Neoplasms

Digestive System Diseases

All Conditions

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Anti-Arrhythmia Agents

Channel Blockers

Central Nervous System Depressants

All Drugs and Chemicals

Lidocaine

Anesthetics

Anesthetics, Local

Sodium Channel Blockers

Diuretics, Potassium Sparing

Patients undergoing laparoscopic surgery for resection of colorectal cancer will benefit of an infusion of intravenous lidocaine from the induction of anesthesia untill one hour after PACU admission

Infusion of normal saline form the induction of anaesthesia untill one hour after PACU admission

Lidocaine infusion: 1.5 mg/kg bolus on 10 minutes (maximum 150 mg) followed by 1.5 mg/kg/h

Intravenous Lidocaine

Normal saline infusion: 1.5 mg/kg bolus on 10 minutes (maximum 150 mg) followed by 1.5 mg/kg/h

Normal saline infusion

louis-Philippe Fortier, M.D.

Nadia godin

Louis-Philippe Fortier, M.D.

Surgical resection is the best treatment option for colorectal cancer. Despite this radical approach, recurrences within five years are still common. Several authors have proposed that the immunosuppressive state surrounding the perioperative period was a key element of cancer cells spread.

A particular subtype of T lymphocytes, the Natural Killer cells (NKs), is the main actor of the innate immune system. Several factors of the perioperative period can reduce activity of NKs such as stress, pain, opioids and general anaesthetics.

Lidocaine is a local anaesthetic that has been widely used intravenously for abdominal surgeries. Intravenous lidocaine has been shown to reduce pain scores, morphine consumption, ileus time and length of stay in major colorectal surgeries. It reduced markers of systemic inflammation as well.

The authors hypothesize that the use of intravenous lidocaine during laparoscopic surgeries for colorectal cancer resection will preserve NKs activity.

NK Activity Modulation Induced by Intravenous Lidocaine During Colorectal Laparoscopic Surgery

NK Activity Modulation by Intravenous Lidocaine During Laparoscopic Colorectal Surgery

From the PACU to the 3rd day after surgery

Morphine consumption from the PACU to the 3rd day after surgery

Cumulative dose of fentanyl needed for the surgery

Nausea and vomiting from the PACU to the 3rd day after surgery

Hypotension, heart rythm blocks, tachycarida, bradycardia

Maisonneuve-Rosemont Hospital

Principal investigator

Respiratory Tract (Lung and Bronchial) Diseases

Symptoms and General Pathology

Rare Diseases

Lung Neoplasms

Pain, Postoperative

Pain

Chronic Graft Versus Host Disease

Intravenous normal saline infusion - control group

In group L, intravenous lidocaine infusion(0.1mg/kg) for 10minutes after induction of anesthesia. After 10 minutes, lidocaine infusion continued at rate of 3mg/kg/hr during operation, and discontinued before move the patients to PACU.

Systemic intravenous lidocaine infusion

In group C, the patients receive same volume of normal saline

Systemic lidocaine infusion may improve the patients' chronic post surgical pain after video-assisted thoracic surgery

The Impact of Intraoperative Systemic Lidocaine Infusion on Chronic Postoperative Pain After Video-assisted Thoracic Surgery (VATS)

Assessing pain score by Short-form McGill pain questionnaire at 2 months after operation

Yonsei University

Gland and Hormone Related Diseases

Thyroid Neoplasms

Thyroid Diseases

Endocrine System Diseases

Endocrine Gland Neoplasms

Head and Neck Neoplasms

normal saline infusion

Systemic lidocaine infusion may improve the patients' recovery quality and chronic post surgical pain after robot-assisted thyroidectomy

Effects of Systemic Lidocaine on Postoperative Quality of Recovery After Robot-assisted Thyroidectomy

Assessing change of the Quality of recovery 40(QoR-40) score between 24hours before and after operation

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
NK Activity Modulation Induced by Intravenous Lidocaine During Colorectal Laparoscopic Surgery	NCT01841294	Colorectal Canc...	Intravenous Lid... Normal saline i...	18 Years - 80 Years	Maisonneuve-Rosemont Hospital
The Impact of Intraoperative Systemic Lidocaine Infusion on Chronic Postoperative Pain After Video-assisted Thoracic Surgery (VATS)	NCT02006966	Lung Cancer(Pri... Benign Lung Mas...	Systemic intrav... Normal saline i...	20 Years - 65 Years	Yonsei University
NK Activity Modulation Induced by Intravenous Lidocaine During Colorectal Laparoscopic Surgery	NCT01841294	Colorectal Canc...	Intravenous Lid... Normal saline i...	18 Years - 80 Years	Maisonneuve-Rosemont Hospital
Effects of Systemic Lidocaine on Postoperative Quality of Recovery After Robot-assisted Thyroidectomy	NCT01907997	Thyroid Cancer	Systemic intrav... normal saline i...	20 Years - 65 Years	Yonsei University

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