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The enrolled patients will be accepted submucosal injection of saline,then ultrasonography will performed(EUS+SIS group).So,stages of EUS in these early esophageal cancer will be recorded and compared with the pathological stages afer endoscopic mucosal resection(EMR) or endoscopic submucosal dissection(ESD) or esophagectomy.

The enrolled patients will accept ordinary ultrasonography .So,stages of EUS in these early esophageal cancer will be recorded and compared with the pathological stages afer endoscopic mucosal resection(EMR) , endoscopic submucosal dissection(ESD) or esophagectomy.

The patients will accepted submucosal injection of 5ml saline followed by ordinary endosonography(EUS) before surgery or endoscopic dissection.

submucosal injection needle ; EUS

These patients will be accepted ordinary EUS followed by surgery or endoscopic dissection.

ordinary endosonography(EUS)

Jian-jun Li, M.D. Ph.D.

Jian-jun Li, M.D. Ph.D

Jian-jun Li, M.D.

Preoperative accurately staging T1a or T1b in early esophageal cancer is vital for the choices of treatment. At present, the main diagnostic method for early esophageal cancer is endoscopic ultrasound (EUS). However, the accuracy of EUS alone is poor. Thus, it is necessary to improve endoscopic ultrasound examination methods. This project is concerning on the efficacy of EUS combining with submucosal injection of saline for staging T1a and T1b-esophageal cancer. Patients and methods: 80 cases of pathological confirmed early esophageal cancer were randomly divided into two groups: endoscopic ultrasonography group (EUS group) and EUS combining with submucosal injecting saline group (EUS+SIS group). All the cases will be performance by endoscopic or surgical resection; postoperative pathologic diagnosis will be obtained involving echo, depth, margin and other features. The EUS results of two groups of patients will be compared with pathologic results. From comparison, the efficacy and accuracy of EUS+SIS for staging T1a and T1b in esophageal cancer patients will be validated. Through this study, the investigators may develop a routine diagnostic and accurately staging method for early esophageal cancer patients.

Someone whom may concern our IPD are available to the PI, Jian-jun Li M.D. or at lijj@sysucc.org.cn

Endoscopic Ultrasound Plus Submucosal Injection for Early Esophageal Cancer

Efficacy Study of Endoscopic Ultrasound Combining With Submucosal Saline Injection for Pretreatment Staging of T1a and T1b in Patients With Early Esophageal Cancer

The stages judged from submucosal injection plus EUS or ordinary EUS will be compared with the pathological results after endoscopic or surgical resection.So the sensitivity,specificity,positive predictive value,negative predictive value and diagnostic accuracy of either submucosal injection plus EUS or ordinary EUS for early esophageal cancer will be measured respectivly.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Endoscopic Ultrasound Plus Submucosal Injection for Early Esophageal Cancer	NCT01555801	Esophageal Canc...	submucosal inje... ordinary endoso...	18 Years - 65 Years	Sun Yat-sen University
Endoscopic Ultrasound Plus Submucosal Injection for Early Esophageal Cancer	NCT01555801	Esophageal Canc...	submucosal inje... ordinary endoso...	18 Years - 65 Years	Sun Yat-sen University
Endoscopic Ultrasound Plus Submucosal Injection for Early Esophageal Cancer	NCT01555801	Esophageal Canc...	submucosal inje... ordinary endoso...	18 Years - 65 Years	Sun Yat-sen University
Endoscopic Ultrasound Plus Submucosal Injection for Early Esophageal Cancer	NCT01555801	Esophageal Canc...	submucosal inje... ordinary endoso...	18 Years - 65 Years	Sun Yat-sen University

Spots Global Cancer Trial Database for submucosal injection needle ; eus