Neoplasms

Digestive System Diseases

All Conditions

Colonic Neoplasms

Rectal Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Aerobic exercise at a dose of 225 minutes per week

Moderate- to vigorous-intensity aerobic exercise

Aerobic exercise

Statistic stretching of eight major muscle groups

Progressive stretching

Justin C. Brown, Ph.D.

Justin C Brown, Ph.D.

The goal of this clinical trial is to quantify the effects of aerobic exercise training compared to attention control on intermuscular adipose tissue in colorectal cancer survivors.

Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer

Mean (kg) whole-body intermuscular adipose tissue quantified using magnetic resonance imaging.

National Cancer Institute (NCI)

Pennington Biomedical Research Center

Director, Cancer Metabolism Program

Skin and Connective Tissue Diseases

Breast Neoplasms

Breast Diseases

Skin Diseases

The ultimate goal is for participants to complete approximately 130-180 minutes/week of aerobic training, at 60% to 75 % of the individually determined exercise capacity (VO2peak), for 16 weeks. VO2peak will be determined by the second CPET performed at baseline.

The ultimate goal is for participants to complete approximately 130-180 minutes/week of aerobic training at 55% to 100% of the individually determined exercise capacity (VO2peak), for 16 weeks. VO2peak will be determined by the second CPET performed at Baseline and as well as the CPET performed at Midpoint.

The ultimate goal for the progressive stretching program is 3 to 4 individual stretching sessions/week for 10 to 50 minutes per session (+/- 10 minutes).

The 130-180 minutes/week will be achieved via either 3 to 4 individual aerobic training sessions at approximately 10 to 50 minutes per/session (± 10 minutes).

Linear Aerobic Training

The 130-180 minutes/week will be achieved via 3 to 4 individual aerobic training sessions at approximately 10 to 50 minutes/ per session (+/- 10 minutes).

Nonlinear Aerobic Training

All sessions are required to be supervised. Duration of the stretching sessions is prescribed and implemented in accordance with standard stretching and flexibility training principles. This approach will be applied to guide each participant's prescribed stretching plan, with dose and scheduling modifications made by exercise physiologists, as required.

Progressive Stretching

Cardiopulmonary exercise test (CPET)

Blood draws

Jessica Scott, PhD

The purpose of this study is to compare the effects of 3 different approaches to exercise training in women with early stage breast cancer who have completed all primary treatments (except hormone therapy, if appropriate). Prior research in women with early stage breast cancer has shown that some treatments may have an adverse impact on physical fitness levels leading to feelings of fatigue and poor quality of life. Supervised exercise training has been shown to reduce some of these side-effects. However, all the exercise programs have followed essentially the same approach. This study is designed to see if a different approach to exercise training is more effective than the conventional approach currently in use.

Trial Comparing the Effects of Linear Versus Nonlinear Aerobic Training in Women With Operable Breast Cancer

Exercise Intensity Trial (EXCITE): A Randomized Trial Comparing the Effects of Linear Versus Nonlinear Aerobic Training in Women With Operable Breast Cancer

VO2 or peak oxygen consumption will be measured at 3 time-points. Baseline, mid-point (8 weeks), and post-intervention (16 weeks).

Duke University

Memorial Sloan Kettering Cancer Center

Respiratory Tract (Lung and Bronchial) Diseases

Lung Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

A customized and supervised endurance exercise training program that will last 4 months (16 weeks). The regimen will be tailored to the individual fitness level. The exercise program will consist of three supervised sessions per week. During each session, the participant will cycle on a stationary bicycle at moderate intensity for approximately 30-60 minutes.

A customized and supervised resistance exercise training program that will last 4 months (16 weeks). Resistance training will be performed on stationary weight machines, modification in equipment may be made by Exercise Physiologist. Patients will be progressively trained to perform two to three sets of 75-85% of maximal strength The participant will be trained to perform different resistance exercise, alternating between lower and upper body muscle groups. The exercise program will consist of three supervised sessions per week. Each session will last approximately 30-60 minutes.

A customized and supervised endurance exercise training program that will last 4 months (16 weeks). The regimen will be tailored to the individual fitness level, and will be a combination of Arm A and Arm B, described above. At each session, the participant will complete aerobic training on a stationary bicycle and also resistance training using stationary weight machines. The exercise program will consist of three supervised sessions per week. Each session will last approximately 30-90 minutes.

A customized and supervised progressive stretching program that will last 4 months (16 weeks). The progressive stretching program will consist of a series of stretching exercises alternating between lower and upper body muscle groups/joints. This program will consist of three exercise sessions a week. Each session will last approximately 30-60 minutes.

The overall goal for all the exercise training groups will be 3 supervised exercise sessions per week an intensity between 50 to 100% of the individually determined VO2peak for aerobic training and an intensity between 50% to 85% of 1-RM for resistance training. All the exercise interventions are designed such that participants begin exercising at a low intensity (\~50%-60% VO2peak / 1RM) that is subsequently increased to more moderate to vigorous intensity (\~70%-100% VO2peak / \~70-85% 1RM) when appropriate. All interventions will be individually tailored to each patient following the principles of aerobic or resistance training prescription guidelines for adults.

Exercise Training

The ultimate goal for the progressive stretching program is 3 individual stretching sessions. All sessions are required to be supervised. Duration of the stretching sessions is prescribed and implemented in accordance with standard stretching and flexibility training principles. This approach will be applied to guide each participant's prescribed stretching plan, with dose and scheduling modifications made by exercise physiologists, as required.

Lee Jones, PhD

The purpose of the study is look at the effects of different types of exercise training with a stretching group and its effect on lung cancer patients. Subjects will take part in a 16 week training intervention that can consist of aerobic, resistance, aerobic \& resistance, or a control group. Pre and Post testing will include stress tests, echos, blood, and urine samples.

Lung Cancer Exercise Training Study

Lung Cancer Exercise Training Study: A Randomized Trial of Aerobic Training, Resistance Training, or Both in Lung Cancer Patients

by comparing the efficacy of different types of exercise training modalities in lung cancer following the completion of primary adjuvant therapy.

Herbal and Botanical

All Drugs and Chemicals

Cola

Aerobic exercise at a dose of 75 minutes per week

Aerobic exercise at a dose of 150 minutes per week

Aerobic exercise at a dose of 300 minutes per week

Static stretching of eight major muscle groups

Michelle Ross

Bette J Caan, Dr.P.H.

John Brown

Amalia Perez

Jeffrey A Meyerhardt, M.D.

Jeffrey A. Meyerhardt, M.D., M.P.H.

Bette J. Caan, Dr.P.H.

To goal of this clinical trial is to quantify the dose-response effects of aerobic exercise training compared to attention control on chemotherapy relative dose intensity in colon cancer survivors.

Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer

The ratio of the delivered dose intensity to the standard or planned dose intensity.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer	NCT05789433	Colonic Neoplas... Rectal Neoplasm...	Aerobic exercis... Progressive str...	18 Years -	Pennington Biomedical Research Center
Trial Comparing the Effects of Linear Versus Nonlinear Aerobic Training in Women With Operable Breast Cancer	NCT01186367	Breast Cancer	Linear Aerobic ... Nonlinear Aerob... Progressive Str... Cardiopulmonary... Blood draws	21 Years - 80 Years	Memorial Sloan Kettering Cancer Center
Lung Cancer Exercise Training Study	NCT01068210	Lung Cancer	Exercise Traini... Progressive Str...	21 Years -	Memorial Sloan Kettering Cancer Center
Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer	NCT05773144	Colonic Neoplas...	Aerobic exercis... Progressive str...	18 Years -	Pennington Biomedical Research Center
Trial Comparing the Effects of Linear Versus Nonlinear Aerobic Training in Women With Operable Breast Cancer	NCT01186367	Breast Cancer	Linear Aerobic ... Nonlinear Aerob... Progressive Str... Cardiopulmonary... Blood draws	21 Years - 80 Years	Memorial Sloan Kettering Cancer Center
Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer	NCT05789433	Colonic Neoplas... Rectal Neoplasm...	Aerobic exercis... Progressive str...	18 Years -	Pennington Biomedical Research Center
Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer	NCT05773144	Colonic Neoplas...	Aerobic exercis... Progressive str...	18 Years -	Pennington Biomedical Research Center

Spots Global Cancer Trial Database for progressive stretching