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Surgical resection combined with intraperitoneal hyperthermic perfusion chemotherapy

（1）Partial hepatectomy: The reasonable resection method was selected according to the tumor location, residual liver volume and the operation process. The tumor margin should be more than 1 cm, the abdominal cavity was flushed with sterile warm distilled water. In the control group,1-2 abdominal drainage tubes were placed on the hepatic cross-section, in the exposed group,4 abdominal perfusion tubes were placed in the right hepatic apex, splenic fossa, left and right pelvic cavity to perform HIPEC postoperatively.

(2) HIPEC: Temperature setting:43 °C perfusion time:60 min, perfusion speed:400-600 mL/min ,perfusion volume:3000 mL.

（3）Hepatic artery embolization：Through the common femoral artery, the catheter passed through the abdominal aorta, celiac trunk, the common hepatic artery and the inherent hepatic artery to the blood supply target artery of liver cancer. The embolic agent Lipiodol was mixed and injected to embolize the bleeding artery to stop bleeding.

intraperitoneal hyperthermic perfusion chemotherapy

Mingxin Pan, Prof.

Patients with ruptured liver cancer and bleeding after surgical resection were included according to the criteria of admission, and the patients were divided into experimental and control groups. the primary efficacy end point was RFS, and the secondary end point was the rate of abdominal implant metastases and OS.To analyze the efficacy of HIPEC.

Patients with ruptured liver cancer and bleeding after surgical resection were included according to the criteria of admission, and the patients were divided into groups: experimental group: surgical resection combined with intraperitoneal hyperthermic perfusion chemotherapy, and control group: simple surgical resection.

At further follow-up, the primary efficacy end point was time to Recurrence free survival (RFS) ,the time from the patient's treatment until the discovery of abdominal metastases or until the follow-up period, and the secondary end point was the rate of abdominal implant metastases, that is, according to the postoperative follow-up test and imaging findings, the incidence of abdominal implantation and metastasis, until the end of abdominal recurrence or metastasis or observation period. Overall Survival OS and survival rate: the time from the time the patient underwent partial hepatectomy until death from tumor causes or the end of the observation period. To analyze the efficacy of HIPEC.

Surgical Resection Combined With Intraperitoneal Hyperthermic Chemotherapy

A Retrospective Study of Surgical Resection Combined With Intraperitoneal Hyperthermic Chemotherapy in the Treatment of Ruptured Hepatocellular Carcinoma

Intra-abdominal recurrence-free survival (RFS):the time from surgical resection patients with HCC until the detection of intra-abdominal recurrence or metastasis or the end of the observation period, based on postoperative follow-up test criteria and imaging findings(2 years)

Overall Survival (OS): time from partial hepatectomy for HCC until death from any cause or end of observation period(2 years)

defined as 1-month,3-month,6-month, 1-year,2-year survival rate

Zhujiang Hospital

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Surgical Resection Combined With Intraperitoneal Hyperthermic Chemotherapy	NCT06247293	Hyperthermic In... Hepatocellular ... Ruptured Liver	intraperitoneal...	18 Years - 80 Years	Zhujiang Hospital
Surgical Resection Combined With Intraperitoneal Hyperthermic Chemotherapy	NCT06247293	Hyperthermic In... Hepatocellular ... Ruptured Liver	intraperitoneal...	18 Years - 80 Years	Zhujiang Hospital

Spots Global Cancer Trial Database for ruptured liver