Symptoms and General Pathology

All Conditions

Neoplasms

Digestive System Diseases

Recurrence

Neoplasm, Residual

Colonic Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Neoplastic Processes

Adjuvants, Anesthesia

Analgesics

Central Nervous System Depressants

All Drugs and Chemicals

Herbal and Botanical

Sufentanil

Bupivacaine

Morphine

Dsuvia

Pirinitramide

Analgesics, Opioid

Narcotics

Cola

Patients will receive perioperative epidural analgesia. Drugs: bupivacaine 1.25 mg/ml and sufentanil 0.5 mcg/ml Form and frequency: continuous infusion Dosage: 4 - 14 ml/h with boluses 2 - 4 ml based on pain assessment Duration: as long as required

Patients will receive postoperative analgesia with piritramide. Drugs: piritramide 1.0 mg/ml Form and frequency: continuous infusion Dosage: 0 - 4 ml/h with boluses 2 - 4 ml based on pain assessment Duration: as long as required

Patients will receive postoperative analgesia with morphine. Drugs: morphine 1.0 mg/ml Form and frequency: continuous infusion Dosage: 0 - 4 ml/h with boluses 2 - 4 ml based on pain assessment Duration: as long as required

Epidural analgesia

Piritramide

Emil Berta, MD PhD

The aim of this study is to compare the effects of three types of perioperative analgesia on the number of circulating cancer cells (representing minimal residual disease) following radical colon cancer surgery. Patients will be randomized into one of three groups. The intervention group will receive combined regional and general anesthesia during surgery and postoperative epidural analgesia. The two control groups will receive balanced general anesthesia and either morphine-based or piritramide-based postoperative analgesia. We hypothesize that epidural analgesia will be favorable to both piritramide-based and morphine-based analgesia and that piritramide-based analgesia will be favorable to morphine-based analgesia with regard to the number of circulating cancer cells and its development in the early postoperative period.

Techniques of regional analgesia such as epidural analgesia may favorably influence metastasis development following cancer surgery compared to analgesia based on strong opioids such as morphine or piritramide. These beneficial effects, if present, are probably attributable to less immunosuppression of antimetastatic immune defenses.

The aim of this study is to identify techniques of perioperative analgesia with the potential to prevent metastasis development in patients undergoing open radical colon cancer surgery. In the early postoperative period, a relationship between metastasis development and the number of circulating cancer cells representing minimal residual disease has been shown. Therefore, effects of epidural, morphine-based and piritramide-based analgesia on the number of circulating cancer cells will be compared at several time points during the peroperative and early postoperative periods. The number of circulating cancer cells will be assessed in peripheral venous blood samples using real-time polymerase chain reaction. Perioperative care will be standardized and patients will be followed by clinical observation, laboratory analyses and monitoring instrumentation daily during their hospital stay.

Effects of Different Types of Perioperative Analgesia on Minimal Residual Disease Development After Colon Cancer Surgery

Number of circulating cancer cells will be measured in venous blood samples. The quantitative real-time polymerase chain reaction using carcinoembryonic antigen and cytokeratine 20 as markers for circulating cancer cells will be used for minimal residual disease detection.

Self reported pain intensity. Scale: 0 = no pain, 10 = worst pain imaginable. A score 0-10 will be recorded every four hours.

Brno University Hospital

Tomas Bata Hospital, Czech Republic

The Institute of Molecular and Translational Medicine, Czech Republic

Senior Researcher

Nervous System Diseases

Behaviors and Mental Disorders

Rare Diseases

Esophageal Neoplasms

Agnosia

Perceptual Disorders

Neurobehavioral Manifestations

Neurologic Manifestations

Head and Neck Neoplasms

Esophageal Diseases

Esophageal Cancer

Antiemetics

Dermatologic Agents

Gastrointestinal Agents

Anti-Inflammatory Agents

Antirheumatic Agents

Anesthetics

Ondansetron

Flurbiprofen

Flurbiprofen axetil

Anti-Inflammatory Agents, Non-Steroidal

Analgesics, Non-Narcotic

Cyclooxygenase Inhibitors

Enzyme Inhibitors

50mg once，30min before induction anesthesia

Preemptive flurbiprofen axetil

Postoperative flurbiprofen axetil

Sufentanil 2.5 μg/kg+ondansetron 8mg, prepared to 100ml normal saline; background dose: 2 ml/h, single press analgesic pump injection volume: 0.5 ml, locking time: 15 min.

Patient-controlled analgesia pump

zhu zhixiang

This study was designed to compare analgesic efficacy and safety of different perioperative analgesic modes in minimally invasive esophagectomy for esophageal cancer.

Perioperative Analgesia Modes in Minimally Invasive Esophagectomy

Comparison of Efficacy and Safety of Different Analgesic Modes in Minimally Invasive Esophagectomy for Esophageal Cancer

In the Visual Analog Score to be used as the pain measurement criterion, '0' is the minimum value that indicates no pain, while '10' is the maximum value that defines the most severe pain.

Time from the end of surgery to the first flatus.

Time from the end of surgery to the first defaecation.

Abdominal distension was measured using a scoring system, '0' is the minimum value that indicates no abdominal distension, while '10' is the maximum value that defines the most severe abdominal distension.

Nausea and vomiting were measured using a scoring system(0 = no nausea, 1 = only nausea, 2 = both nausea and vomiting).

Time from the end of surgery to the first postoperative ambulation

Time from the end of surgery to discharge from the hospital

Rate of pulmonary infection up to 30 days after surgery

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Neoplastic Cells, Circulating

Rectal Diseases

Neoplasm Metastasis

Perioperative epidural analgesia containing an opioid

Piritramid

Epidural

Marian Hajduch, MD PhD

To compare the effects of three types of perioperative analgesia on the number of circulating tumor cells following radical colorectal cancer surgery. To find correlations with other perioperative factors and clinical/pathological disease characteristics.

Influence of Opioid Analgesia on Circulating Tumor Cells in Open Colorectal Cancer Surgery

Influence of Peri-operative Opioid Analgesia on Circulating Tumor Cells in Patients Undergoing Open Colorectal Cancer Surgery - Multi-center, Randomized Clinical Trial

Baseline number of circulating tumor cells will be recorded prior to surgery in a venous blood sample. Number of circulating tumor cells will be measured 2 - 4 weeks after surgery in a venous blood sample. These two values will be compared.

Pain intensity assessed using Numerical Rating Scale (0-10)

General University Hospital, Prague

University Hospital Ostrava

Hospital Novy Jicin

Skin and Connective Tissue Diseases

Breast Neoplasms

Pain, Postoperative

Nausea

Pain

Vomiting

Postoperative Nausea and Vomiting

Postoperative Complications

Signs and Symptoms, Digestive

Anti-Arrhythmia Agents

Channel Blockers

Lidocaine

Serratus plane block will be applied after induction of general anesthesia.

Serratus plane plus pectoral I block will be applied after induction of general anesthesia.

0.5 ml /kg Bupivacaine/lidocaine mixture will be injected onto the serratus muscle

Serratus Plane Block

0.5 ml / kg %0.25 Bupivacaine/ %1 lidocaine mixture will be injected onto the serratus muscle and injected between the pectoralis minor/pectoralis major muscles.2/3 of the total drug will be applied for the serratus plane block and 1/3 of the total drug for the pectoral I block. If the total amount of the drug is less than 30 ml, it will be completed with isotonic saline to 30 ml.

Serratus Plane Block plus Pectoral I Block

Serdar Yeşiltaş, MD

Breast cancer is the most common malignancy in women at worldwide. Even a minor breast surgery can cause significant postoperative pain (PP) (1). PP could be converted into chronic pain in 25-40% of cases. Inadequate PP control is associated with increased morbidity, delay in wound healing, prolonged hospital stay, increased opioid use, increased side effects and high cost of care. For these reasons, regional anesthetic techniques are recommended for effective PP management. Some of recent studies suggest that ultrasound-guided pectoral I (PI), pectoral II (PII) and serratus plan block (SPB) may be an alternative to thoracic epidural analgesia and paravertebral block applications because of the ease of administration, low side effect profile and adequate analgesia in breast surgery. (2,3).

In breast surgeries, the serratus plane block has recently been described and rapidly became popular. The serratus plane block is called the modified pectoral II block. Local anesthetic drugs are injected onto the serratus muscle by targeting thoracodorsal nerve, thoracicus longus nerve, lateral and anterior branches of the T2-T9 intercostal nerves. In the pectoral I (Pecs I) block, the medial and lateral pectoral nerves of the brachial plexus are targeted. Additionally, Pecs I block can be effective for analgesia in axillary dissection. In the literature, there are studies comparing pectoral I + II blocks and serratus plane block in terms of analgesic efficacy in breast surgery. The aim of this study was to evaluate the postoperative analgesic efficiency of serratus plane block and serratus plan block plus pectoral I block combination.

Participans will be informed about the potential benefits and complications after the study protocol has been fully and thoroughly explained. After premedication with 0.03 mg / kg iv midazolam, participans will be noninvasively monitored by taking into the operating room (heart rate, blood pressure, pulse oximetry). Anesthesia induction will delivered with fentanyl 1mcg / kg, propofol 1.5-2 mg / kg and rocuronium 0.5 mg / kg. The maintenance of anesthesia will be achieved by infusion of sevoflurane 1-3% in 50% O2/50% medical air. The depth of anesthesia will be evaluated with bispectral index monitoring and will be kept between 40 and 60.. Thirty minutes before end of the surgery, all patients were intravenously administered 20 mg tenoxicam HCl and 1gr paracetamol.

SPB plus Pecs I block technique: Bupivacaine/lidocaine mixture will be injected onto the serratus muscle and injected between the pectoralis minor/pectoralis major muscles.

SPB technique: Bupivacaine/lidocaine mixture will be injected onto the serratus muscle.

After the surgery, 1 g paracetamol was intravenously administered once every 8 h. Postoperative pain was assessed using VAS (VAS 0 = no pain, VAS 10 = most severe pain ). Morphine 0.1mg / kg will be used as rescue analgesic drug.Duration at PACU was recorded right from 0 h. VAS scores at 0, 1,2, 6, 12 and 24 h were recorded. PONV was evaluated using a numeric ranking scale (0 = no PONV, 1 = mild nausea, 2 = severe nausea or vomiting once attack, and 3 = vomiting more than once attack). If PONV score was \>2, the antiemetic metoclopramide Hcl 10mg was intravenously administered.

Serratus Plane Plus Pectoral I Block Versus Serratus Plane Block for Perioperative Analgesia in Breast Cancer Surgery

Does Serratus Plane Plus Pectoral I Block Provide Better Perioperative Analgesia in Ambulatory Breast Cancer Surgery When Compared to Serratus Plane Block Alone

Self reported pain intensity in the postoperative 0, 1,2,6,12 and 24 hour. Each item is scored 0-10 (0: no pain 10: pain as bad as can be)

If pain intensity score \>4 morphine 0,1 mg/kg will be given to the patient. The total amount of morphine requirement will be recorded.

Nausea and vomiting intensity score measured by numeric rank score (0:no nausea and no vomiting, 1: have nausea, no vomiting, 2: once vomiting, 3: two or more vomiting).

Will be scored between 1-5 (1- very bad 5-very good).

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Effects of Different Types of Perioperative Analgesia on Minimal Residual Disease Development After Colon Cancer Surgery	NCT02314871	Colon Cancer Minimal Residua...	Epidural analge... Piritramide Morphine	18 Years -	The Institute of Molecular and Translational Medicine, Czech Republic
Effects of Different Types of Perioperative Analgesia on Minimal Residual Disease Development After Colon Cancer Surgery	NCT02314871	Colon Cancer Minimal Residua...	Epidural analge... Piritramide Morphine	18 Years -	The Institute of Molecular and Translational Medicine, Czech Republic
Perioperative Analgesia Modes in Minimally Invasive Esophagectomy	NCT05504265	Esophageal Canc... Perioperative A... NSAIDs Opioid Patient-control...	Preemptive flur... Postoperative f... Patient-control...	18 Years - 75 Years	Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Influence of Opioid Analgesia on Circulating Tumor Cells in Open Colorectal Cancer Surgery	NCT03700411	Colorectal Canc... Circulating Tum...	Morphine Piritramid Epidural	18 Years -	The Institute of Molecular and Translational Medicine, Czech Republic
Serratus Plane Plus Pectoral I Block Versus Serratus Plane Block for Perioperative Analgesia in Breast Cancer Surgery	NCT03899545	Postoperative P... Postoperative N... Patient Satisfa... Narcotic Use	Serratus Plane ... Serratus Plane ...	20 Years - 75 Years	Bezmialem Vakif University

Spots Global Cancer Trial Database for perioperative analgesia