Symptoms and General Pathology

All Conditions

Skin and Connective Tissue Diseases

Neoplasms

Diseases and Abnormalities at or Before Birth

Cicatrix

Acne Vulgaris

Hyperplasia

Hemangioma, Capillary

Port-Wine Stain

Nevus, Pigmented

Sebaceous Gland Diseases

Hypertrichosis

Nevus

Nevus of Ota

Hemangioma

Congenital Abnormalities

Skin Abnormalities

Skin Diseases

Neoplasms, Vascular Tissue

Neoplasms by Histologic Type

Hair Diseases

Melanoma

Nevi and Melanomas

Optical Clearing

Kristen M Kelly, M.D

The research hypothesis is that topical application of a mixture of pre-polymers of polypropylene glycol and polyethylene glycol (an optical clearing agent) will reduce skin light scattering, increasing the amount of light reaching the target for diagnostic as well as therapeutic purposes.

The researchers expect that application of the optical clearing agent for treatment of benign vascular lesions, tattoos, nevus of Ota, hypertrichosis, scars, acne and sebaceous hyperplasia will result in

1. decreased reflectance of the predominant color from the surface of skin (decreased red light scattering in case of benign vascular lesions, etc) as compared to the control group.
2. greater Optical Coherence Tomography a non-invasive light based imaging method imaging depth as compared to the control group.
3. greater improvement in the treatment outcome (decrease in the erythema index following laser treatment of vascular lesions as compared to the laser alone group; improved lightening of the tattoo or nevus of Ota as compared to the laser treatment alone group; significant decrease in hair re-growth as compared to laser treatment alone in patients seeking hair removal; greater improvement of scars, acne and sebaceous hyperplasia).

Optical Clearing of the Skin in Conjunction With Laser Treatments

Beckman Laser Institute University of California Irvine

University of California, Irvine

Kristen Kelly, M.D., Professor Departments of Dermatology and Surgery

Wounds and Injuries

Infections

Rare Diseases

Carcinoma

Carcinoma, Squamous Cell

Scleroderma, Systemic

Scleroderma, Diffuse

Keratosis, Actinic

Keratosis

Burns

Carcinoma, Basal Cell

Sarcoma

Keratosis, Seborrheic

Histiocytoma

Sarcoma, Kaposi

Carcinoma, Merkel Cell

Histiocytoma, Benign Fibrous

Neoplasms, Glandular and Epithelial

Neuroendocrine Tumors

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms, Nerve Tissue

Skin Neoplasms

Neoplasms, Connective and Soft Tissue

Neoplasms, Basal Cell

Communicable Diseases

Herpesviridae Infections

Virus Diseases

DNA Virus Infections

Polyomavirus Infections

Tumor Virus Infections

Carcinoma, Neuroendocrine

Adenocarcinoma

Neoplasms, Fibrous Tissue

Neoplasms, Connective Tissue

Systemic Scleroderma

Soft Tissue Sarcoma

Kaposi Sarcoma

Merkel Cell Carcinoma

Neuroendocrine Tumor

Neuroepithelioma

Optical Biopsy imaging

John S Nelson, M.D,Ph.D

This study is to compare the ability of optical biopsy. Research can use light enters the skin, collected, analyzed by the computer, and a picture created for the pathologist to conventional histologic examination compare with the pathologist looking at the piece of tissue through a microscope makes the diagnosis.

The Optical measurements provide quantitative optical property values that reflect changes in tissue perfusion, oxygen consumption, and cell/matrix development. Each measurement requires less than 5 minutes to execute. The measurements will be taken before and after skin treatment.This non-invasive, non-contact technique has great potential as a means to diagnose different skin problems without the need to obtain a piece of tissue from the skin.

Optical Biopsy of Human Skin in Conjunction With Laser Treatment

J.S.Nelson, MD,PhD,Professor of Surgery and Biomedical Engineering

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Optical Clearing of the Skin in Conjunction With Laser Treatments	NCT00580736	Port Wine Stain Nevus of Ota Tattoos Scars Acne Hypertrichosis Sebaceous Gland...	Optical Clearin...	18 Years -	University of California, Irvine
Optical Clearing of the Skin in Conjunction With Laser Treatments	NCT00580736	Port Wine Stain Nevus of Ota Tattoos Scars Acne Hypertrichosis Sebaceous Gland...	Optical Clearin...	18 Years -	University of California, Irvine
Optical Biopsy of Human Skin in Conjunction With Laser Treatment	NCT00540566	Malignant Melan... Merkel Cell Car... Basal Cell Carc... Squamous Cell C... Atypical Nevi Congenital Nevi Seborrheic Kera... Paget's Disease Dermatofibroma Kaposi's Sarcom... Port Wine Stain Hemangioma Tattoos Scleroderma Burns	Optical Biopsy ...	18 Years - 75 Years	University of California, Irvine

Spots Global Cancer Trial Database for tattoos

Every month we try and update this database with for tattoos cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for tattoos

Every month we try and update this database with for tattoos cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for tattoos cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.