, and High-grade Glioma were analyzed by diagnosis.

Spots Global Cancer Trial Database for neoplasm intracranial