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Brief Title: DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor
Official Title: A Randomized Clinical Study to Determine the Patient Benefit and Safety of Depocyt (Cytarabine Liposome Injection) for the Treatment of Neoplastic Meningitis
Study ID: NCT00029523
Brief Summary: The purpose of this study is to find out how well an experimental drug called DepoCyt works for neoplastic meningitis (cancer that has spread to the tissues around the brain and spinal cord). DepoCyt is a new slow-release form of the cancer drug called ara-C (cytarabine). Cytarabine has been used for many years to treat cancer.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Barrow Neurological Institute, Phoenix, Arizona, United States
Alta Bates Comprehensive Cancer Center, Berkeley, California, United States
University of Southern California, Norris Cancer Center, Los Angeles, California, United States
University of Colorado Hospital, Anschutz Cancer Pavilion, Denver, Colorado, United States
Georgetown University Medical Center Hematology/Oncology, Washington, District of Columbia, United States
Mayo Clinic, Jacksonville, Jacksonville, Florida, United States
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States
Emory Clinic, Department of Neurosurgery, Atlanta, Georgia, United States
Straub Clinic and Hospital, Honolulu, Hawaii, United States
Rush Cancer Institute, Chicago, Illinois, United States
Loyola University Medical Center, Dept. of Hematology/Oncology, Maywood, Illinois, United States
Beth Israel Deaconess Medical Center Dept. of Neurology, Boston, Massachusetts, United States
Park Nicollet Institute, Oncology Research Program, Minneapolis, Minnesota, United States
JFK Neuroscience Institute, Edison, New Jersey, United States
Bowman Gray School of Medicine/Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina, United States
Case Western Reserve University Hospital of Cleveland, Cleveland, Ohio, United States
University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States
Vanderbilt University Medical Center, Nashville, Tennessee, United States
University of Texas Health Science Center, San Antonio, Texas, United States
University of Utah, Hunsman Cancer Institute, Salt lake City, Utah, United States
Virginia Mason Medical Center, Seattle, Washington, United States
CancerCare Manitoba, Winnipeg, Manitoba, Canada
Toronto Sunnybrook Regional Cancer Center, Toronto, Ontario, Canada
Name: Ahmet Tutuncu, MD, PhD
Affiliation: Pacira Pharmaceuticals, Inc
Role: STUDY_DIRECTOR