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Sarcoma, Synovial

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Neoplasms by Histologic Type

Neoplasms, Connective Tissue

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Lung Diseases

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Soft Tissue Sarcoma

Synovial Sarcoma

This is a single institution study involving patients with synovial sarcoma who have completed all standard therapy (e.g. surgery +/- radiation to the primary site) +/- any adjuvant chemotherapy. The sequence and types of therapy offered prior to WLI will likely vary based on primary tumor site, tumor resectability, extent of metastatic disease, performance status, and comorbidity. Each patient's therapy will be determined by the disease management team irrespective of participation on this protocol.

External beam radiation therapy will be administered on an outpatient basis, once daily (except weekends and holidays) for approximately two weeks. Patients will undergo a simulation prior to initiation of radiation. Once an IMRT plan is generated which meets all dose constraints specified patients will be treated with 6MV photons for 10 treatments.

Whole Lung IMRT

Suzanne Wolden, MD

The purpose of this study is to find out what effects, good and/or bad, radiation has on the lungs has on the patient and on synovial sarcoma which has spread to the lungs. The standard treatment for synovial sarcoma which has spread to the lungs is chemotherapy with or without surgery to remove the tumors in the lungs. However, tumors often come back in the lungs after chemotherapy and/or surgery. Since synovial sarcoma is known to be sensitive to radiation, this study is looking at whether radiation therapy which is targeted to the entire lung can further reduce the chances of the cancer returning. This type of radiation is commonly used in other types of sarcoma to treat the cancer once it has spread to the lungs and it may be very useful in synovial sarcoma as well.

In this study, a special type of radiation will be used, called Intensity Modulated Radiation Therapy (IMRT). With IMRT the radiation beams are more customized to focus more radiation on the tumor cells while delivering less radiation to areas like the heart. The goal of this study is also to measure pulmonary toxicity and see if IMRT is feasible and has less toxicity.

Whole Lung IMRT in Children and Adults With Synovial Sarcoma and Lung Metastases

The CTCAE version 4.0 scale will be used. The radiation oncologist will score toxicity at each visit.

A CT scan of the chest will be obtained. This study will use a modified Response Evaluation Criteria in Solid Tumor (RECIST) for assessment of tumor response. Pulmonary failure-free survival will be defined as survival with no progressive disease in the lungs.

Overall survival rates will be estimated by the Kaplan-Meier method.

Memorial Sloan Kettering Cancer Center

This is a single institution study involving patients with synovial sarcoma who have completed all standard therapy (e.g. surgery +/- radiation to the primary site) +/- any adjuvant chemotherapy. The sequence and types of therapy offered prior to WLI will likely vary based on primary tumor site, tumor resectability, extent of metastatic disease, performance status, and comorbidity. Each patient's therapy will be determined by the disease management team irrespective of participation on this protocol.

Whole Lung IMRT: External beam radiation therapy will be administered on an outpatient basis, once daily (except weekends and holidays) for approximately two weeks. Patients will undergo a simulation prior to initiation of radiation. Once an IMRT plan is generated which meets all dose constraints specified patients will be treated with 6MV photons for 10 treatments.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Whole Lung IMRT in Children and Adults With Synovial Sarcoma and Lung Metastases	NCT02181829	Synovial Sarcom... Single or Multi...	Whole Lung IMRT	1 Year -	Memorial Sloan Kettering Cancer Center
Whole Lung IMRT in Children and Adults With Synovial Sarcoma and Lung Metastases	NCT02181829	Synovial Sarcom... Single or Multi...	Whole Lung IMRT	1 Year -	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for single or multiple lung metastases