Neoplasms

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Gland and Hormone Related Diseases

Symptoms and General Pathology

Rare Diseases

Carcinoma

Ovarian Neoplasms

Carcinoma, Ovarian Epithelial

Disease Progression

Cystadenocarcinoma, Serous

Chromosomal Instability

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Endocrine Gland Neoplasms

Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Genital Neoplasms, Female

Urogenital Neoplasms

Endocrine System Diseases

Gonadal Disorders

Chromosome Aberrations

Genomic Instability

Ovarian Cancer

Ovarian Epithelial Cancer

The CIN in peripheral cell-free DNA was observed before initial treatment, after primary debulking or staging surgeries, before recurrence and during the process of recurrence treatment.

Testing for chromosomal instability (CIN)

Lei Li, M.D.

Lei Li, MD

Chromosomal instability (CIN) refers to the ongoing genomic change, which involves the amplification or deletion of chromosome copy number or structure. The changes rang from point mutation to small-scale genomic change and even the change of whole chromosome number. It has been reported that the characteristics of genomic rearrangement can be used as a marker of clinical outcome of high-grade serous ovarian cancer, and specific genomic rearrangement are related to the poor prognosis. In noninvasive gene detection with low coverage, patients diagnosed with ovarian cancer have deteriorating progression-free and overall survivals regardless of the tumor stage when somatic copy number distortion (sCNA) exceeds the threshold in plasma. The detection rate of sCNA increased along with the tumor stage. We enrolled those as our target patients, who are diagnosed with high-grade serous ovarian cancer and willing to take part in. The CIN in peripheral cell-free DNA was observed before initial treatment, after primary debulking or staging surgeries, before recurrence and during the process of recurrence treatment. Our aim is to explore the application of CIN in peripheral tumor DNA in the detection of minimal residual lesions (MRD) after primary treatment and recurrence monitoring.

The chromosomal instability in peripheral cell-free DNA was observed before initial treatment, after primary debulking or staging surgeries, before recurrence and during the process of recurrence treatment.

Chromosomal Instability in Ovarian Cancer

The Role of Chromosomal Instability in Monitoring the Course of Ovarian High-grade Serous Carcinoma

Incidence of chromosomal instability tested in peripheral cell-free DNA

Progression-free survival in patients accepting CIN testing

Overall survival in patients accepting CIN testing

Lei Li

Professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Chromosomal Instability in Ovarian Cancer	NCT05310357	Epithelial Ovar... High-grade Sero... Chromosomal Ins... Somatic Copy Nu... Survival Outcom... Minimal Residua... Progression-fre... Overall Surviva...	Testing for chr...	18 Years -	Peking Union Medical College Hospital
Chromosomal Instability in Ovarian Cancer	NCT05310357	Epithelial Ovar... High-grade Sero... Chromosomal Ins... Somatic Copy Nu... Survival Outcom... Minimal Residua... Progression-fre... Overall Surviva...	Testing for chr...	18 Years -	Peking Union Medical College Hospital

Spots Global Cancer Trial Database for somatic copy number distortion