Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Nervous System Diseases

Symptoms and General Pathology

Lung Neoplasms

Sarcopenia

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Atrophy

Muscular Atrophy

Neuromuscular Manifestations

Neurologic Manifestations

Pathological Conditions, Anatomical

During hospitalization, patients will be given routine exercise and dietary guidance.

On the basis of routine care, participants who meet the inclusion and exclusion criteria will be guided to undergo low-load blood flow restriction training. Based on the constructed "Low load Blood Flow Restriction Training Program for Chemotherapy Stage Lung Cancer Patients with Sarcopenia", participants will be guided to undergo low-load blood flow restriction training.

On the basis of routine care, progressive resistance training will be conducted on subjects who meet the inclusion and exclusion criteria, guided by the progressive resistance training program for malignant tumor patients in the "ACSM Exercise Testing and Exercise Prescription Guidelines: 10th Edition" published by the People's Health Press.

Low load blood flow restriction training will be conducted on the subjects three times a week. Each training session includes upper and lower limb training, with 4 groups trained and repeated 30, 15, 15, and 15 times for each group. Train for a total of 12 weeks.The resistance strength will remain at 30% RM for weeks 1-12.

Low load blood flow restriction training

The subjects will undergo progressive resistance training three days a week, three groups per day, with each group repeating 10 times. Training includes upper and lower limbs. The resistance load increases over time, with a resistance load of 30% RM for weeks 1-4, 50% RM for weeks 5-8, and 70% RM for weeks 9-12.

Progressive resistance training group

Xin Wang

The goal of this clinical trial is to verify the effectiveness and safety of the low load blood flow restriction training program. The intervention effect, tolerance and compliance of low load blood flow restriction training and progressive resistance training on lung cancer patients complicated with sarcopenia during chemotherapy will be compared, in order to provide new ideas for improving or reversing sarcopenia.

The main questions it aims to answer are:

Can low load blood flow restriction training improve sarcopenia in chemotherapy induced lung cancer patients? Which training method is more effective and tolerable between low load blood flow restriction training and progressive resistance training?

Participants will be randomly divided into 3 groups：

1. Routine care group (Control group, CON): The researchers will provide participants with regular exercise and dietary guidance.
2. Low load blood flow restriction group (LL-BFRT): The researchers will provide participants with a low load blood flow restriction training program constructed by our research group.
3. Progressive resistance training group (PRE): The researchers will provide participants with progressive resistance training.

Construction and Effect Evaluation of the Low Load Blood Flow Restriction Training Program for Lung Cancer Patients Complicated With Sarcopenia During Chemotherapy

The grip strength of the participant's preferred hand

Using a human body composition analyzer (ICOMEON-FI2001B) to measure the skeletal muscle mass (ASM) of the limbs, and calculating ASMI using a formula. ASMI=ASM/height\^2

Measure height and weight using height measuring instruments and scales

Using the QLQ-LC 43 scale to measure the quality of life in lung cancer patients

This includes participation rate, interruption rate (number of missed training sessions), termination rate (termination of training before 12 weeks), and dose adjustment rate (adjustment of training load or frequency)

Record the frequency and time of adverse events caused by exercise, such as muscle pain, joint pain, dizziness, skin bruising, etc., and calculate the incidence rate of adverse events

Graduate student

Skin and Connective Tissue Diseases

Breast Neoplasms

Breast Diseases

Skin Diseases

Aerobic Training to Improve Functional Ability After Breast Cancer Surgery

Aerobic Training

Progressive Resistance Training to Improve Functional Ability After Breast Cancer Surgery

Progressive Resistance Training

Shama Zahid, DPT

To determine the effect of aerobic training and progressive resistance training to improve upper limb functional ability after breast cancer surgery

Comparison of AT & PR Training to Improve Functional Ability After Breast Cancer Surgery

Comparison of Aerobic Training and Progressive Resistance Training to Improve Functional Ability After Breast Cancer Surgery

Superior University

Principal Investigator

Weight Loss

Head and Neck Neoplasms

Body Weight

Body Weight Changes

12 weeks progressive resistance training (PRT) during and after concomitant chemoradiotherapy. Also optional/voluntary physical activity performed on their own is registered, as well as diet diary.

Control arm. Optional/voluntary physical activity performed on their own is registered, as well as diet diary.

12 weeks supervised resistance training program. Details of the program: 12 weeks, 3 sessions per week, 7 exercises in training machines (leg press, leg curl, hamstring curl, chest press, lateral pull down, sit-ups and back extensions). In general 2-3 sets of 8-15 repetitions will be performed following a progression plan starting with more repetitions at lower intensity progressing to fewer repetitions at higher intensity during the 12-week period (American College of Sports Medicine Position Stand)

Weekly diary of performed physical activity using the Physical Activity Score (PAS) during the 12-weeks intervention

physical activity

Weekly diet diary during the 12-weeks intervention

Diet diary

Julie Gehl

72 patients with head and neck cancer, undergoing primary treatment with radiation therapy and concomitant weekly cisplatin, will be recruited to this multicentre trial.

Randomized 1:1 to either 12-week progressive resistance training (PRT) program or control arm, starting together with concomitant chemoradiotherapy (CCRT) Stratified by centre, gender, p16-status and body mass index (BMI) below or above 30.

Primary endpoint is difference in change in lean body mass (LBM) between the groups and the endpoint is reduction of LBM loss in intervention arm by 25% compared to control.

Secondary endpoints include side-effects to treatment, change in body composition, physical function and strength, and compliance to PRT. Questionnaires on QoL, diet, voluntary exercise and work affiliation will also be registered.

Blood samples for explorative analyses will be drawn and optional muscle biopsies drawn for proteomics analyses and histological analyses.

The PRT program will start about the onset of radiotherapy. The program consists of 7 exercises in training machines and involves the major muscle groups of the body.

The program has previously been found to successfully restore the loss of lean body mass (LBM) in head and neck cancer patients post-treatment. A group based approach will be used to facilitate a social and motivating training environment for the patients. A pilot study (NCT02068950) showed feasibility of PRT during CCRT.

In addition to baseline data (height, tumor stage, performance status, etc), the following parameters will be registered: Weight, patient reported side effects, as well as a questionnaire on amount of physical activity and food intake.

Physical function and strength will be tested at baseline, after the course of chemoradiotherapy and at the end of the 12-week PRT programme, and at 6 and 12 months follow-up. DXA scans for body composition will be performed using a Lunar iDXA (GE Healthcare).

Blood samples will be drawn at regular intervals during the 12 weeks and at follow-up.

Patient reported quality of life (EORTC Quality of Life Questionnaire (QLQ)-C30 and QLQ-H\&N35) will also be registered.

Muscle biopsies will be taken three times: at baseline, after treatment and after 12-weeks PRT.

Study duration is expected to be 18 months and an additional 12 months for follow-up.

Progressive Resistance Training in Head and Neck Cancer Patients During Concomitant Chemoradiotherapy

Progressive Resistance Training in Head and Neck Cancer Patients During Concomitant Chemoradiotherapy - The DAHANCA 31 Study

measured by PAS (physical activity scale)

No. of days from end of radiotherapy until back at work at full time (or the hours of work per week as before therapy)

Percent of patients having relapse within 12 months after radiotherapy

Measurement of different cytokines, changes over time and after bout of PRT. Will be measured regularly during the 12 weeks of PRT.

protein will be measured using the proteomic approach. Muscle fiber type and size will be evaluated.

Study specific questionnaire regarding pros and cons of attending the study

Measuring NK-cells. NK-cells may increase after exercise and show tumor inhibiting effect.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Construction and Effect Evaluation of the Low Load Blood Flow Restriction Training Program for Lung Cancer Patients Complicated With Sarcopenia During Chemotherapy	NCT06347965	Sarcopenia Lung Neoplasms	Low load blood ... Progressive res...	18 Years -	Zhejiang University
Comparison of AT & PR Training to Improve Functional Ability After Breast Cancer Surgery	NCT05873036	Breast Cancer	Aerobic Trainin... Progressive Res...	35 Years - 65 Years	Superior University
Progressive Resistance Training in Head and Neck Cancer Patients During Concomitant Chemoradiotherapy	NCT02557529	Head and Neck N... Weight Loss	Progressive Res... physical activi... Diet diary	18 Years -	Herlev Hospital
Comparison of AT & PR Training to Improve Functional Ability After Breast Cancer Surgery	NCT05873036	Breast Cancer	Aerobic Trainin... Progressive Res...	35 Years - 65 Years	Superior University
Progressive Resistance Training in Head and Neck Cancer Patients During Concomitant Chemoradiotherapy	NCT02557529	Head and Neck N... Weight Loss	Progressive Res... physical activi... Diet diary	18 Years -	Herlev Hospital
Progressive Resistance Training in Head and Neck Cancer Patients During Concomitant Chemoradiotherapy	NCT02557529	Head and Neck N... Weight Loss	Progressive Res... physical activi... Diet diary	18 Years -	Herlev Hospital

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