Symptoms and General Pathology

All Conditions

Neoplasms

Ear, Nose, and Throat Diseases

Nervous System Diseases

Rare Diseases

Motion Sickness

Space Motion Sickness

Neurilemmoma

Vestibular Diseases

Neuroma, Acoustic

Neuroma

Neuroendocrine Tumors

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Nerve Sheath Neoplasms

Neoplasms, Nerve Tissue

Nervous System Neoplasms

Peripheral Nervous System Neoplasms

Vestibulocochlear Nerve Diseases

Retrocochlear Diseases

Ear Diseases

Otorhinolaryngologic Diseases

Otorhinolaryngologic Neoplasms

Cranial Nerve Diseases

Labyrinth Diseases

Labyrinthitis

Schwannoma

Acoustic Neuroma

Neuroendocrine Tumor

Neuroepithelioma

Subjects that have had their eighth cranial nerve resected will receive traditional vestibular rehabilitation exercises at Johns Hopkins University (JHU) site.

Subjects that have had their eighth cranial nerve resected will receive the automated vestibular rehabilitation method

Healthy control subjects that meet similar similar physical characteristics of astronauts will receive the automated vestibular rehabilitation method post motion sickness.

Typically, the suggestion for treating motion sickness once it has started is to avoid motion. Therefore, healthy control subjects that meet similar similar physical characteristics of astronauts will not receive any post motion sickness treatment.

Exercises that teaches subjects to move their heads while viewing still or moving targets.

Traditional Therapy

The SWAN device uses video-oculography to monitor head motion while guiding participants to move their head in yaw, pitch, roll planes for 15 minutes. Feedback is provided regarding frequency and plane of head rotation

SWAN

Michael Schubert, PhD

Matthew Stewart, MD PhD

Michael C Schubert, PhD

Colin R Grove, PhD

Rich Folga

Darcy Gallimore

Richard Folga

The investigators have developed a self-administered rehabilitation tool that incrementally guides the user to increase head motion to mitigate motion sickness and enhance postural recovery following centrifugation or unilateral vestibular nerve deafferentation surgery.

The rehabilitation device guides users to perform sinusoidal head rotations, matched to a metronome, about the yaw, pitch, and roll axes (60 sec epochs, 5 minutes per axis, 15 min total). The assessment for each axis consists of the number of completed epochs with each epoch requiring head rotations of a different amplitude. Subjects are instructed to begin with an 'easy' amplitude (i.e. small) and increase or decrease amplitude depending on the subject's perception of motion sickness - which is input from 0 (absent motion sick) to 11 (vomit) using a handheld controller. Video-oculography captures eye and head velocity as well as tracks the number of blinks and saccades, metrics that can indicate worsening nausea.

At each site, one group will receive the control and the second group will receive the experimental treatment (novel rehab device).

StableEyes With Active Neurofeedback

StableEyes With Active Neurophysiological Feedback

Currently, we have no plan to share data with other researchers

Subjective rating of motion sickness intensity from 0 to 10. Zero denotes absent motion sickness while 10 denote vomiting.

Ratio of eye velocity to head velocity that varies from 0 to 1.2. Normal scores are greater than 0.8.

Increase blinking is correlated with worse motion sickness.

Heart rate in beats per minute will be measured using a monitor worn over the forearm.

Time measured in seconds for a subject to stand up, step over an obstacle then walk 3M before turning around and sitting down.

Time in seconds to stand on foam with eyes open. Inability to stand for less than 20 seconds is associated with 3x greater risk for falling.

Time in seconds to stand on foam with eyes closed. Inability to stand for less than 20 seconds is associated with 3x greater risk for falling.

Time to seconds to stand on foam with eyes open while moving head up and down. Inability to stand for less than 20 seconds is associated with 3x greater risk for falling.

Time in seconds to stand on foam with eyes closed while moving head up and down. Inability to stand for less than 20 seconds is associated with 3x greater risk for falling.

Velocity to walk 6m within a 10m marked distance, measured in meters/second. Normative data exists based on decade of age.

Distance walked in 2 minutes, measure in meters.

Vertical alignment nulling and torsional alignment nulling ask subjects to adjust lines to there perceived horizontal. Measured in degrees.

Subjects adjust a virtual line to their perceived vertical, measured in degrees.

Subjects wear an activity monitor on their wrist Data includes daily distance walked .

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
StableEyes With Active Neurofeedback	NCT05622344	Vestibular Diso... Vestibular Schw... Space Motion Si... Motion Sickness	Traditional The... SWAN	21 Years - 70 Years	Johns Hopkins University
StableEyes With Active Neurofeedback	NCT05622344	Vestibular Diso... Vestibular Schw... Space Motion Si... Motion Sickness	Traditional The... SWAN	21 Years - 70 Years	Johns Hopkins University

Spots Global Cancer Trial Database for space motion sickness