Nutritional and Metabolic Diseases

Symptoms and General Pathology

All Conditions

Mouth and Tooth Diseases

Rare Diseases

Obesity

Periodontitis

Necrosis

Chronic Periodontitis

Periodontal Diseases

Mouth Diseases

Stomatognathic Diseases

Chronic Disease

Disease Attributes

Chronic Graft Versus Host Disease

Central Nervous System Depressants

All Drugs and Chemicals

Anesthetics

GCF samples were taken at baseline Intervention: Gingival crevicular fluid collection

GCF samples were taken before and after treatment chronic periodontitis patients.

Intervention: Non- surgical periodontal treatment (SRP and oral hygiene instructions)

1. SRP under local anaesthesia, in a total of 2-3 clinical visits.
2. Oral hygiene instructions including the modified Bass technique, regular toothpaste, and an appropriate interdental cleaning device with dental floss and interdental brush.

non surgical periodontal treatment

GCF collection with filter paper (Periopaper) using the intracrevicular method.

Gingival crevicular fluid collection

Our objective in this case-control intervention study, therefore, was to explore the effect of nonsurgical periodontal therapy on the GCF levels of vaspin and omentin in patients with chronic periodontitis in order to determine the usefulness of vaspin and omentin as a diagnostic and prognostic biomarker of periodontal disease.

All individuals underwent a full-mouth periodontal examination, which included probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), gingival index (GI), bleeding on probing (BOP). BMI and WHR were used for assessing obesity. In addition, HbA1c and fasting plasma glucose levels were used for elimination of diabetes mellitus. Based on the periodontal and anthropometric measurements, individuals (n=76) were divided into four groups: the periodontal-healthy group (n=19), chronic periodontitis group (n=19), periodontal-healthy with obesity group (n=19) and chronic periodontitis with obesity group (n=19). Periodontitis patients received nonsurgical periodontal therapy. GCF sampling and clinical periodontal parameters were assessed before and 6 weeks after therapy. Vaspin, omentin, and TNF-α levels were measured by enzyme-linked immunosorbent assay.

Gingival Crevicular Fluid Vaspin and Omentin Levels in Obese Patients With Chronic Periodontitis

Effects of Non-Surgical Periodontal Treatment on the Gingival Crevicular Fluid Levels of Vaspin and Omentin-1 in Obese Patients With Chronic Periodontitis

The changes in levels of vaspin and omentin 6 weeks after periodontal treatment determined by ELISA. The changes in levels of vaspin and omentin were analyzed to determine diagnostic and prognostic potential as a biomarker of periodontal disease.

The changes in levels of tumor necrosis factor alfa 6 weeks after periodontal treatment determined by ELISA.

The changes in probing pocket depth after periodontal treatment.Probing pocket depth was measured for determining severity of disease and clinic outcome.

The changes in clinical attachment level after periodontal treatment. Clinical attachment level was measured for determining severity of disease and clinic outcome.

The changes in gingival index after periodontal treatment. Gingival index was recorded for classifying and evaluating (coronally) gingival inflammation. Also, gingival index was also analyzed to detect the relationship between vaspin, omentin and tumor necrosis factor alfa.

The changes in plaque index after periodontal treatment. Plaque index was recorded for determining and classifying oral hygiene status.

The changes in bleeding on probing after periodontal treatment. Bleeding on probing was recorded for classifying and evaluating (apically) gingival inflammation.

Umut BALLI

Bulent Ecevit University

Neoplasms

Skin and Connective Tissue Diseases

Breast Neoplasms

Mammary Neoplasms, Animal

Breast Diseases

Skin Diseases

The NSPT, which consisted of subgingival debridement - scaling and root planning (SRP) under local anesthesia.

The NSPT, which consisted of subgingival debridement - scaling and root planning (SRP) under local anesthesia. On average, the treatment of the entire oral cavity was completed within four sessions (sessions of 50 minutes). The SRP was performed by one experienced periodontist (KRVV) using Gracey curettes (Hu-Friedy MFG. Co. Inc., Chicago, IL, USA), ultra-sonic devices (Bob-Cat, Dentsply/Cavitron, Long Island City, NY, USA) and, if necessary, with multilaminated drills.

Non surgical periodontal Treatment

Aim: This study evaluated the effects of non-surgical periodontal therapy (NSPT) on the cytokine profile and the correlation to clinical parameters of patients undergoing chemotherapy for breast cancer.

Materials and methods: 40 patients were allocated: periodontitis patients (P) (n=20) and breast cancer with periodontitis patients (CAN/P) (n=20). The clinical parameters: probing depth (PD), clinical attachment level (CAL), plaque index (PI), Bleeding on probing (BOP) and levels of IFN-γ, IL-4, IL-10, TGF-β, IL-17, IL-2, IL-6, IL-1β and TNF-α in gingival crevicular fluid (GCF) were evaluated at baseline, 45 and 180 days after therapy.

40 patients were allocated: periodontitis patients (P) (n=20) and breast cancer with periodontitis patients (CAN/P) (n=20). The clinical parameters: probing depth (PD), clinical attachment level (CAL), plaque index (PI), Bleeding of probing (BOP) and levels of IFN-γ, IL-4, IL-10, TGF-β, IL-17, IL-2, IL-6, IL-1β and TNF-α in gingival crevicular fluid (GCF) were evaluated at baseline, 45 and 180 days after therapy.

Women with cancer and without breast cancer between 35 and 70 years of age

Cytokine Profiles in Breast Cancer Patients Undergoing Chemotherapy

Effects of Non-surgical Periodontal Treatment on the Gingival Crevicular Fluid Cytokine Profiles in Breast Cancer Patients Undergoing Chemotherapy

De- identified individual participant for all primary and secundary outcome measures will be made available

Cytokine levels and changes before and after post treatment

cytokine levels between parameters clinical

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Gingival Crevicular Fluid Vaspin and Omentin Levels in Obese Patients With Chronic Periodontitis	NCT02563171	Obesity Periodontitis	non surgical pe... Gingival crevic...	30 Years - 49 Years	Bulent Ecevit University
Cytokine Profiles in Breast Cancer Patients Undergoing Chemotherapy	NCT03244943	Mammary Neoplas... Periodontal Dis... Chemotherapy Ef...	Non surgical pe...	35 Years - 70 Years	University of Sao Paulo

Spots Global Cancer Trial Database for non surgical periodontal treatment