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Brief Title: Contribution of Residual Tumour DNA Testing on the Surgical Bed
Official Title: Contribution of Residual Tumour DNA Testing on the Surgical Bed of Squamous Cell Carcinomas of the Oral Cavity
Study ID: NCT05934929
Brief Summary: The aim of this study is to evaluate the interest of residual tumour DNA research in the operating bed after squamous cell carcinoma excision.
Detailed Description: Squamous cell carcinomas of the oral cavity have a poor prognosis. The 5-year loco-regional recurrence rate is 45%. Surgery remains the standard treatment. The presence of invasive or insufficient surgical margins is an important histopronostic factor. Current tools for intraoperative detection of insufficient margins have a very low sensitivity of around 10%. The aim here is to develop a more sensitive tool by looking for the presence of residual tumour DNA in the entire operating bed after squamous cell carcinoma excision
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
CHU Rouen, Rouen, , France
Centre Henri Becquerel, Rouen, , France
Name: Lise-Marie Roussel, MD
Affiliation: Centre Henri Becquerel
Role: PRINCIPAL_INVESTIGATOR