Symptoms and General Pathology

All Conditions

Skin and Connective Tissue Diseases

Neoplasms

Diseases and Abnormalities at or Before Birth

Cicatrix

Acne Vulgaris

Hyperplasia

Hemangioma, Capillary

Port-Wine Stain

Nevus, Pigmented

Sebaceous Gland Diseases

Hypertrichosis

Nevus

Nevus of Ota

Hemangioma

Congenital Abnormalities

Skin Abnormalities

Skin Diseases

Neoplasms, Vascular Tissue

Neoplasms by Histologic Type

Hair Diseases

Melanoma

Nevi and Melanomas

Optical Clearing

Kristen M Kelly, M.D

The research hypothesis is that topical application of a mixture of pre-polymers of polypropylene glycol and polyethylene glycol (an optical clearing agent) will reduce skin light scattering, increasing the amount of light reaching the target for diagnostic as well as therapeutic purposes.

The researchers expect that application of the optical clearing agent for treatment of benign vascular lesions, tattoos, nevus of Ota, hypertrichosis, scars, acne and sebaceous hyperplasia will result in

1. decreased reflectance of the predominant color from the surface of skin (decreased red light scattering in case of benign vascular lesions, etc) as compared to the control group.
2. greater Optical Coherence Tomography a non-invasive light based imaging method imaging depth as compared to the control group.
3. greater improvement in the treatment outcome (decrease in the erythema index following laser treatment of vascular lesions as compared to the laser alone group; improved lightening of the tattoo or nevus of Ota as compared to the laser treatment alone group; significant decrease in hair re-growth as compared to laser treatment alone in patients seeking hair removal; greater improvement of scars, acne and sebaceous hyperplasia).

Optical Clearing of the Skin in Conjunction With Laser Treatments

Beckman Laser Institute University of California Irvine

University of California, Irvine

Kristen Kelly, M.D., Professor Departments of Dermatology and Surgery

Wounds and Injuries

Necrosis

Burns

Skin Neoplasms

Soft Tissue Injuries

Autologous tissue-engineered dermal substitute

Autologous tissue-engineered dermo-epidermal skin substitute

Transplantation of an autologous tissue-engineered dermal substitute, covered with autologous split-thickness skin

denovoDerm

Transplantation of autologous tissue-engineered dermo-epidermal skin substitute, no additional coverage needed

denovoSkin

Sophie Böttcher, PD Dr. med.

The purpose of this study is the evaluation of the safety of autologous tissue-engineered dermal substitutes "denovoDerm" (first arm) and dermo-epidermal skin substitutes "denovoSkin" (second arm) transplanted onto the wound bed in children and adults.

Phase I Study for Autologous Dermal Substitutes and Dermo-epidermal Skin Substitutes for Treatment of Skin Defects

A Phase I, Two Armed, Open, Prospective and Multicentre Study to Evaluate the Safety of Autologous Tissue-engineered Dermal Substitutes and Dermo-epidermal Skin Substitutes for the Treatment of Large Deep Partial and Full Thickness Skin Defects in Children and Adults

Assessment/reporting of local infection rate and graft take

Assessment/reporting of number of adverse events

University Hospital, Zürich

University of Zurich

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Optical Clearing of the Skin in Conjunction With Laser Treatments	NCT00580736	Port Wine Stain Nevus of Ota Tattoos Scars Acne Hypertrichosis Sebaceous Gland...	Optical Clearin...	18 Years -	University of California, Irvine
Phase I Study for Autologous Dermal Substitutes and Dermo-epidermal Skin Substitutes for Treatment of Skin Defects	NCT02145130	Burn Injury Soft Tissue Inj... Skin Necrosis Scars Congenital Gian... Skin Tumors	denovoDerm denovoSkin	1 Year - 70 Years	University of Zurich
Optical Clearing of the Skin in Conjunction With Laser Treatments	NCT00580736	Port Wine Stain Nevus of Ota Tattoos Scars Acne Hypertrichosis Sebaceous Gland...	Optical Clearin...	18 Years -	University of California, Irvine
Phase I Study for Autologous Dermal Substitutes and Dermo-epidermal Skin Substitutes for Treatment of Skin Defects	NCT02145130	Burn Injury Soft Tissue Inj... Skin Necrosis Scars Congenital Gian... Skin Tumors	denovoDerm denovoSkin	1 Year - 70 Years	University of Zurich

Spots Global Cancer Trial Database for scars

Every month we try and update this database with for scars cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for scars

Every month we try and update this database with for scars cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for scars cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.