Neoplasms

Blood and Lymph Conditions

Immune System Diseases

All Conditions

Nervous System Diseases

Symptoms and General Pathology

Rare Diseases

Lymphoma

Meningeal Carcinomatosis

Meningeal Neoplasms

Meningitis

Neuroinflammatory Diseases

Central Nervous System Neoplasms

Nervous System Neoplasms

Lymphosarcoma

Anti-Infective Agents

Antineoplastic Agents

All Drugs and Chemicals

Antirheumatic Agents

Dermatologic Agents

Reproductive Control Agents

Micronutrients

Hematinics

Vitamins

Cytarabine

Methotrexate

Antimetabolites

Enzyme Inhibitors

Folic Acid

Vitamin B Complex

Folic Acid Antagonists

Immunosuppressive Agents

Immunologic Factors

Antiviral Agents

Folinic Acid

Folate

Vitamin B9

Intrathecal (injected into the spinal fluid) DepoCyt

Intrathecal methotrexate

Intrathecal cytarabine (also known as ara-C)

Ahmet Tutuncu, MD, PhD

The purpose of this study is to find out how well an experimental drug called DepoCyt works for neoplastic meningitis (cancer that has spread to the tissues around the brain and spinal cord). DepoCyt is a new slow-release form of the cancer drug called ara-C (cytarabine). Cytarabine has been used for many years to treat cancer.

DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor

A Randomized Clinical Study to Determine the Patient Benefit and Safety of Depocyt (Cytarabine Liposome Injection) for the Treatment of Neoplastic Meningitis

Pacira Pharmaceuticals, Inc

Colonic Polyps

Polyps

Adenomatous Polyps

Pathological Conditions, Anatomical

Adenoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Herbal and Botanical

Cola

Narrow Band Imaging Colonoscope offers an alternative lightsource to view colon polyps in real time

Narrow Band Imaging

Vikas Singh, MD, MHSA

Amit Rastogi, MD

The investigators hypothesize that NBI will have a high accuracy in predicting polyp histology real time during a colonoscopy by visualization of the surface mucosal and vascular patterns. Aim#1: To determine the sensitivity, specificity and accuracy of NBI and standard white light colonoscopy for predicting polyp histology by evaluating the surface mucosal and vascular patterns during colonoscopy. Aim#2: To determine the inter-observer agreement between investigators for the recognition of various polyp patterns.

A Prospective, Single Blinded Study for Predicting Colon Polyp Histology With Narrow Band Imaging

Midwest Biomedical Research Foundation

Principal Investagator

Topotecan

Topoisomerase I Inhibitors

Induction (4 weeks): Patients will receive IT topotecan for 5 consecutive days during weeks 1 and 3.

The Induction period is the first 4 weeks of therapy.

Consolidation (6 weeks): Patients will receive IT topotecan for 5 consecutive days during weeks 1 and 4. The Consolidation period is 6 weeks in duration. Consolidation begins immediately after completion of the 4th week of Induction.

Maintenance (4 weeks for 11 courses): Patients will receive IT topotecan for 5 consecutive days during week 1. Each course of Maintenance is 4 weeks in duration. Maintenance begins immediately after completion of the 6th week of Consolidation.

Susan Blaney, MD

1. To find the optimal dose of topotecan that can safely be given directly into the spinal fluid (called intrathecal administration) of children whose cancer has spread to the lining of the brain and/or spinal cord.
2. To find out what effects (good and bad) topotecan has when given directly into the cerebrospinal fluid in children with neoplastic meningitis (cancer that has spread to the lining of the brain and spinal cord).

   * Cerebrospinal fluid is the fluid that circulates around the brain and spinal cord.
3. To determine if intrathecal topotecan is beneficial to patients.
4. To better understand how topotecan is handled by the body after intrathecal administration.
5. To evaluate the cerebrospinal fluid for signs (markers) of tumor spread.

This is a multi-center, non-randomized pharmacokinetically-guided optimal dosing study of intraventricular topotecan in children with neoplastic meningitis. Topotecan will be administered daily for five consecutive days utilizing the schema shown in the Schema below. Concomitant chemotherapy to control systemic disease or bulk CNS disease is allowable provided that the systemic chemotherapy is not an investigational agent or one of the following: high-dose methotrexate (\> 1g/m2), high-dose cytarabine (\> 1g/m2), 5-fluorouracil, capecitabine, thiotepa, a nitrosourea, or topotecan. The starting dose for this trial was derived from pharmacokinetic simulations that utilized data from a prior phase I study of intrathecal topotecan. The simulations were performed to estimate the length of time that ventricular CSF concentrations of topotecan lactone would remain above an optimal "target level" of 1 ng/mL. One of the primary objectives of this study is to estimate the dose of intrathecal topotecan that will result in CSF lactone concentrations exceeding 1 ng/mL for at least eight hours after an intrathecal injection. Dose escalations for patient cohorts will be conducted following the traditional phase 1 design in order to determine the maximum tolerated dose (MTD). The MTD will be called pharmacokinetically optimal if that dose achieves the targeted PK parameter in at least 23 of 25 patients treated at that dose level.

Phase 1 Intrathecal Topotecan for Neoplastic Meningitis

A Phase I Pharmacokinetic Optimal Dosing Study of Intrathecal Topotecan for Children With Neoplastic Meningitis

GlaxoSmithKline

Baylor College of Medicine

Professor of Pediatrics

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor	NCT00029523	Meningeal Neopl...	Intrathecal (in... Intrathecal met... Intrathecal cyt...	18 Years -	Pacira Pharmaceuticals, Inc
A Prospective, Single Blinded Study for Predicting Colon Polyp Histology With Narrow Band Imaging	NCT00613262	Colonoscopy Adenomatous Pol... Neoplastic	Narrow Band Ima...	18 Years -	Midwest Veterans' Biomedical Research Foundation
Phase 1 Intrathecal Topotecan for Neoplastic Meningitis	NCT00674674	Neoplastic Meni...	Topotecan Topotecan Topotecan	3 Years - 21 Years	Baylor College of Medicine

Spots Global Cancer Trial Database for neoplastic

Every month we try and update this database with for neoplastic cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for neoplastic

Every month we try and update this database with for neoplastic cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for neoplastic cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.