Symptoms and General Pathology

All Conditions

Mouth and Tooth Diseases

Digestive System Diseases

Ulcer

Stomatitis

Mucositis

Gastroenteritis

Gastrointestinal Diseases

Mouth Diseases

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Anti-Infective Agents

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All Drugs and Chemicals

Micronutrients

Vitamins

Levofloxacin

Ofloxacin

Tocopherols

Vitamin E

Tocotrienols

alpha-Tocopherol

Voriconazole

Antioxidants

Trace Elements

Protective Agents

Tocopherol

Tocotrienol

Vitamin E is an antioxidant agent which may limit tissue damage from free oxygen radicals and, thus, may reduce the severity of mucositis during cancer treatments and protect cell membranes from radiation damage (Alterio et al., 2007). It has a very low toxicity and is generally well-tolerated (Geeraert et al., 2015).

oral topical vitamin E

Statement of problem Oral mucositis is an inflammatory condition that affects mucosa of the oral cavity. The etiology of this kind of aggravation is related to the introduction of radiotherapy or chemotherapeutic medications. (Alvarino et al., 2014, Rohani et al., 2015) With the prevalence of mucositis up to 80% in pediatric patient (Cheng et al., 2004).

Clinically, oral mucositis is a painful situation that significantly affects patients' quality of life. The severe cases are associated with ulcerated mucosa and secondary infection which may led to life-threatening sepsis. (Kolokythas , et al., 2010) Oral mucositis is one of the most debilitating complications following chemotherapy, its remains an unresolved clinical problem, and it has physical and psychosocial implications for patients. The ulcerative lesions are often very painful, requiring treatment with analgesics and supportive nutrition, and the cancer treatment may need to be interrupted or modified. All these conditions may increase treatment costs, preclude further treatment and alter the quality of life of the patient. (Sonis et al., 2001) There are many oral care regimens including prophylactic antibacterial and antifungal drugs, Levofloxacin is antibacterial drug causing inhibition of cell wall synthesis agent, Levofloxacin failed to show any significant difference in mucositis or oral ulceration (Bucaneve et al., 2005). While voriconazole is antifungal that has been noted to cause transient visual disturbances and A major drawback is potential interactions with certain chemotherapy agents (Marks et al., 2011).

Vitamin E is an antioxidant agent which may limit tissue damage from free oxygen radicals and, thus, may reduce the severity of mucositis during cancer treatments and protect cell membranes from radiation damage (Alterio et al., 2007). It has a very low toxicity and is generally well-tolerated (Geeraert et al., 2015).

Rationale

There is no enough studies about vitamin E effect in reduction of oral mucositis.

El -Housseiny et al., (2007), recommend that oral mucositis is successfully treated by the topical application of vitamin "E", compared to its systemic administration. Vitamin "E" alone is not enough for the treatment of infected lesions; further studies using vitamin "E" to treat the infected lesions are needed.

Also based on the recommendation of Wadleigh et al., (1992) who was the first one to study the topical effect of vitamin "E" on oral mucositis; however, they did not know whether the effect was due to the topical application or the systemic absorption of the vitamin when applied topically.

Benefit to patient and population:

The vitamin E is nontoxic, odorless, tasteless, and well tolerated by the patients, reduce nutritional compromise, maintain impact on quality of life, and reasonable economic costs.

Benefits of practitioners and clinicians:

The use of vitamin E is easy to apply, not technique sensitive and it is cheap and readily available reducing clinical time.

Title Prevention of oral mucositis after using oral topical vitamin E versus voriconazole and levofloxacin in pediatric cancer patients receiving chemotherapy.

Title registration:

The study is to be registered on ClinicalTrials.gov/

Protocol version:

Version (1)

Funding:

Self-funding Roles and responsibilities

Principle investigator:

Samah omer Mekki B.D.S, Faculty of Dentistry, Khartoum College of Medical Sciences, Sudan (2011) Will make case selection, methodology, instructions and patient recall. Then write the thesis and perform a master table for the results.

Main supervisor: Prof.Dr. Mahmoud Hamdy.

* Professor of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Cairo University.
* Prof.Dr. Mahmoud Hamdy will supervise all procedures and sort out any foreseen or existing problem. He will initially consult with a statistician for developing the study design, statistical analysis, results presentation design and interpretation.

Assistant supervisor: Dr. Nada Wassef.

* Lecturer of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Cairo University.
* The assistant supervisor will supervise clinical steps and findings revise and edit the draft of thesis.

Assistant supervisor: Dr. Asmaa Mohammed Hamoda

* Lecturer of Pediatric oncology, National cancer institute, Cairo university.
* Will validate diagnosis of selected cases to ensure that only indicated case are included in the study, clinical evaluation of post intervention findings and follow up. Revise, edit the first draft of thesis.

Trial sponsor:

Department of Pediatric oncology, National Cancer Institute, Cairo university.

Role of study sponsor:

Provide access to children receiving Chemotherapy.

Committees:

National Cancer Institute Committees:

1- Research Plan committee. 2- Department Board committee. 3-Ethics Committee. 4-Institute Board.

Department of Pediatric Dentistry, Faculty of Dentistry- Cairo University:

1. Department Board.
2. Research Plane Committee.
3. Evidence Based Committee, Faculty of Dentistry - Cairo University.
4. Ethics Committee, Faculty of Dentistry - Cairo University.
5. Higher Education and Research Committee.
6. Faculty Board.

   Research question:

   Is topical oral vitamin E application more effective in prevention of oral mucositis in pediatric cancer patients receiving chemotherapy compared to Voriconazole and Levofloxacin as standard protocol? Choice of comparators Aim of The Study The aim of the present study is to assess the prevention of oral mucositis after using oral topical vitamin E versus voriconazole and levofloxacin in pediatric cancer patients receiving chemotherapy.

   Hypothesis Objectives of The Study

   • Primary objective: To evaluate the Effectiveness of Vitamin E versus Voriconazole and Levofloxacin in prevention of chemotherapy induced oral mucositis in pediatric cancer patients.

   • Secondary objective: To evaluate the role of Vitamin E in prevention of chemotherapy induced oral mucositis in pediatric patients with cancer.

   Trial design:

   - A Randomized clinical trial.

   PICOS (P) Population: Children with cancer receiving chemotherapy. (I) Intervention: Topical vitamin "E" application. (C) Control: Voriconazole and Levofloxacin application. (O) Outcome: Outcome measure Outcome measuring Outcome measuring unit

   Primary outcome:

   Patient reported mucositis Children's International Mucositis Evaluation Scale (ChIMES). (Jacobs et al., 2013) (Appendix A)

   Score (0-5)

   Secondary outcome:

   Clinical assessment of mucositis Oral mucositis WHO Toxicity System (Dos Reis et al., 2016) (Appendix B) Score (0-4)

   - Study (S): A Randomized clinical trial.

   Search strategy:

   - Keywords: -. Vitamin E, Chemotherapy, Oral Mucositis, Voriconazole, Levofloxacin Children and Cancer.
   * Date of search: 01\\3\\2018
   * Following databases were searched:

     \*PubMed database. \*Hand searching (Google scholars).

     \* The Cochrane Library.

     • The search was limited to English articles only. Electronic and manual searches were performed
     * Inclusion criteria for Articles:

       a. Articles written in English language only. b. Articles including oral mucositis. c. Randomized clinical trials, systematic reviews and meta-analysis.
     * Exclusion criteria for Articles:

       1. Articles including other Vitamin than Vitamin E.
       2. Articles with treatment approaches.

   Methods

   Study setting:
   * The study will be conducted in Department of Pediatric Oncology, National Cancer Institute.
   * Data for this particular study will be collected at Pediatric Department, National Cancer Institute.

   Participants:

   Eligibility criteria:

   Inclusion criteria:

   All children fulfilling the following criteria will be included:



1. Patients with healthy and intact oral mucosa.
2. Patients diagnosed with Acute Myeloid leukemias for the first time or during consolidation cycle.
3. Both male and female patients undergoing chemotherapy at in and Out patient units of Pediatric Oncology department.
4. Age of patient ranging (6- 18) years old.
5. Legal representatives of patient must be able to read, understand and provide informed consent to participate in the trial.
6. Patients with no history of dental discomfort related to cold or hot food or beverage intake.
7. Patients receiving chemotherapeutic regimen known to cause oral mucositis (e.g. Cytarabine and Etoposide).

Exclusion criteria:

Exclusion criteria included the presence of any of the following:

1. Administration of antiviral or antifungal therapy and/or any other treatment for oral mucositis before enrollment in the study.
2. Presence of advanced or severe periodontitis (pocket depth more than 6mm).
3. Patients who are scheduled for radiotherapy as part of their treatment. Intervention

Diagnosis:

1. Diagnostic chart (Appendix C) will be filled with personal, medical and dental history.
2. The Intraoral examination will be made using mask, gloves, sterile gauze and wooden tongue depressors.
3. Patients who agreed to participate in the study will watch a video explaining how to perform oral hygiene.

   Intervention Group (Vitamin E) - The parents will be instructed to empty the oil contained within 100 IU soft gelatinous capsule which is equivalent to 100 mg of vitamin "E" (Pharco Pharmaceuticals, Egypt).

   - The capsule will be emptied into the child's oral cavity twice daily by piercing it with sterile wrapped needles.

   - Parents will be instructed to wear plastic gloves during these procedures.
   * For older children, the patients will be instructed to chew the vitamin "E" capsule and keep the oil in their mouth for few minutes then swallow it.
   * These procedures will be done on the day of chemotherapy infusion and 5 days after.
   * Follow up for the patient will be done at 7th, 14th and 21st day of chemotherapy infusion.

   Control Group:

   Standard protocol will be used (Voriconazole and Levofloxacin). Criteria for discontinuing intervention In case of any signs of allergy to vitamin E, the treatment will be terminated and the patient will be treated and excluded from the study.

   Strategies to improve adherence to intervention Face to face settings with the patients and their parents to stress on the importance of follow up. This will take place during the study period and during recruitment.

   Participants Timeline:

   Time point Enrollment Allocation Close out 0 7th 14th 21st Diagnostic chart and Intra oral examination X Application of Interventions X Follow up X x X

   Postoperative instructions



1. Patients are instructed to maintain oral hygiene care as tolerated using soft toothbrush and dental floss.
2. Lip lubrication (Vaseline or Cocoa butter) is instructed to be used.
3. Sugar free gums are advised to enhance oral moistness.
4. Avoidance of certain foods as acidic juices and spicy foods.

   Sample size:

   The aim of this study is to evaluate Prevention of Oral Mucositis After Using Oral Topical Vitamin E Versus Voriconazole and Levofloxacin in Pediatric Cancer Patients Receiving Chemotherapy. According previous researches and books as Isaac and Michael (1995) 10-30 participants will be satisfactory.

   Recruitment strategy:

   Pediatric Cancer patients attending in and Out Pediatric Oncology Units at the National Cancer Institute in Cairo, seeking chemotherapy. Patients will be enrolled in the study if they are compatible with the eligibility criteria.

   Randomization \& allocation concealment:

   A) Sequence generation:

   - Computer sequence generated random numbers will be used.

   - Randomization is done by computer software www.random.com.

   - The sequence generates 2 codes (A \& B).

   - Each code stands for either intervention or control.

   - The table with the numbers will be with the assistant supervisor.

   B) Allocation concealment mechanism:

   - A telephone call to the assistant supervisor will be done to know the group of the patient.

   C) Implementation:
   * Sequence will be generated by the assistant supervisor and provided through a telephone call.

   Bias:



1. Selection bias: is reduced by randomization using random number generator and allocation concealment.
2. Performance bias: One operator will perform the trial with a standardized method for all patients.
3. Detection: All outcomes will be detected.
4. Reporting: All outcomes will be reported.

Blinding:

- Blinding for outcome assessor and the statistician

Data management:

Data will be stored on the investigator's personal computer, secured with a password with backup for the data on Google Drive, on hard copy and backup external hard drive.

Monitoring:

The study work results will be monitored regularly by the supervisors.

Statistical method:

Data will be analyzed using IBM SPSS advanced statistics (Statistical Package for Social Sciences), version 24 (SPSS Inc., Chicago, IL). Numerical data will be described as mean and stander deviation or median and range. Categorical data will be described as number and percentage. Data will be explored for normality using Kolmogrov-Smirnv test and Shapiro-Wilk test. Comparisons between two groups for normally distributed numeric variable will be done using the student's test while for non normally distributed numeric variables will be done by the Mann-Whitney U test, Comparisons between categorical variables will be performed using the chi square test A p-value less than or equal to 0.05 will be considered statistically significant. All tests will be two tailed.

Harms:

Vitamin E is considered to have a very low allergic effect and is generally well-tolerated.

Auditing:

Auditing of the study design will be done by the Evidence Based Committee - Faculty of Dentistry - Cairo University.

Research Ethics Approval:

This study protocol and the informed consent form will be reviewed by the Ethics Committee of Scientific Research -National Cancer Institute and Faculty of Dentistry- Cairo University.

Protocol Amendments:

Any modifications to the protocol which may impact the conduct of the study, potential benefit of the patient or may affect patient safety, including changes of study objectives, study design, sample sizes, study procedures, or significant administrative aspect will require a formal amendment to the protocol. Such amendment will be agreed upon by the Council of Pediatric Dentistry and Dental Public Health Department.

Consent and assent:

Researcher will discuss the trial with legal guardian of each participating patient.

* Verbal assent will be taken orally from participating child.
* Written consent will be taken from the legal guardian of each participating child willing to participate in the trial. All consent forms will be translated into Arabic.

Confidentiality:

All study-related information will be stored securely. All participant information will be stored in locked file cabinets in areas with limited access.

Declaration of interests:

The study will be self-funded by investigator and carried out on patients from in or outpatient clinic in Pediatric Cancer Department, National Cancer Institute, Cairo.

Access to data:

Supervisors will be given access to the data sets. All data sets will be password protected.

post-trial care: - Preventive measures as oral hygiene measures will be offered for all participants.

Dissemination policy:

- Study results will be published as partial fulfillment of the requirements for Master degree in Pediatric Dentistry.

* Topics suggested for publication will be circulated to the authors.
* Thesis defense after completion of the study will be done in public with external judges.

Prevention of Oral Mucositis After Using Oral Topical Vitamin E Versus Voriconazole and Levofloxacin in Pediatric Cancer Patients Receiving Chemotherapy

Oral mucositis WHO Toxicity Scale (Paula Elaine et al., 2016)will be ranked according to WHO classification criteria (Appendix B):

* Grade 0: No change.
* Grade 1: Soreness/erythema. • Grade 2: Erythema, and Ulcers; patient can eat solids. • Grade 3: Ulcers; the patient requires liquid diet only. • Grade 4: Oral nourishment is not possible.

National Cancer Institute (NCI)

Cairo University

B.D.S, Faculty of Dentistry, Khartoum College of Medical Sciences, Sudan (2011)

Herbal and Botanical

Chamomile

1. The infusion of chamomile will be prepared in the clinic with 400 mL of distilled water and 10 g of chamomile flowers (Chamomile classic infusion, Royal Herbs).
2. Ice cubes will be prepared in special ice trays placed in the chemotherapy center for this purpose.
3. Patient will receive a cup of ice cubes which is continuously replenished before being emptied.
4. Patients will be instructed to swish the ice cubes around their oral cavities starting 5 minutes before chemotherapy infusion, continuing 30 minutes throughout the session and for additional 35 minutes after completion of intravenous chemotherapy session.

1. The plain icecubes will be prepared in the clinic with 400 mL of distilled water.
2. Ice cubes will be prepared in special ice trays placed in the chemotherapy center for this purpose.
3. Patient will receive a cup of ice cubes which is continuously replenished before being emptied.
4. Patients will be instructed to swish the ice cubes around their oral cavities starting 5 minutes before chemotherapy infusion, continuing 30 minutes throughout the session and for additional 35 minutes after completion of intravenous chemotherapy session.

The infusion of chamomile will be prepared in the clinic with 400 mL of distilled water and 10 g of chamomile flowers (Chamomile classic infusion, Royal Herbs). Patients are asked to swish the chamomile ice cubes around their oral cavities starting 5 minutes before chemotherapy infusion, continuing 30 minutes throughout the session and for additional 35 minutes after completion of intravenous chemotherapy session.

Chamomile oral cryotherapy

The plain icecubes will be prepared in the clinic with 400 mL of distilled water. Patients are asked to swish the ice cubes around their oral cavities starting 5 minutes before chemotherapy infusion, continuing 30 minutes throughout the session and for additional 35 minutes after completion of intravenous chemotherapy session.

Oral cryotherapy

Dina Y Essa, B.D.SC

Nada M Wassef, PHD

Dina Yousef

Norhan A Eldokkky, PHD

oral mucositis is a painful situation that significantly affects patients' quality of life with the severe cases being associated with ulcerated mucosa and secondary infection which may lead to life-threatening sepsis.Chamomile infusion in cryotherapy was used to aid in reduction of chemotherapy induced mucositis and to enhance the effect of standard cryotherapy alone by its anti-inflammatory, antifungal and antibacterial effect. The occurrence of oral mucositis is a significant complication of chemotherapy with prevalence of up to 80% in pediatric patients.The study is to be conducted at the in and outpatient clinics at the Department of Pediatric Oncology, National Cancer Institute,Egypt. A Structured interview questionnaire sheet will be filled with personal, medical and dental history. Intraoral examination will be carried out using sterile latex gloves, masks, plain mouth mirrors, sterile gauze and wooden tongue depressor. Patients who will agree to participate in the study will watch a video explaining how to perform oral hygiene.Preparation of the interventions is done in the clinic with 400 ml of distilled water with or without the infusion of 10 g of chamomile flowers."Chamomile classic infusion, Royal Herbs" .Ice cubes will be prepared in special ice trays placed in the chemotherapy center for this purpose.Patients will be instructed to swish the ice cubes around their oral cavities starting 5 minutes before chemotherapy infusion, continuing 30 minutes throughout the session and for additional 35 minutes after completion of intravenous chemotherapy session. Follow ups are done at the 8th,15th and the 21st day of interventions application.

Prevention of Oral Mucositis After Using Chamomile Oral Cryotherapy Versus Oral Cryotherapy in Pediatric Cancer Patients Receiving Chemotherapy.

Prevention of Oral Mucositis After Using Chamomile Oral Cryotherapy Versus Oral Cryotherapy in Pediatric Cancer Patients Receiving Chemotherapy: (A Randomized Pilot Study)

Primary outcome is measured using Children International Mucostitis Evaluation Scale (CHIMES).ChIMES1-4 each received a score of 0-5 where 5 is the worst degree of symptoms. ChIMES5 and ChIMES6 received a score of 1 or 0 if the child had received pain medications or not. Finally, ChIMES7 received a score of 1or 0 if oral ulcers were present or not. Any question that was scored as missing or 'I can't tell' was excluded from the total possible score. If all the questions were answered, the maximum score was 23. The ChIMES Total Score was the sum of all scores; 'I can't tell' responses and missing responses both received a score of 0. The ChIMES Percentage Score was the ChIMES Total Score over the total maximum score taking into account 'I can't tell' responses (by subtracting these items from the maximum score) multiplied by 100. Higher values indicate a worse outcome.

Assessed using Oral Mucositis World Health Organization Toxicity Scale.It represents grades of oral mucositis ranging from 0-4 with higher grades indicating worse outcome.

National Cancer Institute, Egypt

Master Degree Student

Wounds and Injuries

Neoplasms

Infections

Head and Neck Neoplasms

Gingivitis

Gingivitis, Necrotizing Ulcerative

Communicable Diseases

Fusobacterium Infections

Bacterial Infections

Gram-Negative Bacterial Infections

Mycoses

Bacterial Infections and Mycoses

Gingival Diseases

Periodontal Diseases

Analgesics

The MuReva Phototherapy System consists of Light Control Unit and two Mouthpiece Cable Assemblies. Subjects will begin device treatment photobiomodulation sessions on the first day of radiotherapy (RT) treatment. They will receive once-daily investigative device photobiomodulation treatments prior to radiation therapy (RT) with their assigned Mouthpiece for 5 days per week for the duration of their CRT treatment. Each device treatment session will last up to 5 minutes, not including up to 5 additional minutes for treatment breaks. All subjects will visit the study site once during the Screening period (Days -28 to 1) and an anticipated 30 to 40 times during the treatment period. Each patient will be assigned their own Mouthpiece Cable Assembly set.

The MuReva Phototherapy System (or sham control) is a Light Control Unit and a set of Mouthpiece Cable Assemblies. The sham control Mouthpiece Cable Assemblies will appear identical to the active Mouthpiece Cable Assembly, and will be used in the same manner as the active cohort. However, the sham control device will be configured where the mouthpiece will not emit any light at any time during the study. The same Light Control Unit will be used with sham and active Mouthpiece Cable Assemblies. Each patient will be assigned their own Mouthpiece Cable Assembly set.

Provide photobiomodulation therapy to subjects prior to each radiation therapy session.

Photobiomodulation

Standard oral care, oral hygiene and oral pain protocols

Routine Oral Care and Analgesia

Nancy B Lipko, MD MBA

The overall purpose of this clinical study is to evaluate safety and efficacy of the MuReva Phototherapy System with a light delivery mouthpiece to reduce the severity of oral mucositis (OM) in adult patients with squamous cell carcinoma of the oral cavity, oropharynx, tonsils and base of tongue receiving radiation therapy with or without concurrent chemotherapy.

Study Design: A prospective, multi-center, randomized, double-blind, placebo controlled, adaptive sample size, two-treatment parallel, pivotal clinical study.

Protocol-eligible subjects will be randomized in a 1:1 allocation to receive either the active MuReva Phototherapy System or a sham control. Both the subjects and clinician evaluating the patients will be blinded to the treatment assignments. The sham device will be placed in the patient's mouth and operated in the same manner as the active device, but not deliver any therapy.

Subjects will begin device treatment sessions on the first day of radiation treatment (RT) and will continue to receive once daily treatments prior to RT with their assigned device for 5 days per week for the duration of their RT treatment (approximately 6 to 8 weeks, for a total of 30 to 40 device sessions depending on the standard of care regimen for the type of cancer). Each device treatment session will last approximately 10 minutes in total. Light therapy parameters for the MuReva Phototherapy System will be as follows for all subjects receiving active light therapy: 660nm, 2-12 J/cm2 nominal fluence. Subjects who stay on RT treatment past 6 weeks will continue to receive treatment with their assigned devices up through 8 total weeks of treatment (for a maximum total of 40 phototherapy sessions). In addition, all subjects, regardless of randomization, will be kept on standard oral care, oral hygiene and oral pain protocols.

All subjects will visit the study site once during the Screening period (Days -28 to 1) and an anticipated 30 to 40 times during the treatment period (i.e., 5 days during each of the 6-8 RT treatment weeks). Weekly, subjects will be evaluated for oral mucositis and for device safety. The weekly assessments will continue through the final RT session. A post-therapy assessment will be done approximately 2 weeks after completion of RT. At the conclusion of this assessment each subject's participation in the study will be complete.

A prospective, multi-center, randomized, double-blind, placebo controlled, adaptive sample size, two-treatment parallel, pivotal clinical study.

The sponsor, clinical research organization (CRO), subjects, research staff and Investigators performing the weekly OM evaluations for the study will be blinded to the treatment assignments. Subjects will be mandated to use light-blocking eyewear.

Only the research staff delivering treatment will be unblinded. No other personnel or visitors will be allowed in the treatment room during active/sham treatment.

The Investigators will not administer the daily treatment and will not visit or observe the patient during device use in order to remain blinded. The Investigators will also remain blinded to the patients' responses to the weekly Self-Assessments.

Photobiomodulation to Demonstrate Safety and Reduce the Incidence of Oral Mucositis in Adult Head & Neck Cancer Patients

Photobiomodulation Therapy Using the MuReva Phototherapy System to Demonstrate Safety and Reduce the Incidence of Oral Mucositis in Adult Patients With Head and Neck Cancer Receiving Radiation Therapy With or Without Concurrent Chemotherapy

A description of this clinical trial will be available on http://www.ClinicalTrials.gov, as required by U.S. Law. This Web site will not include information that can identify individual subjects. At most, the Web site will include a summary of the results after the study is completed. You can search this Web site at any time.

If the results of this study are published, individual subject identity will remain confidential.

Data, salivary fluid specimens and photographs collected in this research might be de-identified (name and any identifying information will be removed) and used for future research or distributed to another investigator for future research.

The primary effectiveness endpoint of the study is the severity of oral mucositis as assessed by the Oral Mucositis Index (OMI) score, on a scale of 0-60.

The proportion of patients who have severe oral mucositis (Grade 3 or 4) at week 6 of treatment according to the World Health Organization (WHO) Oral Toxicity Scale.

Oral Mucositis Weekly Questionnaire-Head and Neck Cancer

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Prevention of Oral Mucositis After Using Oral Topical Vitamin E Versus Voriconazole and Levofloxacin in Pediatric Cancer Patients Receiving Chemotherapy	NCT03613389	Oral Mucositis ...	oral topical vi...	6 Years - 18 Years	Cairo University
Prevention of Oral Mucositis After Using Chamomile Oral Cryotherapy Versus Oral Cryotherapy in Pediatric Cancer Patients Receiving Chemotherapy.	NCT03605186	Oral Mucositis ...	Chamomile oral ... Oral cryotherap...	6 Years - 18 Years	Cairo University
Photobiomodulation to Demonstrate Safety and Reduce the Incidence of Oral Mucositis in Adult Head & Neck Cancer Patients	NCT03972527	Oral Mucositis ... Oral Mucositis ... Oral Mucositis ... Head and Neck C...	Photobiomodulat... Routine Oral Ca...	22 Years -	MuReva Phototherapy Inc.
Photobiomodulation to Demonstrate Safety and Reduce the Incidence of Oral Mucositis in Adult Head & Neck Cancer Patients	NCT03972527	Oral Mucositis ... Oral Mucositis ... Oral Mucositis ... Head and Neck C...	Photobiomodulat... Routine Oral Ca...	22 Years -	MuReva Phototherapy Inc.
Prevention of Oral Mucositis After Using Oral Topical Vitamin E Versus Voriconazole and Levofloxacin in Pediatric Cancer Patients Receiving Chemotherapy	NCT03613389	Oral Mucositis ...	oral topical vi...	6 Years - 18 Years	Cairo University
Prevention of Oral Mucositis After Using Chamomile Oral Cryotherapy Versus Oral Cryotherapy in Pediatric Cancer Patients Receiving Chemotherapy.	NCT03605186	Oral Mucositis ...	Chamomile oral ... Oral cryotherap...	6 Years - 18 Years	Cairo University

Spots Global Cancer Trial Database for oral mucositis (ulcerative) due to antineoplastic therapy