Spots Global Cancer Trial Database for Contribution of Residual Tumour DNA Testing on the Surgical Bed

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Contribution of Residual Tumour DNA Testing on the Surgical Bed

Official Title: Contribution of Residual Tumour DNA Testing on the Surgical Bed of Squamous Cell Carcinomas of the Oral Cavity

Study ID: NCT05934929

Conditions

Squamous Cell Carcinoma of the Oral Cavity

Interventions

Circulating tumor DNA detection

Study Description

Brief Summary: The aim of this study is to evaluate the interest of residual tumour DNA research in the operating bed after squamous cell carcinoma excision.

Detailed Description: Squamous cell carcinomas of the oral cavity have a poor prognosis. The 5-year loco-regional recurrence rate is 45%. Surgery remains the standard treatment. The presence of invasive or insufficient surgical margins is an important histopronostic factor. Current tools for intraoperative detection of insufficient margins have a very low sensitivity of around 10%. The aim here is to develop a more sensitive tool by looking for the presence of residual tumour DNA in the entire operating bed after squamous cell carcinoma excision