Neoplasms

Digestive System Diseases

Gland and Hormone Related Diseases

All Conditions

Rare Diseases

Pancreatic Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Endocrine Gland Neoplasms

Gastrointestinal Diseases

Pancreatic Diseases

Endocrine System Diseases

Pancreatic Cancer

Central Nervous System Depressants

All Drugs and Chemicals

Platelet Aggregation Inhibitors

Adjuvants, Anesthesia

Analgesics

Herbal and Botanical

Anesthetics

Ropivacaine

Sevoflurane

Sufentanil

Dsuvia

General anesthesia combined with epidural anesthesia will be performed during surgery and patient-controlled epidural analgesia (PCEA) will be provided after surgery.

General anesthesia will be performed during surgery and patient-controlled intravenous analgesia (PCIA) will be provided after surgery.

Thoracic epidural catheterization will be performed and epidural anesthesia will be maintained with 0.25% ropivacaine during surgery. General anesthesia will be maintained with inhalation (sevoflurane) and muscle relaxants will be administered when considered necessary.

Patient-controlled epidural analgesia (0.15% ropivacaine and 0.5ug/ml sufentanil infusion) will be provided after surgery.

PCEA

General anesthesia will be maintained with inhalation (sevoflurane) and sufentanil infusion, and muscle relaxants will be administered when considered necessary.

Patient-controlled intravenous analgesia (1ug/ml sufentanil) will be provided after surgery.

PCIA

Changhong Miao

Xuqin Zhu

Jing Cang

Yingwei Wang

Qianjin Liu

The purpose of this randomized controlled clinical trial is to investigate the effects of epidural block on overall survival，disease-free survival and recovery in patients with pancreatic cancer undergoing distal pancreatectomy. This study will also evaluate the effects of this technique on neuroendocrine, stress and inflammatory response in these patients.

Effects of Epidural Block on the Prognosis in Patients With Pancreatic Cancer Undergoing Distal Pancreatectomy

Effects of Epidural Block on the Prognosis in Patients With Pancreatic Cancer Undergoing Distal Pancreatectomy----A Multi-center Randomized Controlled Trial

Defined and calculated as the time from the date of surgery to death related to all reasons

Defined and calculated as the time from the date of surgery to the first time of pancreatic cancer recurrence or metastasis or cancer-related death

Assessed with visual analogue score ( 0 is no pain and 10 is the most severe pain)

Assessed for delirium using the 3D-CAM instrument

Changes of blood epinephrine, norepinephrine, cortisol, VEGF, interleukin-6 (IL-6)、interleukin-8 (IL-8), peripheral blood NLR ( neutrophil-lymphocyte ratio)

Washington University School of Medicine

Fudan University

Director of Anesthesiology Department of Fudan University Shanghai Cancer Center

Patient-controlled epidural analgesia (0.15% ropivacaine infusion) will be provided after surgery.

Changhao Miao

The purpose of this randomized controlled trial is to investigate the effects of epidural anesthesia and analgesia on the overall survival，disease-free survival and recovery in patients undergoing pancreatic cancer surgery. This study will also evaluate the effects of this technique on neuroendocrine, stress and inflammatory response in these patients.

Effects of Epidural Anesthesia and Analgesia on the Prognosis in Patients Undergoing Pancreatic Cancer Surgery

Effects of Epidural Anesthesia and Analgesia on the Prognosis in Patients Undergoing Pancreatic Cancer Surgery: A Multi-center Randomized Controlled Trial

Measured by the time of first enteral tube feeding after surgery

Symptoms and General Pathology

Nervous System Diseases

Pain, Postoperative

Liver Neoplasms

Pain

Postoperative Complications

Neurologic Manifestations

Hematinics

Liver Extracts

general anesthesia with post-operative IV PCA with a standard demand pump

general anesthesia with post-operative thoracic epidural analgesia with a standard demand pump

Patients undergoing IV PCA for pain control will have intravenous (IV) analgesia provided through a demand pump started in the recovery room.

IV PCA

Patients in this group will have the epidural catheter placed by the anesthesia pain service team in the pre-surgical center (PSC) as performed routinely at MSKCC. The epidural will be used intra-operatively at the end of liver resection phase of the surgical procedure, once the specimen has been extracted, and continued subsequently in the post-operative phase for pain management.

Vittoria Arslan-Carlon, MD

The purpose of this study is to learn whether patient-controlled epidural analgesia (PCEA) is a better method for managing pain after liver resection compared to patient-controlled analgesia (IV PCA). Currently, the standard pain control method for liver resection patients is IV PCA. There is not enough data on how epidural (PCEA) relieves pain and movement on a day to day basis after liver resection.

Patient Controlled Epidural Analgesia Versus Intravenous Patient Controlled Analgesia for Post-Operative Pain Control in Patients Undergoing Elective Liver Resection

A Prospective Randomized Controlled Clinical Trial of Patient Controlled Epidural Analgesia Versus Intravenous Patient Controlled Analgesia for Post-Operative Pain Control in Patients Undergoing Elective Open Liver Resection

The primary endpoint assesses differences in pain control between PCEA and IV PCA after a "get up and go" test performed on POD2 during pain rounds, evaluated using a NRS pain score.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Effects of Epidural Block on the Prognosis in Patients With Pancreatic Cancer Undergoing Distal Pancreatectomy	NCT03659292	Cancer of Pancr...	GEA PCEA GA PCIA	18 Years - 80 Years	Fudan University
Effects of Epidural Anesthesia and Analgesia on the Prognosis in Patients Undergoing Pancreatic Cancer Surgery	NCT03245346	Cancer of Pancr...	GEA PCEA GA PCIA	18 Years -	Fudan University
Patient Controlled Epidural Analgesia Versus Intravenous Patient Controlled Analgesia for Post-Operative Pain Control in Patients Undergoing Elective Liver Resection	NCT02523443	Liver Cancer Pain Management	IV PCA PCEA	18 Years -	Memorial Sloan Kettering Cancer Center
Effects of Epidural Block on the Prognosis in Patients With Pancreatic Cancer Undergoing Distal Pancreatectomy	NCT03659292	Cancer of Pancr...	GEA PCEA GA PCIA	18 Years - 80 Years	Fudan University
Patient Controlled Epidural Analgesia Versus Intravenous Patient Controlled Analgesia for Post-Operative Pain Control in Patients Undergoing Elective Liver Resection	NCT02523443	Liver Cancer Pain Management	IV PCA PCEA	18 Years -	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for pcea

Every month we try and update this database with for pcea cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for pcea

Every month we try and update this database with for pcea cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for pcea cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.