Symptoms and General Pathology

All Conditions

Neoplasms

Nervous System Diseases

Musculoskeletal Diseases

Rare Diseases

Pain, Postoperative

Pain

Spinal Cord Neoplasms

Spinal Neoplasms

Postoperative Complications

Neurologic Manifestations

Central Nervous System Neoplasms

Nervous System Neoplasms

Spinal Cord Diseases

Central Nervous System Diseases

Bone Neoplasms

Bone Diseases

Spinal Diseases

Acute Graft Versus Host Disease

Central Nervous System Depressants

All Drugs and Chemicals

Psychotropic Drugs

Analgesics

Channel Blockers

Anticonvulsants

Bone Density Conservation Agents

Anesthetics

Esketamine

Ketamine

Pregabalin

Anesthetics, Dissociative

Anesthetics, Intravenous

Anesthetics, General

Excitatory Amino Acid Antagonists

Neurotransmitter Agents

Calcium

Calcium Channel Blockers

Calcium, Dietary

Hormones

Anti-Anxiety Agents

Antidepressive Agents

* Drug: Pregabalin
* 150mg (2hrs) pre operatively and 75mg twice daily post operatively for 7 days(POD1-7), followed by dose reduction to 75mg once daily for 7 days(POD8-14)
* Drug: S-ketamine infusion
* 0.5 mg/kg bolus after induction of anesthesia +0.12 mg/kg/h continuous intravenous infusion for 48 h

S-ketamine and pregabalin

* Drug: Placebo capsules
* Two placebo capsules (2hrs) preoperatively and twice daily post operatively for 7days, followed by dose reduction to single capsule once daily for 7days
* Drug: Normal saline
* 0.9% saline bolus after induction of anesthesia + intravenous infusion for 48 hours

Normal saline and placebo capsule

Ruquan Han, M.D., Ph D.

Postsurgical pain is now known to be one of the most common and difficult-to-treat complications of surgery. severe postoperative pain can significantly impair patients' quality of life, social functioning and contribute to excessive health care expenditures. It is worth noting that acute postoperative pain may play a vital role in central sensitization and up-regulation of pain receptors, even factors implicated in the development of CPSP. According to previous studies, the incidence of postoperative pain among patients undergoing spinal surgery was nearly 80%. At the same time, perioperative pain management of patients undergoing spinal surgery has not been clearly. For the past few years, pregabalin and esketamine are becoming important roles in perioperative pain management, lots of studies have shown that these two analgesics might relieve postoperative pain. The aim of this study was to evaluate the acute analgesic effects of esketamine and pregabalin in combination after spinal cord neoplasms resection, so as to find a better way to help the patients undergoing spinal surgery keep away from the acute perioperative pain.

Esketamine Combined With Pregabalin on Acute Postoperative Pain in Patients Undergoing Resection of Spinal Neoplasms.

The primary outcome was the proportion of patients with acute moderate-to-severe postsurgical pain during the 48-h postoperative period (defined as a VAS score ≥ 40 mm).

Beijing Tiantan Hospital

Professor

Chronic Graft Versus Host Disease

Ruquan Han, M.D., Ph D

Chronic postsurgical pain has become one of the most common complications of surgery. The quality of life will be impacted once the postsurgical patients are combined with persistent pain. What's more, the postsurgical pain may increase other adverse outcomes. It's important to find a better way to keep the postsurgical patients away from postoperative pain. Esketamine and pregabalin have become potentially effective drugs on CPSP.

Esketamine Combined With Pregabalin on CPSP in Spinal Patients.

Esketamine Combined With Pregabalin on Chronic Postsurgical Pain in Patients Undergoing Primary Spinal Tumor Surgery.

The primary outcome was the proportion of patients with CPSP during the 3-month postoperative period (defined as a NRS score ≥ 3).

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Esketamine Combined With Pregabalin on Acute Postoperative Pain in Patients Undergoing Resection of Spinal Neoplasms.	NCT05096468	Esketamine Pregabalin Acute Postopera... Neurosurgical P... Perioperative C... Spinal Cord Neo...	S-ketamine and ... Normal saline a...	18 Years - 65 Years	Beijing Tiantan Hospital
Esketamine Combined With Pregabalin on CPSP in Spinal Patients.	NCT06117917	Esketamine Pregabaline Chronic Post Op...	S-ketamine and ... Normal saline a...	18 Years - 65 Years	Beijing Tiantan Hospital
Esketamine Combined With Pregabalin on CPSP in Spinal Patients.	NCT06117917	Esketamine Pregabaline Chronic Post Op...	S-ketamine and ... Normal saline a...	18 Years - 65 Years	Beijing Tiantan Hospital

Spots Global Cancer Trial Database for normal saline and placebo capsule