Symptoms and General Pathology

All Conditions

Neoplasms

Nervous System Diseases

Musculoskeletal Diseases

Rare Diseases

Pain, Postoperative

Pain

Spinal Cord Neoplasms

Spinal Neoplasms

Postoperative Complications

Neurologic Manifestations

Chronic Graft Versus Host Disease

Central Nervous System Depressants

All Drugs and Chemicals

Psychotropic Drugs

Analgesics

Channel Blockers

Anticonvulsants

Bone Density Conservation Agents

Anesthetics

Esketamine

Ketamine

Pregabalin

Anesthetics, Dissociative

Anesthetics, Intravenous

Anesthetics, General

Excitatory Amino Acid Antagonists

Neurotransmitter Agents

Calcium

Calcium Channel Blockers

Calcium, Dietary

Hormones

Anti-Anxiety Agents

Antidepressive Agents

* Drug: Pregabalin
* 150mg (2hrs) pre operatively and 75mg twice daily post operatively for 7 days(POD1-7), followed by dose reduction to 75mg once daily for 7 days(POD8-14)
* Drug: S-ketamine infusion
* 0.5 mg/kg bolus after induction of anesthesia +0.12 mg/kg/h continuous intravenous infusion for 48 h

S-ketamine and pregabalin

* Drug: Placebo capsules
* Two placebo capsules (2hrs) preoperatively and twice daily post operatively for 7days, followed by dose reduction to single capsule once daily for 7days
* Drug: Normal saline
* 0.9% saline bolus after induction of anesthesia + intravenous infusion for 48 hours

Normal saline and placebo capsule

Ruquan Han, M.D., Ph D

Ruquan Han, M.D., Ph D.

Chronic postsurgical pain has become one of the most common complications of surgery. The quality of life will be impacted once the postsurgical patients are combined with persistent pain. What's more, the postsurgical pain may increase other adverse outcomes. It's important to find a better way to keep the postsurgical patients away from postoperative pain. Esketamine and pregabalin have become potentially effective drugs on CPSP.

Esketamine Combined With Pregabalin on CPSP in Spinal Patients.

Esketamine Combined With Pregabalin on Chronic Postsurgical Pain in Patients Undergoing Primary Spinal Tumor Surgery.

The primary outcome was the proportion of patients with CPSP during the 3-month postoperative period (defined as a NRS score ≥ 3).

Beijing Tiantan Hospital

Professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Esketamine Combined With Pregabalin on CPSP in Spinal Patients.	NCT06117917	Esketamine Pregabaline Chronic Post Op...	S-ketamine and ... Normal saline a...	18 Years - 65 Years	Beijing Tiantan Hospital
Esketamine Combined With Pregabalin on CPSP in Spinal Patients.	NCT06117917	Esketamine Pregabaline Chronic Post Op...	S-ketamine and ... Normal saline a...	18 Years - 65 Years	Beijing Tiantan Hospital

Spots Global Cancer Trial Database for pregabaline

Every month we try and update this database with for pregabaline cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for pregabaline

Every month we try and update this database with for pregabaline cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for pregabaline cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.