Blood and Lymph Conditions

All Conditions

Symptoms and General Pathology

Musculoskeletal Diseases

Neoplasms

Skin and Connective Tissue Diseases

Nervous System Diseases

Lymphedema

Pain

Shoulder Pain

Breast Neoplasms

Breast Cancer Lymphedema

Lymphatic Diseases

Arthralgia

Joint Diseases

Neurologic Manifestations

Postoperative Complications

the patients will receive Ga-As Laser and traditional therapy three times a week for three months

the patients will receive Microcurrent Electrical Stimulation and traditional therapy three times a week for three months

the patients will receive traditional therapy three times a week for three months

Patient sits on a chair with back support and the two GA-AS laser ( 5 milli Watts \& 904 nm) probe will be applied one on the shoulder tip for 5 minutes and the other application another 5 minutes will be on the center of deltoid muscle. The main power of the laser switch will be turned on. The duration of the treatment will be 10 minutes.

Ga-As Laser

The patient sits on a chair with back support and the two electrodes from Microcurrent 850 unit device will be applied one on the shoulder tip and the other electrode on the center of the deltoid muscle. A wet cloth was placed between the electrode and the patient's skin. An adhesive tape was used to hold the electrode over the treated areas. The main power switch will be turned on. The treatment duration will be for 10 minutes.

Microcurrent Electrical Stimulation

the patients will receive traditional physical therapy in the form of manual lymphatic drainage , compression bandage, exercise to increase lymphatic drainage, skin care. and ROM exercises to improve shoulder mobility

traditional therapy

the aim of this study is to investigate the effect of GA-AS laser versus microcurrent on post-mastectomy shoulder pain and lymphedema.

Breast cancer is extremely rare before the age of 25. It reaches a high incidence in the decade from 40 to 50 and continuous to increase in the frequency into old age. Mastectomy is the traditional approach to remove the entire breast once the diagnosis was confirmed. The most common cancers are lung cancer in men and breast cancer in women, however despite the large numbers of people affected by cancer there is very little literature on the role of physiotherapists in cancer care. After mastectomy and the accompanying excision or radiation of adjacent axillary lymph nodes a patient is at risk of developing upper extremity lymphedema, shoulder pain and loss of shoulder motion.low-level laser light waves penetrate deeply into the skin, they optimize the immune responses of our blood. This has both anti-inflammatory and immunosuppressive effects. It is a scientific fact that light transmitted to the blood in this way has positive effects throughout the whole body, supplying vital oxygen and energy to every cell .Electrical stimulation is based on the fact that human body has an endogenous bioelectric system that enhances healing of bone fracture, soft tissue lesions and decreasing post-operative pain. The external current may serve to mimic the failed natural bioelectric currents, so that post-operative pain can be inhibited. It was reported that microcurrent electrical neuromuscular stimulation (MENS) is better in enhancing cellular physiology processes than other current of higher amplitude, microcurrent is effective in the management of open wounds, inflammation and pain. sixty patients will be randomly allocated to three groups; first one will receive laser+ traditional therapy, second one will receive microcurrent + traditional therapy and third one will receive traditional therapy three times a week for three months.

Post-Mastectomy Shoulder Pain And Lymphedema Responses To Ga-As Laser Versus Microcurrent Electrical Stimulation

pain intensity will be measured by visual analogue scale

lymphedema volume will be measured by measuring the circumference of each segment of the limb between two consecutive circumferences as a truncated zone. The volume of the segment was calculated as V=h(C12 +C1C2+C22 )/12π, where V is the volume of the segment, C1 and C2 are the circumferences at the ends of the segment, and h is the distance between them (segment length)

Cairo University

principle investigator

Ear, Nose, and Throat Diseases

Rare Diseases

Motion Sickness

Space Motion Sickness

Neurilemmoma

Vestibular Diseases

Neuroma, Acoustic

Neuroma

Neuroendocrine Tumors

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Nerve Sheath Neoplasms

Neoplasms, Nerve Tissue

Nervous System Neoplasms

Peripheral Nervous System Neoplasms

Vestibulocochlear Nerve Diseases

Retrocochlear Diseases

Ear Diseases

Otorhinolaryngologic Diseases

Otorhinolaryngologic Neoplasms

Cranial Nerve Diseases

Labyrinth Diseases

Labyrinthitis

Schwannoma

Acoustic Neuroma

Neuroendocrine Tumor

Neuroepithelioma

Subjects that have had their eighth cranial nerve resected will receive traditional vestibular rehabilitation exercises at Johns Hopkins University (JHU) site.

Subjects that have had their eighth cranial nerve resected will receive the automated vestibular rehabilitation method

Healthy control subjects that meet similar similar physical characteristics of astronauts will receive the automated vestibular rehabilitation method post motion sickness.

Typically, the suggestion for treating motion sickness once it has started is to avoid motion. Therefore, healthy control subjects that meet similar similar physical characteristics of astronauts will not receive any post motion sickness treatment.

Exercises that teaches subjects to move their heads while viewing still or moving targets.

Traditional Therapy

The SWAN device uses video-oculography to monitor head motion while guiding participants to move their head in yaw, pitch, roll planes for 15 minutes. Feedback is provided regarding frequency and plane of head rotation

SWAN

Michael Schubert, PhD

Matthew Stewart, MD PhD

Michael C Schubert, PhD

Colin R Grove, PhD

Rich Folga

Darcy Gallimore

Richard Folga

The investigators have developed a self-administered rehabilitation tool that incrementally guides the user to increase head motion to mitigate motion sickness and enhance postural recovery following centrifugation or unilateral vestibular nerve deafferentation surgery.

The rehabilitation device guides users to perform sinusoidal head rotations, matched to a metronome, about the yaw, pitch, and roll axes (60 sec epochs, 5 minutes per axis, 15 min total). The assessment for each axis consists of the number of completed epochs with each epoch requiring head rotations of a different amplitude. Subjects are instructed to begin with an 'easy' amplitude (i.e. small) and increase or decrease amplitude depending on the subject's perception of motion sickness - which is input from 0 (absent motion sick) to 11 (vomit) using a handheld controller. Video-oculography captures eye and head velocity as well as tracks the number of blinks and saccades, metrics that can indicate worsening nausea.

At each site, one group will receive the control and the second group will receive the experimental treatment (novel rehab device).

StableEyes With Active Neurofeedback

StableEyes With Active Neurophysiological Feedback

Currently, we have no plan to share data with other researchers

Subjective rating of motion sickness intensity from 0 to 10. Zero denotes absent motion sickness while 10 denote vomiting.

Ratio of eye velocity to head velocity that varies from 0 to 1.2. Normal scores are greater than 0.8.

Increase blinking is correlated with worse motion sickness.

Heart rate in beats per minute will be measured using a monitor worn over the forearm.

Time measured in seconds for a subject to stand up, step over an obstacle then walk 3M before turning around and sitting down.

Time in seconds to stand on foam with eyes open. Inability to stand for less than 20 seconds is associated with 3x greater risk for falling.

Time in seconds to stand on foam with eyes closed. Inability to stand for less than 20 seconds is associated with 3x greater risk for falling.

Time to seconds to stand on foam with eyes open while moving head up and down. Inability to stand for less than 20 seconds is associated with 3x greater risk for falling.

Time in seconds to stand on foam with eyes closed while moving head up and down. Inability to stand for less than 20 seconds is associated with 3x greater risk for falling.

Velocity to walk 6m within a 10m marked distance, measured in meters/second. Normative data exists based on decade of age.

Distance walked in 2 minutes, measure in meters.

Vertical alignment nulling and torsional alignment nulling ask subjects to adjust lines to there perceived horizontal. Measured in degrees.

Subjects adjust a virtual line to their perceived vertical, measured in degrees.

Subjects wear an activity monitor on their wrist Data includes daily distance walked .

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Post-Mastectomy Shoulder Pain And Lymphedema Responses To Ga-As Laser Versus Microcurrent Electrical Stimulation	NCT05870241	Post Mastectomy...	Ga-As Laser Microcurrent El... traditional the...	40 Years - 55 Years	Cairo University
StableEyes With Active Neurofeedback	NCT05622344	Vestibular Diso... Vestibular Schw... Space Motion Si... Motion Sickness	Traditional The... SWAN	21 Years - 70 Years	Johns Hopkins University
StableEyes With Active Neurofeedback	NCT05622344	Vestibular Diso... Vestibular Schw... Space Motion Si... Motion Sickness	Traditional The... SWAN	21 Years - 70 Years	Johns Hopkins University
Post-Mastectomy Shoulder Pain And Lymphedema Responses To Ga-As Laser Versus Microcurrent Electrical Stimulation	NCT05870241	Post Mastectomy...	Ga-As Laser Microcurrent El... traditional the...	40 Years - 55 Years	Cairo University

Spots Global Cancer Trial Database for traditional therapy