Neoplasms

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Symptoms and General Pathology

Diseases and Abnormalities at or Before Birth

Rare Diseases

Carcinoma

Carcinoma, Renal Cell

Ischemia

Congenital Abnormalities

Urologic Neoplasms

Kidney Neoplasms

Adenocarcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Urogenital Neoplasms

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Kidney Diseases

Urologic Diseases

Male Urogenital Diseases

Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Saban Sarıkaya, Professor

Ender Ozden, Professor

The aim of the study is to evaluate trifecta and pentafecta outcomes for laparoscopic partial nephrectomy (LNP) in patients with clinical T1N0M0 renal tumor.

From November 2009 to August 2018 a total of 292 patients who underwent LPN by global ischemia were included in the study. The patients were allocated into two groups according to the tumor size; T1a (≤ 40 mm, n=215), T1b (41-70 mm, n=77). Demographics features, clinical tumor characteristics, intraoperative and postoperative outcomes were analyzed. A negative surgical margin, warm ischemia time (WIT) \< 20 min and no postoperative complications (Clavien-Dindo ≥ grade 3) were accepted to achieve the trifecta outcomes. Pentafecta has defined as trifecta criteria plus \>90% preservation of estimated glomerular filtration rate (eGFR) and no stage upgrade of chronic kidney disease 12 months after LPN. Univariable and multivariable analysis were used to identify factors predicting trifecta and pentafecta achievement.

Laparoscopic Partial Nephrectomy for cT1 Tumors

Evaluation Trifecta and Pentafecta Outcomes of Patients Underwent Laparoscopic Partial Nephrectomy for cT1 Renal Tumor

It is not yet known if there will be a plan to make IPD available.

The clamp time of the renal artery and vein which is required to complete tumor excision and renorrhaphy

abnormal problmes that may be seen during surgery

abnormal problmes that may be seen after surgery and require additional intervention, treatment or follow-up

serum creatinine level and estimated glomerular filtration rate

presence or absence of tumors at the surgical margin

Comparison of preoperative and postoperative renal functions according to numerical and percentile values

evaluation of preoperative and postoperative renal functions according to chronic kidney disease stages

Presence or absence of local and/or distal tumor recurrence

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Laparoscopic Partial Nephrectomy for cT1 Tumors	NCT04213157	Renal Cancer Renal Neoplasm Renal Cell Carc... Surgery Surgery--Compli... Renal Functiona... Oncology Oncology Proble... Kidney Ischemia Kidney Injury Urologic Neopla... Urologic Cancer Kidney Neoplasm...		18 Years - 82 Years	Samsun Liv Hospital
Laparoscopic Partial Nephrectomy for cT1 Tumors	NCT04213157	Renal Cancer Renal Neoplasm Renal Cell Carc... Surgery Surgery--Compli... Renal Functiona... Oncology Oncology Proble... Kidney Ischemia Kidney Injury Urologic Neopla... Urologic Cancer Kidney Neoplasm...		18 Years - 82 Years	Samsun Liv Hospital

Spots Global Cancer Trial Database for renal functional abnormality