Neoplasms

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Head and Neck Neoplasms

Single session of 4 intratumoral injections consisting of 0.1-0.3 ml radioactive Holmium-166 microsphere suspension with a total activity 30 Megabecquerel, 7-12 days prior to surgical resection.

Intratumoral injections of Holmium-166 (poly L lactic acid) microspheres

Holmium-166 (poly L lactic acid) microspheres

Marnix G Lam, MD, PhD

The main objective is to establish the feasibility of 166-Holmium microspheres for intratumoral injections in oral squamous cell carcinoma (OSCC) of the tongue.

Participants will receive intratumoral injections with a low radioactive 166-Holmium microspheres followed by surgical resection

166-Holmium microspheres poly lactic acid microspheres are currently used in selective internal radiation therapy. These microspheres emits beta radiation. The majority of the radiation dose will be absorbed within 3.2 mm with a maximum penetration in tissue of 9 mm. Therefore this can result in a high local tumor ablative dose with minimal dose to healthy adjacent tissue.

Feasibility of Holmium-166 Micro Brachytherapy in Head and Neck Tumors

Feasibility of Holmium-166 Microspheres for Selective Intra-tumoural Treatment in Head and Neck Cancer: Biodistribution and Safety in Patients With Malignancy of the Tongue

SPECT Thorax and Abdomen Radioactivity in a blood and urine sample

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Feasibility of Holmium-166 Micro Brachytherapy in Head and Neck Tumors	NCT02975739	Radioisotopes Head and Neck N...	Holmium-166 (po...	18 Years -	UMC Utrecht
Feasibility of Holmium-166 Micro Brachytherapy in Head and Neck Tumors	NCT02975739	Radioisotopes Head and Neck N...	Holmium-166 (po...	18 Years -	UMC Utrecht

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