Neoplasms

All Conditions

Symptoms and General Pathology

Rare Diseases

Carcinoma

Carcinoma, Squamous Cell

Neoplasm, Residual

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Neoplasms, Squamous Cell

Neoplastic Processes

Oral Squamous Cell Carcinoma

biological assessment on operating bed to detect residual circulating tumor DNA

Circulating tumor DNA detection

Lise-Marie Roussel, MD

Doriane Richard, PhD

Sophie Deneuve, Md

Lise-Marie Roussel, Md

The aim of this study is to evaluate the interest of residual tumour DNA research in the operating bed after squamous cell carcinoma excision.

Squamous cell carcinomas of the oral cavity have a poor prognosis. The 5-year loco-regional recurrence rate is 45%. Surgery remains the standard treatment. The presence of invasive or insufficient surgical margins is an important histopronostic factor.

Current tools for intraoperative detection of insufficient margins have a very low sensitivity of around 10%. The aim here is to develop a more sensitive tool by looking for the presence of residual tumour DNA in the entire operating bed after squamous cell carcinoma excision

Contribution of Residual Tumour DNA Testing on the Surgical Bed

Contribution of Residual Tumour DNA Testing on the Surgical Bed of Squamous Cell Carcinomas of the Oral Cavity

Proportion of patients with residual tumour DNA on the operating bed according to the presence or absence of adverse histological factors

Proportion of patients with circulating tumour DNA and in the cervical lymphatic drainage fluid or circulating blood according to the presence or absence of residual tumour DNA on the operating bed

Centre Henri Becquerel

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Contribution of Residual Tumour DNA Testing on the Surgical Bed	NCT05934929	Squamous Cell C...	Circulating tum...	18 Years -	Centre Henri Becquerel
Contribution of Residual Tumour DNA Testing on the Surgical Bed	NCT05934929	Squamous Cell C...	Circulating tum...	18 Years -	Centre Henri Becquerel

Spots Global Cancer Trial Database for residual tumor dna