Neoplasms

All Conditions

Symptoms and General Pathology

Infections

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Mouth and Tooth Diseases

Ear, Nose, and Throat Diseases

Carcinoma

Carcinoma, Squamous Cell

Neoplasm Metastasis

Communicable Diseases

Virus Diseases

Papillomavirus Infections

Papilloma

Oropharyngeal Neoplasms

Lymphatic Metastasis

Head and Neck Neoplasms

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Neoplasms, Squamous Cell

Neoplastic Processes

Sexually Transmitted Diseases

Sexually Transmitted Diseases, Viral

DNA Virus Infections

Tumor Virus Infections

Genital Diseases

Urogenital Diseases

Disease Attributes

The prospective observational study involves the collection of tissue, blood and saliva samples from OPSCC and occult T patients for detection of HPV-DNA/RNA, miRNA and mutation profile from DNA with centralized analysis of samples at IRCCS Regina Elena National Cancer Institute.

Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx

Raul Pellini, Doctor

Raul Pellini, MD

Based on the evidence summarized in the introduction, the clinician hypothesize that the detection of the presence and expression of HPV-DNA, certain miRNAs, and a certain mutational profile in the tissues and biological fluids of these patients, may have important prognostic and diagnostic value not only in HPV-related OPSCCs but also in HPV+ occult T. Accordingly, this study aims to aim to better characterize their potential as biomarkers and to detect the possibility of their their use to implement the sensitivity and specificity of radiological methodologies (PET-CT and MRI), already in use in clinical practice, for monitoring disease progression in this specific subgroup. Finally, by using the collected material to generate organoids and Patient Derived Xenograft (PDX), the study also aims to identify possible new molecular drugs, which could solve the problem of resistance to radiochemotherapy.

Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus

Investigating the kinetics of HPV-DNA and miRNAs in patients with oropharyngeal and occult T tumors with laterocervical metastasis. Conducting this study will allow us to collect the information needed to be able to generate hypotheses and design a subsequent larger study.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus	NCT05918510	Squamous Cell C... Carcinomas of U... High-risk Human... Liquid Biopsy Lymph Node Meta... Occult Tumor of...	Study of Viral ...	18 Years -	Regina Elena Cancer Institute
Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus	NCT05918510	Squamous Cell C... Carcinomas of U... High-risk Human... Liquid Biopsy Lymph Node Meta... Occult Tumor of...	Study of Viral ...	18 Years -	Regina Elena Cancer Institute

Spots Global Cancer Trial Database for study of viral biomarkers and micrornas in tumors orofarynx