Neoplasms

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Carcinoma

Endometrial Neoplasms

Uterine Neoplasms

Genital Neoplasms, Female

Urogenital Neoplasms

Uterine Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Antineoplastic Agents

All Drugs and Chemicals

Paclitaxel

Carboplatin

Albumin-Bound Paclitaxel

Tubulin Modulators

Antimitotic Agents

Paclitaxel: 175 mg/m(2) intravenously (IV); followed by Paraplatin (Carboplatin Injection) AUC=5 IV. 3-6 cycles as necessary.

1. Histopathological grade G3 and \<50% myometrial invasion: Vaginal brachytherapy 5Gy, 3 times;
2. Histopathological grade G3 and vascular space involvement: Pelvic radiation 45-50 Gy;
3. ≥50% myometrial invasion: Pelvic radiation 50 Gy + Vaginal brachytherapy 5Gy, 2-4 times.

Paraplatin (Carboplatin Injection)

Pelvic Radiation

Vaginal Brachytherapy 1

Vaginal brachytherapy 2

Beihua Kong, MD, PhD

This randomized trial is studying the efficacy and safety of the chemotherapy compared with radiation therapy alone as adjuvant treatment after operation in Patients with high risk and Stage I endometrial carcinoma.

The Efficacy and Safety of the Postoperative Adjuvant Treatment in Patients With High-risk Stage I Endometrial Carcinoma

A Multicenter, Prospective, Randomized Trial of the Efficacy and Safety of the Postoperative Adjuvant Treatment in Patients With High-risk Stage I Endometrial Carcinoma

The incidence of infusion reactions (i.e.,skin reactions, cardiovascular reactions, respiratory or throat tightness), and allergic reactions (i.e., life-threatening anaphylaxis)

To observe the subtle effect on quality of life (e.g., diarrhea, bowel symptoms) and vaginal stenosis.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
The Efficacy and Safety of the Postoperative Adjuvant Treatment in Patients With High-risk Stage I Endometrial Carcinoma	NCT01820858	Endometrial Neo...	Paclitaxel Paraplatin (Car... Pelvic Radiatio... Vaginal Brachyt... Vaginal brachyt...	18 Years - 65 Years	Huazhong University of Science and Technology
The Efficacy and Safety of the Postoperative Adjuvant Treatment in Patients With High-risk Stage I Endometrial Carcinoma	NCT01820858	Endometrial Neo...	Paclitaxel Paraplatin (Car... Pelvic Radiatio... Vaginal Brachyt... Vaginal brachyt...	18 Years - 65 Years	Huazhong University of Science and Technology

Spots Global Cancer Trial Database for paraplatin (carboplatin injection)