Spots Global Cancer Trial Database for rectal neoplasms

Every month we try and update this database with for rectal neoplasms cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Surviving Rectal Cancer at the Cost of a Colostomy International Validation of the Colostomy Impact Score	NCT03516916	Rectal Neoplasm... Quality of Life Colostomy Stoma	Questionnaires ...	18 Years -	Aarhus University Hospital
Choice of the Optimal Treatment Strategies for Mid-low REctal Cancer	NCT05871762	Rectal Neoplasm...	Registry study,...	-	Peking Union Medical College Hospital
The Role of Transanal Tube Drainage as A Mean of Prevention of Anastomotic Leakage Anastomotic Leakage	NCT03325361	Rectal Cancer Rectal Neoplasm... Anastomotic Lea...	Tube drain inse...	-	University of Rome Tor Vergata
Trial Comparing Loop Ileostomy Versus Loop Transverse Colostomy	NCT05745909	Rectal Neoplasm... Ostomy Neoplasms	Laparoscopic or... Laparoscopic or...	18 Years - 79 Years	Republican Clinical Oncological Dispensary, Ministry of Health of the Republic of Bashkortostan
Total Neoadjuvant Therapy of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer (ENSEMBLE)	NCT05646511	Locally Advance...	SCRT CAPOX CAPOXIRI	18 Years -	National Cancer Center Hospital East
Anastomotic Leakage After Anterior Resection for Rectal Cancer - Predictive Biomarkers and Rectal Blood Flow	NCT02401100	Anastomotic Lea...		-	Umeå University
Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer	NCT05789433	Colonic Neoplas... Rectal Neoplasm...	Aerobic exercis... Progressive str...	18 Years -	Pennington Biomedical Research Center
Oxaliplatin in Rectal Cancer	NCT00259363	Rectal Neoplasm...	Oxaliplatin	18 Years - 80 Years	Sanofi
Neo-Adjuvant FOLFOX for Rectal Carcinoma	NCT00832299	Rectal Neoplasm...	FOLFOX total mesorecta...	18 Years - 70 Years	Beth Israel Medical Center
Safety of a Boost (CXB or EBRT) in Combination With Neoadjuvant Chemoradiotherapy for Early Rectal Adenocarcinoma	NCT02505750	Rectal Neoplasm...	3D conformal EB... Contact X-ray b... Capecitabine	18 Years -	Centre Antoine Lacassagne
Preoperative Chemoradiation With VMAT-SIB in Rectal Cancer	NCT02745639	Rectal Neoplasm...	VMAT-SIB XELOX	18 Years -	IRCCS Azienda Ospedaliero-Universitaria di Bologna
Diverting Loop Ileostomy: With or Without Rod	NCT00959738	Ileostomy Rectal Neoplasm...	Diverting loop ... diverting loop ...	18 Years -	Insel Gruppe AG, University Hospital Bern
Genetic Profile on Predicting Sensibility of Preoperative Chemoradiotherapy on Locally Advanced Rectal Carcinoma	NCT01930942	Rectal Neoplasm...	preoperative co...	18 Years - 75 Years	ChineseAMS
NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery	NCT01056913	Colonic Neoplas... Rectal Neoplasm... Diverticulitis Inflammatory Bo... Rectal Prolapse	Compression Ana... follow-up colon...	18 Years - 90 Years	St John of God Hospital, Vienna
First-Line Bevacizumab and Chemotherapy in Metastatic Cancer of the Colon or Rectum - International Study	NCT00537901	Colonic Neoplas... Rectal Neoplasm...	First-Line Beva... Bevacizumab	-	King Faisal Specialist Hospital & Research Center
Study of Postoperative Concurrent Chemo-radiation With Capecitabine in Elderly Rectal Cancer Patients	NCT01268943	Rectal Neoplasm...	Capecitabine Capecitabine Capecitabine Capecitabine	71 Years -	ChineseAMS
Endoscopic Submucosal Dissection vs Local Laparoscopic Surgical Resection (TAMIS/TEO) in Early Rectal Neoplasias	NCT03959839	Rectal Neoplasm...	ESD TAMIS TEO	18 Years -	Puerta de Hierro University Hospital
Prospective Study Evaluating the Feasibility of Fiducial Markers Placement for Patients With Esophageal or Rectal Cancer	NCT03057288	Esophageal Neop... Rectal Neoplasm...	fiducial marker...	18 Years -	Société Française d'Endoscopie Digestive
Transverse Coloplasty vs. Side-to-end Anastomosis Following Low Anterior Resection (LAR): CSAR Trial	NCT03074461	Rectal Cancer Rectal Neoplasm... Rectal Tumors Fecal Incontine...	Side-to-End Ana... Transverse Colo...	18 Years -	Ludwig-Maximilians - University of Munich
Diverting Loop Ileostomy: With or Without Rod	NCT00959738	Ileostomy Rectal Neoplasm...	Diverting loop ... diverting loop ...	18 Years -	Insel Gruppe AG, University Hospital Bern
THREE-row Circular STAPLER in Low Anterior Resection for Rectal Cancer	NCT03910699	Anastomotic Lea... Anastomotic Hae... Anastomotic Com... Rectal Neoplasm... Staple Misfire Anastomosis Anastomotic Ste...	Three-row circu... Two-row circula...	18 Years - 85 Years	Russian Society of Colorectal Surgeons
XELOX+Bevacizumab Followed by Capecitabine+Bevacizumab+Radiotherapy as Neoadjuvant Treatment of Locally Advanced Rectal Adenocarcinoma	NCT00557713	Rectal Neoplasm... Locally Advance...	bevacizumab	18 Years -	Associacio catalana per a la recerca oncologica i les seves implicacions sanitaries i socials
Pseudo Continent Perineal Colostomy vs Permanent Left Iliac Colostomy After Abdominoperineal Resection for Ultra Low Rectal Adenocarcinoma	NCT04141566	Rectal Neoplasm... Colostomy Stoma Quality of Life	Perineal pseudo... Permanent left ...	18 Years -	Moroccan Society of Surgery
Concentration of Ertapenem in Colorectal Tissue	NCT00535652	Diverticulosis,... Rectal Neoplasm... Colonic Neoplas...	Ertapenem	18 Years - 90 Years	University of Ulm
Trial of Robotic Versus Laparoscopic-assisted Radical Resection for Rectal Cancer	NCT02673177	Rectal Neoplasm...	robot-assisted ... laparoscopic to...	18 Years - 70 Years	Southwest Hospital, China
Robotic Versus Laparoscopic Low Anterior Resection for Rectal Cancer	NCT03209076	Rectal Neoplasm... Sexual Dysfunct... Urinary Inconti... Quality of Life	Robotic Laparoscopic	18 Years - 70 Years	Instituto Nacional de Cancer, Brazil
Organ Preservation in Locally Advanced Rectal Cancer by Radiochemotherapy Followed by Consolidation Chemotherapy.	NCT03561142	Rectal Cancer Rectal Neoplasm... Rectal Cancer S... Rectal Cancer S...	Radiotherapy Chemotherapy Deep regional h...	18 Years -	University Hospital Tuebingen
Irreversible Electroporation(IRE) For Unresectable Rectal Neoplasms	NCT02425059	Rectal Neoplasm...	Irreversible el... NanoKnife	18 Years - 80 Years	Fuda Cancer Hospital, Guangzhou
A Study of Safety and Efficacy of KFA115 Alone and in Combination With Pembrolizumab in Patients With Select Advanced Cancers	NCT05544929	Carcinoma, Non-... Cutaneous Melan... Carcinoma, Rena... Carcinoma, Ovar... Nasopharyngeal ... Carcinoma, Thym... Anal Cancer Mesothelioma Esophagogastric... High Microsatel... Squamous Cell C... Triple Negative...	KFA115 pembrolizumab	18 Years -	Novartis
Application of Circulating Tumor DNA Test in the Diagnosis and Treatment of Patients With Advanced Rectal Cancer	NCT03615170	Rectal Neoplasm... Neoadjuvant The... Circulating Tum...		18 Years - 80 Years	Zhejiang Cancer Hospital
Rectal Sparing Approach After Preoperative Radio and/or Chemotherapy in Patients With Rectal Cancer	NCT02710812	Rectal Neoplasm...	Local Excision ...	18 Years -	University of Padova
Use of One Kind of Controllable Tube Ileostomy in the Low Rectal Cancer	NCT02012023	Rectal Neoplasm... Low Anterior Re...	Low anterior re... tube ileostomy loop ileostomy accept reversal... remove the tube...	-	First Affiliated Hospital of Zhejiang University
Rectal Artery Infusion Chemotherapy Combined With Anti-PD1 Antibody for MSS LARC	NCT05307198	Rectal Neoplasm...	Oxaliplatin Rectectomy Capecitabine Anti-PD-1 monoc...	18 Years - 75 Years	Second Affiliated Hospital, School of Medicine, Zhejiang University
A Study of Ramucirumab or Icrucumab in Colorectal Cancer	NCT01111604	Colon Cancer Rectal Cancer	Ramucirumab Icrucumab mFOLFOX-6	18 Years -	Eli Lilly and Company
Incidence, Risk Factor, Treatment and Overall Survival of Locally Recurrent Rectal Cancer	NCT05475301	Rectal Neoplasm... Neoplasm Recurr...		18 Years -	Radboud University Medical Center
Study of Postoperative Concurrent Chemo-radiation With Capecitabine in Elderly Rectal Cancer Patients	NCT01268943	Rectal Neoplasm...	Capecitabine Capecitabine Capecitabine Capecitabine	71 Years -	ChineseAMS
Transanal Endoscopic Microsurgery Versus Endoscopic Submucosal Dissection For Large Rectal Adenomas	NCT01023984	RECTAL NEOPLASM...	TEM - Transanal... ESD - Endoscopi...	18 Years -	European Association for Endoscopic Surgery
Prediction of Response to Neoadjuvant Therapy in Rectal Cancer	NCT02439086	Rectal Neoplasm...	PET-CT Scan	-	Colchester General Hospital
Predictive Factors of Disease-free Survival After Complete Pathological Response to Neoadjuvant Radiotherapy in Rectal Adenocarcinoma	NCT03601689	Rectal Neoplasm...	rectal resectio...	18 Years -	Moroccan Society of Surgery
Safety and Feasibility of PD-1 Blockade in the Treatment of dMMR or MSI-H Rectal Cancer	NCT04357587	Rectal Neoplasm...	Pembrolizumab External beam r... Capecitabine	18 Years -	Case Comprehensive Cancer Center
Predicting Neoadjuvant Therapy Response of Rectal Cancer With MRI	NCT02640586	Rectal Neoplasm...	three MR examin...	18 Years -	Peking University Cancer Hospital & Institute
An Extended Feasibility Phase I/II Study of Methylenetetrahydrofolate (Arfolitixorin) and Pemetrexed Single Agent, Given as Neoadjuvant Treatment in Patients With Resectable Rectal Cancer	NCT01397305	Rectal Cancer	[6R] 5,10-methy... Pemetrexed	18 Years -	Isofol Medical AB
A Study of LY2880070 in Participants With Advanced or Metastatic Cancer	NCT02632448	Solid Tumors Colorectal Canc... Breast Cancer Ovarian Cancer Colon Cancer Rectal Cancer Neoplasms Endometrial Can... Soft Tissue Sar... Triple Negative... Pancreas Cancer Pancreatic Canc...	LY2880070 Gemcitabine	18 Years -	Esperas Pharma Inc.
Fish Oil Supplement in Rectal Cancer	NCT02534389	Rectal Neoplasm...	omega-3 fish oi...	18 Years -	AC Camargo Cancer Center
Adjuvant Treatment of Concurrent RT and CAPOX or Capecitabine Alone for Stage II and III Rectal Cancer	NCT00714077	Rectal Neoplasm...		18 Years - 75 Years	ChineseAMS
A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer	NCT05009069	Rectal Neoplasm... Rectal Cancer	Radiotherapy Capecitabine Fluorouracil Atezolizumab Tiragolumab	18 Years -	Hoffmann-La Roche
Anterior Perineal Plane for Ultra Low Anterior Resection of the Rectum	NCT00534131	Rectal Neoplasm... Colitis, Ischem... Colitis, Ulcera...	Standard abdomi... APPEAR Procedur... Proctectomy	16 Years -	Queen Mary University of London
Diverting Loop Ileostomy: With or Without Rod	NCT00959738	Ileostomy Rectal Neoplasm...	Diverting loop ... diverting loop ...	18 Years -	Insel Gruppe AG, University Hospital Bern
Organ Preservation in Locally Advanced Rectal Cancer by Radiochemotherapy Followed by Consolidation Chemotherapy.	NCT03561142	Rectal Cancer Rectal Neoplasm... Rectal Cancer S... Rectal Cancer S...	Radiotherapy Chemotherapy Deep regional h...	18 Years -	University Hospital Tuebingen
Predicting RadIotherapy ReSponse of Rectal Cancer With MRI and PET	NCT02233374	Rectal Neoplasm...	Early MRI and P... Late MRI and PE...	18 Years -	Royal North Shore Hospital
Endoscopic Posterior Mesorectal Resection in T1 Rectal Cancer	NCT00531297	Rectal Neoplasm...	endoscopic post...	18 Years -	Cantonal Hospital of St. Gallen
Organ Preservation With Tislelizumab and Total Neoadjuvant Therapy in Patients With Low Rectal Cancer: RELIEVE -01 Study	NCT06390982	RECTAL NEOPLASM... Rectal Cancer	Radiotherapy Tislelizumab Capecitabine Oxaliplatin Capecitabine	18 Years - 75 Years	Fudan University
A Trial of Durvalumab (MEDI 4736) in Combination With Extended Neoadjuvant Regimens in Rectal Cancer	NCT04621370	Rectal Cancer Rectal Adenocar... Rectal Neoplasm...	Durvalumab FOLFOX Short Course Ra... Long course che... Capecitabine	18 Years -	Cancer Research UK, Glasgow
Neoadjuvant Arterial Embolization Chemotherapy Combined PD-1 Inhibitor for Locally Advanced Rectal Cancer	NCT05420584	Rectal Neoplasm...	Arterial chemoe... Tislelizumab In... XELOX Pelvic MRI Laparoscopic ra...	18 Years - 75 Years	The Fourth Affiliated Hospital of Zhejiang University School of Medicine
A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer	NCT05009069	Rectal Neoplasm... Rectal Cancer	Radiotherapy Capecitabine Fluorouracil Atezolizumab Tiragolumab	18 Years -	Hoffmann-La Roche
Shear Wave Elastography of Rectal Adenomas and Cancer	NCT04409990	Rectal Neoplasm... Elasticity Imag...	Shear Wave Elas...	-	Vejle Hospital
Local Excision of Clinical T3 Rectal Adenocarcinoma Showing Major Response(ycT0-1) After Neoadjuvant Chemoradiotherapy	NCT02490709	Rectal Cancer	Local excision	20 Years -	National Cancer Center, Korea
MRI Simulation-guided Boost in Short-course Preoperative Radiotherapy for Unresectable Rectal Cancer	NCT03714490	Rectal Neoplasm...	SCPRT CRT CAPOX	18 Years - 70 Years	Cancer Institute and Hospital, Chinese Academy of Medical Sciences
No Stoma VS Ghost Stoma in Patients Undergoing Total Mesorectal Excision for Rectal Cancer	NCT06225609	Rectal Neoplasm...	Ghost ileostomy No ileostomy	18 Years - 80 Years	Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Mri IN STaging REctal Polyp Planes	NCT02532803	Rectal Cancer Rectal Neoplasm... Colonic Polyps	Novel Pelvic MR...	18 Years -	Royal Marsden NHS Foundation Trust
"Wait-and-see" Policy for Complete Responders After Chemoradiotherapy for Rectal Cancer	NCT03426397	Rectal Neoplasm...		18 Years -	The Netherlands Cancer Institute
Robotic Transanal Specimen Extraction Surgery Versus Robotic Transabdominal Incision Specimen Extraction Surgery for Patients With Rectal Cancer: A Multicenter Randomized Controlled Trial	NCT05468944	Rectal Neoplasm... Robotic Surgery Natural Orifice...	Transanal speci... Transabdominal ...	18 Years - 75 Years	The First Affiliated Hospital of Nanchang University
Diagnostic Value of Novel MR Imaging Techniques for the Primary Staging and Restaging of Rectal Cancer	NCT01721785	Rectal Neoplasm... Magnetic Resona... Neoplasms Stagi...	GADOFOSVESET TR...	18 Years -	Maastricht University Medical Center
Mesorectal Microbiome as a Prognostic Factor in Patients With Rectal Cancer	NCT04804956	Rectal Cancer	Stool sample Rectal mucosa s... Mesorectal adip... Subcutaneous ad... Visceral adipos... Dietary assessm...	18 Years - 18 Years	University Hospital of Girona Dr.Josep Trueta
Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer	NCT05297734	End of Life Cancer	Receive technol... Receive redesig...	21 Years -	Stanford University
RATME vs LATME in Middle and Low Rectal Cancer	NCT06105203	Total Mesorecta... Rectal Neoplasm... Robotic Surgica... Laparoscopy	Robotic-assiste... laparoscopic-as...	18 Years - 75 Years	The First Hospital of Jilin University
Incidence, Risk Factor, Treatment and Overall Survival of Locally Recurrent Rectal Cancer	NCT05475301	Rectal Neoplasm... Neoplasm Recurr...		18 Years -	Radboud University Medical Center
Rectrospect - a Retrospective Study of Treatment Response	NCT04787523	Rectal Neoplasm...	Radiotherapy	-	Sahlgrenska University Hospital, Sweden
First-Line Bevacizumab and Chemotherapy in Metastatic Cancer of the Colon or Rectum - International Study	NCT00537901	Colonic Neoplas... Rectal Neoplasm...	First-Line Beva... Bevacizumab	-	King Faisal Specialist Hospital & Research Center
The Safety and Efficiency of Stent-based Diverting Technique Versus Ileostomy in Rectal Cancer Patients	NCT06204497	Rectal Neoplasm...	Stent-based Div...	18 Years - 80 Years	Sir Run Run Shaw Hospital
Endoscopic Submucosal Dissection vs Local Laparoscopic Surgical Resection (TAMIS/TEO) in Early Rectal Neoplasias	NCT03959839	Rectal Neoplasm...	ESD TAMIS TEO	18 Years -	Puerta de Hierro University Hospital
SGM-101 in Colorectal Brain Metastases.	NCT04755920	Rectal Neoplasm... Rectum Cancer Colorectal Neop... Brain Metastase... Brain Neoplasms Brain Diseases Brain Cancer Brain Tumor Intestinal Neop... Gastrointestina... Gastrointestina... Gastrointestina... Intestinal Dise...	SGM-101	18 Years -	Leiden University Medical Center
Audit of Surgery for Colorectal Cancer	NCT04349384	Rectal Adenocar... Colon Adenocarc...	Colorectal rese...	18 Years -	Institut National d'Oncologie, Morocco
Symptoms and Quality of Life (QoL) After Palliative Pelvic Radiation of Prostate and Rectal Cancers	NCT01023529	Prostatic Neopl... Rectal Neoplasm...	Palliative pelv...	18 Years -	Sorlandet Hospital HF
Surviving Rectal Cancer at the Cost of a Colostomy International Validation of the Colostomy Impact Score	NCT03516916	Rectal Neoplasm... Quality of Life Colostomy Stoma	Questionnaires ...	18 Years -	Aarhus University Hospital
Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal Cancer	NCT05943444	Rectal Neoplasm... Low Anterior Re... Anastomotic Lea... Quality of Life	Parks technique Bacon technique	18 Years - 75 Years	Sixth Affiliated Hospital, Sun Yat-sen University
Gene Expression and FDG PET/MRI in Evaluating Treatment Response in Patients With Locally Advanced Rectal Cancer Undergoing Chemotherapy and Radiation Therapy Before Surgery	NCT02112162	Rectal Neoplasm...	fludeoxyglucose... positron emissi... magnetic resona... laboratory biom...	18 Years -	Washington University School of Medicine
Perfusion Outcomes With Near Infrared-Indocyanine Green Imaging System in Laparoscopic Total Mesorectal Excision for Mid- or Low-rectal CanceR	NCT04012645	Rectal Neoplasm...	application of ... Non-application...	18 Years - 80 Years	Beijing Friendship Hospital
A Trial of Dalotuzumab in Combination With Irinotecan Versus Cetuximab and Irinotecan for Participants With Metastatic Rectal Cancers (mRC) (MK-0646-025)	NCT01609231	Rectal Neoplasm...	Dalotuzumab Irinotecan Cetuximab	18 Years -	Merck Sharp & Dohme LLC
Exercise Training for Rectal Cancer Patients	NCT02538913	Rectal Neoplasm...	Exercise traini... Usual care	18 Years - 80 Years	Norwegian University of Science and Technology

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