Neoplasms

All Conditions

Skin and Connective Tissue Diseases

Behaviors and Mental Disorders

Substance Related Disorders

Carcinoma

Breast Neoplasms

Cognitive Dysfunction

Chemotherapy-Related Cognitive Impairment

Breast Diseases

Skin Diseases

Patient enrolled in a cognitive rehabilitation program using Neurotablet® and paper and pencil exercises

Patient NOT enrolled in a cognitive rehabilitation program using Neurotablet® and paper and pencil exercises.

The experimental group will carry out cognitive rehabilitation using the Neurotablet device. The cognitive rehabilitation will be performed for 10 consecutive weeks, once a week for 1 hour. Neuropsychological evaluations will be conducted before the start of chemotherapy (T0), 6 months (T1) and 12 months (T2) after the start of chemotherapy. Neuropsychological evaluations will include tests to analyze the main cognitive domains of memory, attention, executive functions and learning.

Neurotablet® and Neuropsychological evaluations

Neuropsychological evaluations will be conducted before the start of chemotherapy (T0), 6 months (T1) and 12 months (T2) after the start of chemotherapy. Neuropsychological evaluations will include tests to analyze the main cognitive domains of memory, attention, executive functions and learning.

Neuropsychological evaluations

Ornella Garrone, MD

An interventional, non-pharmacological, monocentric study evaluating the effectiveness of cognitive rehabilitation in counteracting chemotherapy-induced cognitive impairment (CRCI) in women with operable breast cancer treated with neo-adjuvant therapy and/ or adjuvant therapy.

This interventional, non-pharmacological, monocentric study examines the effectiveness of cognitive rehabilitation in counteracting CRCI in women with operable breast cancer treated with neo-adjuvant therapy and/ or adjuvant therapy.

A total of 128 patients will be randomized 1:1 into two groups:

* Experimental group, which will participate in a cognitive rehabilitation program using Neurotablet® and paper and pencil exercises. To evaluate the efficacy of the cognitive rehabilitation program, neurocognitive evaluations will be performed.
* Control group, which will only carry out neuropsychological assessments.

Neuropsychological evaluations will be conducted before the start of chemotherapy (T0), 6 months (T1) and 12 months (T2) after the start of chemotherapy. Neuropsychological evaluations will include tests to analyze the main cognitive domains of memory, attention, executive functions and learning.

CHEmotherapy and Cognitive Deterioration in Patients With Operable Breast Cancer: Impact of Cognitive Rehabilitation (CHEMOFOG)

CHEMioterapia e Deterioramento cOgnitivo Nelle Pazienti aFfette da Carcinoma Mammario

Test the effectiveness of a 10-week cognitive rehabilitation program in limiting or preventing chemotherapy-induced cognitive impairment. To test the efficacy of this cognitive rehabilitation program, neurocognitive evaluations will be performed.

Analysis of cognitive function trends though neurocognitive evaluations

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Nervous System Diseases

Symptoms and General Pathology

Diseases and Abnormalities at or Before Birth

Rare Diseases

Cognition Disorders

Dyslexia

Neurofibromatoses

Neurofibromatosis 1

Neurofibroma

Nerve Sheath Neoplasms

Neoplasms, Nerve Tissue

Neoplasms by Histologic Type

Syndrome

Neoplastic Syndromes, Hereditary

Neurocutaneous Syndromes

Heredodegenerative Disorders, Nervous System

Neurodegenerative Diseases

Genetic Diseases, Inborn

Peripheral Nervous System Diseases

Neuromuscular Diseases

Nervous System Neoplasms

Peripheral Nervous System Neoplasms

Language Disorders

Communication Disorders

Neurobehavioral Manifestations

Neurologic Manifestations

Learning Disabilities

Specific Learning Disorder

Neurodevelopmental Disorders

Mental Disorders

Psychotic Disorders

Neurofibromatosis

Neurofibromatosis Type 1

Children diagnosed with NF1 according the NIH criteria Neuropsychological assessments

Control group children without NF1 with the same reading level Neuropsychological assessments

Neuropsychological assessments:

Intelligence Quotient (WISC-IV)

Reading tests (reading accuracy, reading speed, reading comprehension and strategy):

Alouette test, Lobrot test, Odedys test. Visio-spatial skill (JLO, Thurston, Corsi tests) Attention (CPT 2, CBCL) Receptive oral language (EVIP)

Neuropsychological assessments

Yves CHAIX, Professor

A national, multicenter, randomized, transverse clinical trial, estimating the existence of phonological deficits in children with NF1 children compared with control children without NF1 with the same reading level.

To determine the phonological and visio -spatial performances at the NF1 children.

Reading Disability in Children With NF1

Neuropsychological Characterisation of Cognitive Deficits Involved in Reading Disability in Children With NF1

Evaluate whether there is a specificity of phonological deficits in children with NF1 compared with a population of children with the same age and same reading level, taking into account the intellectual level.

Studying the correlations between phonological deficits and visio-spatial and literacy skills.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
CHEmotherapy and Cognitive Deterioration in Patients With Operable Breast Cancer: Impact of Cognitive Rehabilitation (CHEMOFOG)	NCT06435559	Breast Cancer	Neurotablet® an... Neuropsychologi...	18 Years - 75 Years	Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
CHEmotherapy and Cognitive Deterioration in Patients With Operable Breast Cancer: Impact of Cognitive Rehabilitation (CHEMOFOG)	NCT06435559	Breast Cancer	Neurotablet® an... Neuropsychologi...	18 Years - 75 Years	Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Reading Disability in Children With NF1	NCT02397967	Neurofibromatos...	Neuropsychologi...	8 Years - 12 Years	University Hospital, Toulouse
CHEmotherapy and Cognitive Deterioration in Patients With Operable Breast Cancer: Impact of Cognitive Rehabilitation (CHEMOFOG)	NCT06435559	Breast Cancer	Neurotablet® an... Neuropsychologi...	18 Years - 75 Years	Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Reading Disability in Children With NF1	NCT02397967	Neurofibromatos...	Neuropsychologi...	8 Years - 12 Years	University Hospital, Toulouse

Spots Global Cancer Trial Database for neuropsychological assessments