Neoplasms

All Conditions

Head and Neck Neoplasms

Photon intensity modulated radiation therapy (IMRT) to standard dose of 60-66Gy in standard 2 Gy per fraction.

Photon intensity modulated radiation therapy (IMRT)

Proton beam radiotherapy (PBRT) to standard dose of 60-66Gy in standard 2 Gy per fraction.

Proton beam radiotherapy (PBRT)

Nancy Lee, MD

Christopher Barker, MD

Noah Kalman, MD

Robert Foote, MD

Compared to IMRT, PBRT is thought to give less radiation exposure to the surrounding healthy tissues. It is possible that side effect rates with PBRT will be lower or the same compared to IMRT, but this has not been well studied to date. Although both of these radiation therapies have been used in the past to treat head and neck cancer, this research study will compare the effects of these two different radiation treatment modalities with each other to see whether PBRT is better, the same or worse than IMRT.

This is a phase II randomized two-arm trial comparing proton-beam radiation therapy (PBRT) with photon- based intensity-modulated radiation therapy (IMRT) for cancers in the head and neck region requiring ipsilateral radiation.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Study of Proton Versus Photon Beam Radiotherapy in the Treatment of Head and Neck Cancer	NCT02923570	Head and Neck C...	Photon intensit... Proton beam rad...	18 Years -	Memorial Sloan Kettering Cancer Center
Study of Proton Versus Photon Beam Radiotherapy in the Treatment of Head and Neck Cancer	NCT02923570	Head and Neck C...	Photon intensit... Proton beam rad...	18 Years -	Memorial Sloan Kettering Cancer Center
Study of Proton Versus Photon Beam Radiotherapy in the Treatment of Head and Neck Cancer	NCT02923570	Head and Neck C...	Photon intensit... Proton beam rad...	18 Years -	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for photon intensity modulated radiation therapy (imrt)