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Spots Global Cancer Trial Database for A Study for Image-Guided Radiation Therapy in Pediatric Brain Tumors and Side Effects

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Trial Identification

Brief Title: A Study for Image-Guided Radiation Therapy in Pediatric Brain Tumors and Side Effects

Official Title: A Phase II Study of Image-Guided Radiation Therapy for Pediatric CNS Tumors and Quantification of Radiation-Related CNS Effects

Study ID: NCT00187226

Study Description

Brief Summary: The purpose of the study was to determine if treating a limited volume of normal tissue surrounding the tumor or tumor bed using conformal radiation therapy would achieve similar rates of disease control compared to standard radiation therapy. The study was also conducted to examine the effect of irradiation on neurological, endocrine and cognitive function.

Detailed Description: Radiation therapy is commonly used to treat a variety of brain tumors in children including ependymoma, craniopharyngioma and low- and high-grade glioma. The ability of the therapy to control brain tumors in children is known to depend on the tumor type, extent of resection and other clinical factors. Children who received radiation therapy on this study were evaluated for treatment failure at 12 months. In addition to the primary objective, the study was designed to explore the association between radiation dose and volume and a variety of neurological, endocrine and cognitive deficits up to 5 years after treatment.

Eligibility

Minimum Age: 8 Months

Eligible Ages: CHILD, ADULT

Sex: ALL

Healthy Volunteers: No

Locations

St. Jude Children's Research Hospital, Memphis, Tennessee, United States

Contact Details

Name: Thomas E. Merchant, D.O., Ph.D.

Affiliation: St. Jude Children's Research Hospital

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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