Symptoms and General Pathology

All Conditions

Neoplasms

Digestive System Diseases

Behaviors and Mental Disorders

Disease Progression

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Quality of Life

Drug: Brucea javanica oil emulsion injection Brucea javanica oil emulsion injection: intravenous drip, 30ml each time (add 250ml sterile physiological saline),once a day, 14 consecutive days as a cycle, at least 2 cycles completed. The best supportive treatment:According to the NCCN Best Palliative Treatment Guidelines (2022. V1), provide the best supportive treatment

Brucea javanica oil emulsion injection

The best supportive treatment:According to the NCCN Best Palliative Treatment Guidelines (2022. V1), provide the best supportive treatment

The best supportive treatment

Ying Zhang, proffessor

Hanrui Chen, professor

Peng Shu, professor

Huijie Li, professor

Yabin Gong, professor

The purpose of the study is to evaluate the safety and effectiveness of Brucea javanica oil emulsion injection in patients with advanced colorectal cancer who failed to undergo multi-line treatment

this study included a prospective, multicenter, randomized controlled clinical trial.

About 60 patients will be recruited in the randomized clinical trial. Participants will be randomly divided into experimental group (n=30) and control group (n=30). The patients in the experimental group will receive Brucea javanica oil emulsion injection combined with the best supportive treatment, based on the NCCN best palliative treatment guidelines (2022. V1). The patients in the control group received the best supportive treatment based on the NCCN's best palliative treatment guidelines (2022. V1). The primary end point was PFS (progression-free survival). The research protocol was approved by the relevant ethics committee. The research was conducted in accordance with the Helsinki Declaration and good clinical practice guidelines. The patient has written informed consent to participate in the trial.

Clinical Study on the Effect of Brucea Javanica Oil Emulsion Injection on the Survival of Patients With Advanced Colorectal Cancer Who Failed to Receive Multi-line Treatment

The results of the study will be issued to publications through scientific journals and conference reports.

equlity of life assessed by the MDASI \[followed by its scale information in the Description\]")

equlity of life assessed by the EORTC QLQ-C30 \[followed by its scale information in the Description\]")

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Clinical Study on the Effect of Brucea Javanica Oil Emulsion Injection on the Survival of Patients With Advanced Colorectal Cancer Who Failed to Receive Multi-line Treatment	NCT05897749	Colorectal Canc... Chinese Herbal ... Progression-fre... Quality of Life	Brucea javanica... The best suppor...	18 Years - 75 Years	Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Clinical Study on the Effect of Brucea Javanica Oil Emulsion Injection on the Survival of Patients With Advanced Colorectal Cancer Who Failed to Receive Multi-line Treatment	NCT05897749	Colorectal Canc... Chinese Herbal ... Progression-fre... Quality of Life	Brucea javanica... The best suppor...	18 Years - 75 Years	Guang'anmen Hospital of China Academy of Chinese Medical Sciences

Spots Global Cancer Trial Database for the best supportive treatment