Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Urinary Bladder Neoplasms

Urologic Neoplasms

Urogenital Neoplasms

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Urinary Bladder Diseases

Urologic Diseases

Male Urogenital Diseases

Patients will receive pelvic reconstruction following radical cystectomy during the operation.

Patients will not receive pelvic reconstruction following radical cystectomy during the operation.

After radical cystectomy, the pelvic reconstruction including the ligation of dorsal vascular complex and posterior reconstruction will be performed on patients.

pelvic reconstruction

Kaiwen Li, MD

Jian Huang, MD

To study the effect of pelvic reconstruction on early return of continence after robot-assisted radical cystectomy-orthotopic ileal neobladder in the male.

This study will enroll male patients with bladder cancer who will undergo robot-assisted radical cystectomy-orthotopic ileal neobladder. The patients will be distributed into two comparable groups according to whether received pelvic reconstruction or not. Patient demographics and pathologic, perioperative, functional, and oncologic outcomes will be compared between the two groups.

Application and Clinical Effectiveness of Pelvic Reconstruction in Robot-assisted Radical Cystectomy-orthotopic Ileal Neobladder in the Male

Patients were considered continent when they required 0 or 1 safety pad during the day or at night.

First Affiliated Hospital, Sun Yat-Sen University

Third Affiliated Hospital, Sun Yat-Sen University

The Seventh Affiliated Hospital of Sun Yat-sen University

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Symptoms and General Pathology

Digestive System Diseases

Recurrence

Postoperative Complications

Neoplasm Recurrence, Local

Rectal Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Intestinal Diseases

Rectal Diseases

Disease Attributes

Neoplastic Processes

patients underwent cylindrical abdominoperineal resection for advanced very low rectal cancer

patients underwent conventional abdominoperineal resection for advanced very low rectal cancer

Extended abdominoperineal resection with human acellular dermal matrix reconstruction of the pelvic floor for rectal cancer

cylindrical abdominoperineal resection

Zhen Jun Wang, M.D.

Jia Gang Han, M.D.

Jian Hua Cai, M.D.

Hua Chong Ma, M.D.

Yan Fu Du, M.D.

Min Zhe Li, M.D.

Wei Tang Yuan, M.D.

Qun Qian, M.D.

Xian Dong Zeng, M.D.

Yong Dai, M.D.

Heng Ma, M.D.

The purpose of this study is to determine whether cylindrical abdominoperineal resection is effective in the treatment of advanced very low rectal cancer

Abdominoperineal resection (APR) is still a common operation in patients with tumours less than 6 cm from the anal verge. The perineal phase of APR is a difficult part of the operation, often done with the patient in the supine position.The risk of inadvertent bowel perforation is high, the resulting specimen frequently has a waist at the lower border of the mesorectum, and the circumferential resection margin (CRM) is often close to the rectal muscle tube. The cylindrical APR may be performed via an extended posterior perineal approach, that aims to create a more cylindrical specimen without a waist. The potential benefit of this technique is a reduction in the risk of bowel perforation and tumour involvement of the CRM, and thus in the risk of local recurrence.

Perineal wounds in patients following APR are at considerable risk for infection, dehiscence and delayed healing when closed primarily. This can be further increased in patients who have received neoadjuvant chemoradiation therapy. The adoption of extended resection, such as the cylindrical APR, may cause additional risks. The use of acellular biomaterials, including human acellular dermal matrix (HADM) has drawn great interest for the complex abdominal wall reconstruction.

The purpose of this study is to determine whether cylindrical abdominoperineal resection is effective in the treatment of advanced very low rectal cancer, and to determine the initial results of pelvic reconstruction using human acellular dermal matrix after cylindrical abdominoperineal resection.

circumferential resection margin; bowel perforation; cross sectional tissue area outside the internal sphincter; mean distance from the internal sphincter to the anterior, posterior and lateral circumferential resection margins

Safety and Efficacy Study of Cylindrical Abdominoperineal Resection to Treat Rectal Cancer

A Randomized, Controlled, Multicenter Trial to Evaluate the Safety and Efficacy of Cylindrical Abdominoperineal Resection in the Treatment of Advanced Very Low Rectal Cancer

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Application and Clinical Effectiveness of Pelvic Reconstruction in Robot-assisted Radical Cystectomy-orthotopic Ileal Neobladder in the Male	NCT04958343	Bladder Cancer	pelvic reconstr...	18 Years -	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Safety and Efficacy Study of Cylindrical Abdominoperineal Resection to Treat Rectal Cancer	NCT00949273	Rectal Cancer Treatment Postoperative C... Neoplasm Recurr... Survival Rate	cylindrical abd...	18 Years - 80 Years	Beijing Chao Yang Hospital

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