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Spots Global Cancer Trial Database for Contribution of Residual Tumour DNA Testing on the Surgical Bed

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Trial Identification

Brief Title: Contribution of Residual Tumour DNA Testing on the Surgical Bed

Official Title: Contribution of Residual Tumour DNA Testing on the Surgical Bed of Squamous Cell Carcinomas of the Oral Cavity

Study ID: NCT05934929

Study Description

Brief Summary: The aim of this study is to evaluate the interest of residual tumour DNA research in the operating bed after squamous cell carcinoma excision.

Detailed Description: Squamous cell carcinomas of the oral cavity have a poor prognosis. The 5-year loco-regional recurrence rate is 45%. Surgery remains the standard treatment. The presence of invasive or insufficient surgical margins is an important histopronostic factor. Current tools for intraoperative detection of insufficient margins have a very low sensitivity of around 10%. The aim here is to develop a more sensitive tool by looking for the presence of residual tumour DNA in the entire operating bed after squamous cell carcinoma excision

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

CHU Rouen, Rouen, , France

Centre Henri Becquerel, Rouen, , France

Contact Details

Name: Lise-Marie Roussel, MD

Affiliation: Centre Henri Becquerel

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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