Neoplasms

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Rare Diseases

Carcinoma

Carcinoma, Renal Cell

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Adenocarcinoma

Kidney Neoplasms

Urologic Neoplasms

Urogenital Neoplasms

Urogenital Diseases

Female Urogenital Diseases

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Female Urogenital Diseases and Pregnancy Complications

Kidney Diseases

Urologic Diseases

Male Urogenital Diseases

Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

These participants with clinical T1 renal cell carcinoma(RCC) undergo precise segmental renal arterial clamping during laparoscopic partial nephrectomy.

These participants with clinical T1 renal cell carcinoma(RCC) undergo complete renal arterial clamping during laparoscopic partial nephrectomy.

Precise segmental renal artery clamping eliminates global renal ischemia by performing highly selective clamping of single or multiple segmental arteries.

precise segmental renal arterial clamping

Laparoscopic partial nephrectomy (LPN) has been widely adopted as a minimally invasive nephron-sparing surgery for clinical T1 renal cell carcinoma(RCC).

laparoscopic partial nephrectomy

Zhenhua Shang, MD.

Hao Yan

Zhenhua Shang

Tongwen Ou, MD.

Renal functional reserve may be better in patients with clinical T1 renal cell carcinoma(RCC) undergoing laparoscopic partial nephrectomy with precise segmental renal artery clamping than those with complete renal arterial clamping.

Renal functional reserve (RFR) describes the capacity of the intact nephron mass to increase glomerular filtration rate(GFR) from baseline in response to stimuli (e.g., protein load).We hypothesized that renal functional reserve may be better in patients with clinical T1 renal cell carcinoma(RCC) undergoing laparoscopic partial(LPN) nephrectomy with precise segmental renal artery clamping than those with complete renal arterial clamping.

Some participants with clinical T1 renal cell carcinoma(RCC) undergo precise segmental during laparoscopic partial nephrectomy and the others undergo complete renal arterial clamping.

RFR Change of Precise Segmental Versus Complete Renal Arterial Clamping During LPN for Clinical T1 RCC

Renal Functional Reserve Change of Precise Segmental Versus Complete Renal Arterial Clamping During Laparoscopic Partial Nephrectomy for Clinical T1 Renal Cell Carcinoma

Change in renal functional reserve after laparoscopic partial nephrectomy

Xuanwu Hospital, Beijing

chairman of urology

Symptoms and General Pathology

Cysts

Kidney Diseases, Cystic

Pathological Conditions, Anatomical

participants are with endophytic renal cyst and undergo laparoscopic deroofing.2 day before laparoscopic deroofing, they were given intravenous 100 g of amino acids supplementation.

participants are with exophytic renal cyst and undergo laparoscopic deroofing.2 day before laparoscopic deroofing, they were given intravenous 100 g of amino acids supplementation.

The classic treatment of patients with simple renal cysts is deroofing, which can be performed by open surgery or laparoscopy. Laparoscopic deroofing is an effective minimally invasive approach and has gained popularity.

Laparoscopic deroofing

intravenous supplementation with 100 g of amino acids 2 day before laparoscopic deroofing.

100 g of amino acids supplementation

Hao Yan, MD.

Renal functional reserve may be improved in patients with simple renal cysts after laparoscopic deroofing.

Simple renal cysts (SRC) are the most frequent type of cystic renal disease. The prevalence rate of SRCs is about 10% and increases with age. Hypertension and decreased renal functions have been reported to occur more commonly among these patients with SRC and there are no clear guidelines for managing asymptomatic SRCs.Renal functional reserve (RFR) describes the capacity of the intact nephron mass to increase glomerular filtration rate(GFR) from baseline in response to stimuli (e.g., protein load).The investigators hypothesized that RFR may be improved in some patients with simple renal cysts after laparoscopic deroofing despite identical resting glomerular filtration rate (rGFR).The aim of this study is to examine whether there is improvement of RFR in patients with simple renal cysts after laparoscopic deroofing.

Participants are assigned to two groups.One group participants are with endophytic simple renal cysts, and the other are with exophytic simple renal cysts.

Measurement of Renal Functional Reserve Change In Patients With SRC Before and After Laparoscopic Deroofing

Measurement of Renal Functional Reserve Change In Patients With Simple Renal Cysts Before and After Laparoscopic Deroofing

1 month after surgery, repeated glomerular filtration rate measurements are to be performed to calculate change in renal functional reserve.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
RFR Change of Precise Segmental Versus Complete Renal Arterial Clamping During LPN for Clinical T1 RCC	NCT03259477	Renal Cell Carc...	precise segment... laparoscopic pa...	18 Years - 90 Years	Xuanwu Hospital, Beijing
Measurement of Renal Functional Reserve Change In Patients With SRC Before and After Laparoscopic Deroofing	NCT03259594	Simple Renal Cy...	Laparoscopic de... 100 g of amino ...	18 Years - 90 Years	Xuanwu Hospital, Beijing
Measurement of Renal Functional Reserve Change In Patients With SRC Before and After Laparoscopic Deroofing	NCT03259594	Simple Renal Cy...	Laparoscopic de... 100 g of amino ...	18 Years - 90 Years	Xuanwu Hospital, Beijing

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